Results 21 to 30 of about 1,113,115 (292)

Modeling Evolution of Intratumor Phenotypic Heterogeneity in Metastasis and Cancer Drug Resistance [PDF]

, 2023
Most tumors are complex ecosystems that emerge and evolve under robust selective pressure from their microenvironment. Such a pressure promotes the diversification of both tumor cells and the tumor microenvironment, resulting in increased intratumoral ...
Zhang, Bin
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Phenotypic heterogeneity in cystic fibrosis [PDF]

American Journal of Medical Genetics, 1982
AbstractWe have confirmed heterogenity in CF using a different combination of primary clinical variables than those used in previous studies. Subgroupings of individuals with similar levels of sweat chloride were independent of the clustering based on level of pancreatic enzyme supplementation and degree of pulmonary involvement.
Sing, Charles F., Risser, David R., Howatt, William F., Erickson, Robert P.   +3 more
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Phenotypic heterogeneity in severe hemophilia [PDF]

Journal of Thrombosis and Haemostasis, 2007
Large heterogeneity in bleeding pattern and arthropathy is observed among patients with severe hemophilia. Studies have reported a large variability in bleeding pattern among patients with severe hemophilia. Of special interest are some 10% of the patients with severe hemophilia who only rarely bleed and don't need prophylactic therapy.
H M, van den Berg, P H G, De Groot, K, Fischer   +2 more
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Hypertrabeculation; a phenotype with Heterogeneous etiology

Progress in Cardiovascular Diseases, 2021
Left ventricular hypertrabeculation (LVHT) is a phenotype with multiple etiologies and variable clinical presentation and significance. It is characterized by a 2-layer myocardium with an enlarged trabecular layer and a thinner compacted layer. The prevalence has been increasing due to advances in cardiac imaging.
Fatemeh, Adabifirouzjaei, Sachiyo, Igata, Anthony Nicholas, DeMaria   +2 more
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Genetic heterogeneity of residual variance in broiler chickens [PDF]

, 2006
Aims were to estimate the extent of genetic heterogeneity in environmental variance. Data comprised 99 535 records of 35-day body weights from broiler chickens reared in a controlled environment.
Rowe Suzanne J, Avendano, Santiago, Hill, William G., White, Ian M. S., White Ian MS, Ian M.S. White, Avendaño Santiago, Hill William G, Suzanne J. Rowe, William G. Hill, Suzanne J Rowe, Ian MS White, William G Hill, Santiago Avendaño, Rowe, Suzanne J.   +14 more
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Population Heterogeneity of Lactobacillus plantarum WCFS1 Microcolonies in Response to and Recovery from Acid Stress [PDF]

, 2008
Within an isogenic microbial population in a homogenous environment, individual bacteria can still exhibit differences in phenotype. Phenotypic heterogeneity can facilitate the survival of subpopulations under stress.
Ingham, C.J., Vlieg, J.E.T.V.H., C. J. Ingham, M. Beerthuyzen, J. van Hylckama Vlieg, Beerthuyzen, M.   +5 more
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Prediction of breeding values and selection responses with genetic heterogeneity of environmental variance [PDF]

, 2007
There is empirical evidence that genotypes differ not only in mean, but also in environmental variance of the traits they affect. Genetic heterogeneity of environmental variance may indicate genetic differences in environmental sensitivity.
Mulder, H. A., H. A. Mulder, W. G. Hill, Mulder, H.A., Hill, W. G., Bijma, P., Hill, W.G., P. Bijma   +7 more
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Phenotypic melanoma heterogeneity is regulated through cell-matrix interaction-dependent changes in tumor microarchitecture

, 2022
Phenotypic heterogeneity of solid cancer plays a critical role in shaping treatment response. This type of heterogeneity is organized spatially with specific phenotypes, such as distinct clusters of proliferating and cell cycle-arrested cells within a ...
Tonnessen-Murray, CA, Smith, AG, Beaumont, KA, Chauhan, J, Daignault-Mill, SM, Gabrielli, B, Hill, DS, Jurek, RJ, Matigian, N, Boyle, G, Spoerri, L, Gunasingh, G, Fane, ME, Scott, E, et al., Vanwalleghem, GC   +15 more
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Phenotypic heterogeneity in bacterial populations

Acta Agriculturae Slovenica, 2007
Genetically uniform bacterial cells exhibit heterogeneity such as intrapopulation differences in metabolism as well as variation in growth rate.
Darja ŽGUR-BERTOK
doaj   +1 more source

Phenotypic flexibility and the evolution of organismal design [PDF]

, 2003
Evolutionary biologists often use phenotypic differences between species and between individuals to gain an understanding of organismal design. The focus of much recent attention has been on developmental plasticity – the environmentally induced ...
Piersma, T, Drent, Jan,, Piersma, Theunis,, Piersma, T; id_orcid, Drent, J   +4 more
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