Results 11 to 20 of about 965,054 (258)

Phase variation in Mannheimia haemolytica challenges the static genome paradigm [PDF]

Microbiology Spectrum
Mannheimia haemolytica is a key agent in bovine respiratory disease (BRD), driving antibiotic use in feedyard cattle. As a facultative anaerobe commonly found in the upper respiratory tracts of cattle, its role under anaerobic conditions in BRD has not ...
Gregory P. Harhay, Kelsey K. McClure, Kerry D. Brader, Kristen L. Kuhn, Timothy P. L. Smith, Dayna M. Harhay   +5 more
doaj   +2 more sources

Phase Variation of LPS and Capsule Is Responsible for Stochastic Biofilm Formation in Francisella tularensis [PDF]

Frontiers in Cellular and Infection Microbiology, 2022
Biofilms have been established as an important lifestyle for bacteria in nature as these structured communities often enable survivability and persistence in a multitude of environments. Francisella tularensis is a facultative intracellular Gram-negative
Kevin D. Mlynek, Christopher T. Lopez, David P. Fetterer, Janice A. Williams, Joel A. Bozue   +4 more
doaj   +2 more sources

Why vary what’s working? Phase variation and biofilm formation in Francisella tularensis [PDF]

Frontiers in Microbiology, 2022
The notoriety of high-consequence human pathogens has increased in recent years and, rightfully, research efforts have focused on understanding host-pathogen interactions.
Kevin D. Mlynek, Joel A. Bozue
doaj   +2 more sources

No Change, No Life? What We Know about Phase Variation in Staphylococcus aureus [PDF]

Microorganisms, 2021
Phase variation (PV) is a well-known phenomenon of high-frequency reversible gene-expression switching. PV arises from genetic and epigenetic mechanisms and confers a range of benefits to bacteria, constituting both an innate immune strategy to infection
Vishal Gor, Ryosuke L. Ohniwa, Kazuya Morikawa   +2 more
doaj   +2 more sources

Phase Variation During Host Colonization and Invasion by Campylobacter jejuni and Other Campylobacter Species [PDF]

Frontiers in Microbiology, 2021
Phase variation (PV) is a phenomenon common to a variety of bacterial species for niche adaption and survival in challenging environments. Among Campylobacter species, PV depends on the presence of intergenic and intragenic hypermutable G/C homopolymeric
Caroline Cayrou, Natalie A. Barratt, Julian M. Ketley, Christopher D. Bayliss   +3 more
doaj   +2 more sources

Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of Streptococcus pneumoniae [PDF]

mBio, 2021
Streptococcus pneumoniae is an opportunistic pathogen that can alter its cell surface phenotype in response to the host environment. We demonstrated that the transcriptional regulator FabT is an indirect regulator of capsular polysaccharide, an important
Jinghui Zhang, Weijie Ye, Kaifeng Wu, Shengnan Xiao, Yuqiang Zheng, Zhaoche Shu, Yibing Yin, Xuemei Zhang   +7 more
doaj   +2 more sources

Enterococcus faecalis modulates phase variation in Clostridioides difficile [PDF]

Journal of Bacteriology
To adapt and persist in the gastrointestinal tract, many enteric pathogens, including Clostridioides difficile, employ strategies such as phase variation to generate phenotypically heterogeneous populations.
Ashley S. Weiss, Jilarie A. Santos-Santiago, Orlaith Keenan, Alexander B. Smith, Montana Knight, Joseph P. Zackular, Rita Tamayo   +6 more
doaj   +2 more sources

Phase Variation ofStreptococcus pneumoniae [PDF]

Microbiology Spectrum, 2019
ABSTRACTStreptococcus pneumoniaeundergoes phase variation or spontaneous, reversible phenotypic variation in colony opacity, encapsulation, and pilus expression. The variation in colony opacity appears to occur in all strains, whereas the switches in the production of the capsule and pilus have been observed in several strains.
Jing, Li, Jing-Ren, Zhang
openaire   +3 more sources

Phage-Resistant Phase-Variant Sub-populations Mediate Herd Immunity Against Bacteriophage Invasion of Bacterial Meta-Populations

Frontiers in Microbiology, 2019
Hypermutable loci are widespread in bacteria as mechanisms for rapid generation of phenotypic diversity within a population that enables survival of fluctuating, often antagonistic, selection pressures. Localized hypermutation can mediate phase variation
Christopher J. R. Turkington, Andrew Morozov, Martha R. J. Clokie, Christopher D. Bayliss   +3 more
doaj   +1 more source

Phase variation in the genus Serratia [PDF]

Journal of Medical Microbiology, 1980
During an investigation of the serotypes of Serratia marcescens present in a cancer centre, it was found that 8.7% of 241 strains had more than one H antigen. There were 19 diphasic and two triphasic strains. Antigen H1 was a component of the phases in the approximately half of the strains with multiple phases.
V M, Young, M R, Moody, M J, Morris
openaire   +2 more sources