Phase variation and antigenic variation
, 2005 A review on the best understood mechanisms of phenotypic diversification by phase variation and antigenic variation, and their functions. Topics discussed include DNA inversion, gene conversion, phase variation by slipped-strand mispairing, phase variation by an epigenetic mechanism, influence of environmental conditions on phase variation, and phase ...
Villemur, Richard, Déziel, Éric
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Phase variation of hadronic amplitudes [PDF]
Physical Review C, 2008 The phase variation with angle of hadronic amplitudes is studied with a view to understanding the underlying physical quantities which control it and how well it can be determined in free space. We find that unitarity forces a moderately accurate determination of the phase in standard amplitude analyses but that the nucleon-nucleon analyses done to ...
Dedonder, J. P. +2 more
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Microbial Primer: Phase variation - survival and adaptability by generation of a diverse population. [PDF]
Microbiology (Reading)Phase variation is defined as the rapid and reversible switching of gene expression, and typically occurs in genes encoding surface features in small genome bacterial pathogens.
Fraser AJ, McMahon FE, Atack JM.
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Phase variation in Mannheimia haemolytica challenges the static genome paradigm [PDF]
Microbiology SpectrumMannheimia haemolytica is a key agent in bovine respiratory disease (BRD), driving antibiotic use in feedyard cattle. As a facultative anaerobe commonly found in the upper respiratory tracts of cattle, its role under anaerobic conditions in BRD has not ...
Gregory P. Harhay +5 more
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Phase Variation of LPS and Capsule Is Responsible for Stochastic Biofilm Formation in Francisella tularensis [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Biofilms have been established as an important lifestyle for bacteria in nature as these structured communities often enable survivability and persistence in a multitude of environments. Francisella tularensis is a facultative intracellular Gram-negative
Kevin D. Mlynek +4 more
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Why vary what’s working? Phase variation and biofilm formation in Francisella tularensis [PDF]
Frontiers in Microbiology, 2022 The notoriety of high-consequence human pathogens has increased in recent years and, rightfully, research efforts have focused on understanding host-pathogen interactions.
Kevin D. Mlynek, Joel A. Bozue
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No Change, No Life? What We Know about Phase Variation in Staphylococcus aureus [PDF]
Microorganisms, 2021 Phase variation (PV) is a well-known phenomenon of high-frequency reversible gene-expression switching. PV arises from genetic and epigenetic mechanisms and confers a range of benefits to bacteria, constituting both an innate immune strategy to infection
Vishal Gor +2 more
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Phase Variation During Host Colonization and Invasion by Campylobacter jejuni and Other Campylobacter Species [PDF]
Frontiers in Microbiology, 2021 Phase variation (PV) is a phenomenon common to a variety of bacterial species for niche adaption and survival in challenging environments. Among Campylobacter species, PV depends on the presence of intergenic and intragenic hypermutable G/C homopolymeric
Caroline Cayrou +3 more
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A single nucleotide polymorphism collapses phase variation and drives short-sighted evolution of O-antigen in Salmonella [PDF]
Gut MicrobesThe O-antigen of Salmonella is a key virulence determinant and serotype-defining structure, yet the regulatory mechanisms underlying its dynamic modification and evolutionary trade-offs remain incompletely understood.
Yiluo Cheng +13 more
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Inactivation of Transcriptional Regulator FabT Influences Colony Phase Variation of
mBio, 2021 Streptococcus pneumoniae is an opportunistic pathogen that can alter its cell surface phenotype in response to the host environment. We demonstrated that the transcriptional regulator FabT is an indirect regulator of capsular polysaccharide, an important
Jinghui Zhang +7 more
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