Abstract In complex food systems, bacteria live in heterogeneous microstructures, and the population displays phenotypic heterogeneities at the single‐cell level. This review provides an overview of spatiotemporal drivers of phenotypic heterogeneity of bacterial pathogens in food matrices at three levels.
Cédric Saint Martin +11 more
wiley +1 more source
Data_Sheet_1_Phase-variable Type I methyltransferase M.NgoAV from Neisseria gonorrhoeae FA1090 regulates phasevarion expression and gonococcal phenotype.PDF [PDF]
The restriction-modification (RM) systems are compared to a primitive, innate, prokaryotic immune system, controlling the invasion by foreign DNA, composed of methyltransferase (MTase) and restriction endonuclease.
Natalia Matczynska (13901700) +5 more
core +1 more source
Image_1_Phase-variable Type I methyltransferase M.NgoAV from Neisseria gonorrhoeae FA1090 regulates phasevarion expression and gonococcal phenotype.TIF [PDF]
The restriction-modification (RM) systems are compared to a primitive, innate, prokaryotic immune system, controlling the invasion by foreign DNA, composed of methyltransferase (MTase) and restriction endonuclease.
Natalia Matczynska (13901700) +5 more
core +1 more source
Selective and non‐selective bottlenecks as drivers of the evolution of hypermutable bacterial loci
Bottlenecks produce dramatic reductions in the genetic diversity of bacterial populations. Bottleneck events can be selective or non‐selective and occur frequently, particularly during transmission between hosts. Multiple mutational strategies have evolved in bacteria that can regenerate genetic diversity within surviving populations following a major ...
Megan De Ste Croix +5 more
wiley +1 more source
Phase-variable restriction/modification systems are required for Helicobacter pylori colonization. [PDF]
BackgroundOne mechanism utilized by bacterial pathogens for host adaptation and immune evasion is the generation of phenotypic diversity by the phasevarion that results from the differential expression of a suite of genes regulated by the activity of a ...
Gauntlett JC +4 more
europepmc +2 more sources
The comparative analysis of the genome sequences of five Y. ruckeri strains (150, CSF007‐82, ATCC29473, Big Creek 74, and SC09) isolated from different hosts and classified into different serotypes revealed important genetic differences between the genomes analyzed. These could provide insights into the understanding of the virulence and niche adaptive
Desirée Cascales +3 more
wiley +1 more source
In the last decades, tremendous advancement in dissecting the mechanisms of pathogenicity of Neisseria meningitidis at a molecular level has been achieved, exploiting converging approaches of different disciplines, ranging from pathology to microbiology, immunology, and omics sciences (such as genomics and proteomics).
R. Gasparini +8 more
wiley +1 more source
Themes and Variations: Regulation of RpoN‐Dependent Flagellar Genes across Diverse Bacterial Species
Flagellar biogenesis in bacteria is a complex process in which the transcription of dozens of structural and regulatory genes is coordinated with the assembly of the flagellum. Although the overall process of flagellar biogenesis is conserved among bacteria, the mechanisms used to regulate flagellar gene expression vary greatly among different ...
Jennifer Tsang +4 more
wiley +1 more source
DNA methylation assessed by SMRT sequencing is linked to mutations in Neisseria meningitidis isolates [PDF]
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To present, proposed virulence genotypes are also detected in isolates from asymptomatic carriers, indicating more complex mechanisms underlying variable ...
Gerd Pluschke +26 more
core +1 more source
Phase-variable bacterial loci: how bacteria gamble to maximise fitness in changing environments.
Phase-variation of genes is defined as the rapid and reversible switching of expression - either ON-OFF switching or the expression of multiple allelic variants. Switching of expression can be achieved by a number of different mechanisms.
Zachary N. Phillips +3 more
semanticscholar +1 more source

