Results 1 to 10 of about 4,073 (199)

Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi [PDF]

Respiratory Research, 2017
Background Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophages.
Dave Singh, Hannah Metcalfe, Simon Lea   +2 more
exaly   +11 more sources

Dual RNASeq Reveals NTHi-Macrophage Transcriptomic Changes During Intracellular Persistence [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Nontypeable Haemophilus influenzae (NTHi) is a pathobiont which chronically colonises the airway of individuals with chronic respiratory disease and is associated with poor clinical outcomes.
Ashley Heinson, Myron Christodoulides, T M A Wilkinson   +2 more
exaly   +7 more sources

Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD [PDF]

PLoS ONE, 2016
Non-typeable Haemophilus influenzae (NTHi) is a key pathogen in COPD, being associated with airway inflammation and risk of exacerbation. Why some patients are susceptible to colonisation is not understood. We hypothesised that this susceptibility may be
Lindsay Welch, Kristoffer Ostridge, Stuart Clarke   +2 more
exaly   +5 more sources

Haemophilus haemolyticus Interaction with Host Cells Is Different to Nontypeable Haemophilus influenzae and Prevents NTHi Association with Epithelial Cells [PDF]

Frontiers in Cellular and Infection Microbiology, 2016
Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that resides in the upper respiratory tract and contributes to a significant burden of respiratory related diseases in children and adults.
Lea-Ann Kirkham, Peter Richmond, Ruth Thornton   +2 more
exaly   +5 more sources

RSV-NTHi Co-Infection Skews Host Immunity by Suppressing Type I IFN Responses and Enhancing Pro-Inflammatory Responses [PDF]

Pathogens
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children, yet determinants of disease severity in otherwise healthy infants remain poorly understood.
Zhinian Zhou, Justin W. Brennan, Ann Lindley Gill, Christopher S. Anderson, Brian M. Ward, Gloria Pryhuber, Thomas J. Mariani, Steven R. Gill, Yan Sun   +8 more
doaj   +2 more sources

Characterization of a conserved outer-membrane protein in non-typeable Haemophilus influenzae with an unidentified impact on phenotype [PDF]

Microbiology Spectrum
Non-typeable Haemophilus influenzae (NTHi) is an opportunistic bacterial pathogen of the human airway and is a cause of significant morbidity and mortality worldwide.
Ashley J. Fraser, Oren Cooper, Brian M. Forde, Timothy F. Murphy, Michael P. Jennings, John M. Atack   +5 more
doaj   +2 more sources

Host-pathogen interaction profiling of nontypeable Haemophilus influenzae and Moraxella catarrhalis coinfection of bronchial epithelial cells [PDF]

mSphere
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung disease and the third leading cause of death globally. Nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are common pathogens in individuals with ...
Adonis D’Mello, Timothy F. Murphy, Martina Wade, Charmaine Kirkham, Yong Kong, Hervé Tettelin, Melinda M. Pettigrew   +6 more
doaj   +2 more sources

Multi-Component Vaccine Candidates Against Non-Typeable Haemophilus influenzae [PDF]

Vaccines
Background: Haemophilus influenzae (Hi), a Gram-negative bacterium, is divided into two broad categories: encapsulated and non-capsulated isolates, also called non-typeable Hi isolates (NTHi).
Nouria Belkacem, Ala-Eddine Deghmane, Muhamed-Kheir Taha   +2 more
doaj   +2 more sources

The safety and efficacy of non-typeable Haemophilus influenzae and Moraxella catarrhalis vaccine in chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials [PDF]

Frontiers in Medicine
BackgroundNon-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are major pathogens implicated in bacterial exacerbations of chronic obstructive pulmonary disease (COPD).
Tiankui Shuai, Tiankui Shuai, Jing Liu, Meijun Dong, Peng Wu, Lu Zhang, Zhouzhou Feng, Wenqiang Li, Jian Liu, Jian Liu   +9 more
doaj   +2 more sources

Exploiting haem-iron dependence of nontypeable Haemophilus influenzae: an avenue for future therapeutic development [PDF]

Frontiers in Cellular and Infection Microbiology
Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that imposes a substantial disease burden, globally. Further amplifying the burden of NTHi-associated infections is the rapidly expanding spectrum and prevalence of antibiotic ...
Brianna Atto, David A. Gell, Robyn Marsh, Robyn Marsh, Stephen Tristram   +4 more
doaj   +2 more sources