Results 1 to 10 of about 6,848 (195)

Dual RNASeq Reveals NTHi-Macrophage Transcriptomic Changes During Intracellular Persistence [PDF]

Frontiers in Cellular and Infection Microbiology, 2021
Nontypeable Haemophilus influenzae (NTHi) is a pathobiont which chronically colonises the airway of individuals with chronic respiratory disease and is associated with poor clinical outcomes.
Ashley Heinson, Myron Christodoulides, T M A Wilkinson   +2 more
exaly   +6 more sources

Relationships between Mucosal Antibodies, Non-Typeable Haemophilus influenzae (NTHi) Infection and Airway Inflammation in COPD [PDF]

PLoS ONE, 2016
Non-typeable Haemophilus influenzae (NTHi) is a key pathogen in COPD, being associated with airway inflammation and risk of exacerbation. Why some patients are susceptible to colonisation is not understood. We hypothesised that this susceptibility may be
Lindsay Welch, Kristoffer Ostridge, Stuart Clarke   +2 more
exaly   +6 more sources

Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi [PDF]

Respiratory Research, 2017
Background Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophages.
Dave Singh, Hannah Metcalfe, Simon Lea   +2 more
exaly   +6 more sources

Haemophilus haemolyticus Interaction with Host Cells Is Different to Nontypeable Haemophilus influenzae and Prevents NTHi Association with Epithelial Cells [PDF]

Frontiers in Cellular and Infection Microbiology, 2016
Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that resides in the upper respiratory tract and contributes to a significant burden of respiratory related diseases in children and adults.
Lea-Ann Kirkham, Peter Richmond, Ruth Thornton   +2 more
exaly   +6 more sources

In Vitro Anti-NTHi Activity of Haemophilin-Producing Strains of Haemophilus haemolyticus

Pathogens, 2020
Nontypeable Haemophilus influenzae (NTHi) is a leading causative organism of opportunistic respiratory tract infections. However, there are currently no effective vaccination strategies, and existing treatments are compromised by antibiotic resistance ...
Brianna Atto, Roger Latham, Dale Kunde, David A Gell, Stephen Tristram   +4 more
doaj   +3 more sources

NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome

Respiratory Research
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations and accelerated ...
Vancheswaran Gopalakrishnan, Ben Sparklin, Jung Hwan Kim, Jerome Bouquet, Margaret Kehl, Tara Kenny, Christopher Morehouse, Carolina Caceres, Paul Warrener, Ventzislava A. Hristova, Susan Wilson, Harini Shandilya, Arnita Barnes, Alexey Ruzin, Junmin Wang, Lisa Oberg, Bastian Angermann, Christopher McCrae, Adam Platt, Daniel Muthas, Sonja Hess, Christine Tkaczyk, Bret R. Sellman, Kristoffer Ostridge, Maria G. Belvisi, Tom M. A. Wilkinson, Karl J. Staples, Antonio DiGiandomenico, on behalf of the MICA II Study Group   +28 more
doaj   +3 more sources

Immunogenicity and safety of the non-typable Haemophilus influenzae–Moraxella catarrhalis (NTHi-Mcat) vaccine administered following the recombinant zoster vaccine versus administration alone: Results from a randomized, phase 2a, non-inferiority trial

Human Vaccines & Immunotherapeutics, 2023
A candidate AS01-adjuvanted vaccine containing four surface proteins from non-typable Haemophilus influenzae and Moraxella catarrhalis (NTHi-Mcat) has been developed to help prevent exacerbations of chronic obstructive pulmonary disease (COPD ...
Ilaria Galgani, Airi Põder, Rain Jõgi, Veli-Jukka Anttila, Stefano Milleri, Alberto M. Borobia, Odile Launay, Marco Testa, Daniela Casula, Luca Grassano, Annaelisa Tasciotti, Marie Dozot, Ashwani K. Arora   +12 more
doaj   +2 more sources

PCV10 elicits Protein D IgG responses in Papua New Guinean children but has no impact on NTHi carriage in the first two years of life

Vaccine, 2021
BACKGROUND Nasopharyngeal colonisation with nontypeable Haemophilus influenzae (NTHi) is associated with development of infections including pneumonia and otitis media.
Peter Jacoby, Lea-Ann Kirkham, Peter Richmond   +2 more
exaly   +2 more sources

Oropharyngeal Carriage of hpl-Containing Haemophilus haemolyticus Predicts Lower Prevalence and Density of NTHi Colonisation in Healthy Adults

Pathogens, 2021
Nontypeable Haemophilus influenzae (NTHi) is a major respiratory pathogen that initiates infection by colonising the upper airways. Strategies that interfere with this interaction may therefore have a clinically significant impact on the ability of NTHi ...
Brianna Atto, Dale Kunde, David A. Gell, Stephen Tristram   +3 more
doaj   +2 more sources

RSV-NTHi Co-Infection Skews Host Immunity by Suppressing Type I IFN Responses and Enhancing Pro-Inflammatory Responses [PDF]

Pathogens
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children, yet determinants of disease severity in otherwise healthy infants remain poorly understood.
Zhinian Zhou, Justin W. Brennan, Ann Lindley Gill, Christopher S. Anderson, Brian M. Ward, Gloria Pryhuber, Thomas J. Mariani, Steven R. Gill, Yan Sun   +8 more
doaj   +2 more sources