Results 21 to 30 of about 6,848 (195)

Acetate-Linked Energy Metabolism as a Determinant of Early Haemophilus influenzae Infection Fitness. [PDF]

Microbiologyopen
The Pta–AckA pathway is critical for Haemophilus influenzae energy generation, metabolic homeostasis, stress resistance, and intracellular colonization, highlighting its potential as a target for management of H. influenzae infections.
Nasreen M, Hosmer J, Munshi SK, Joshi R, Yamamoto A, Schirra HJ, Sly P, McEwan AG, Kappler U.   +8 more
europepmc   +2 more sources

Nontypeable Haemophilus influenzae (NTHi) directly interfere with the regulation of E-cadherin in lung epithelial cells

Microbes and Infection, 2017
Jan Rupp, Goldmann T, Sebastian Marwitz   +2 more
exaly   +2 more sources

Induction of Mucosal IgA–Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel–Based P6 Nasal Vaccine

Frontiers in Immunology, 2022
Nontypeable Haemophilus influenzae (NTHi) strains form a major group of pathogenic bacteria that colonizes the nasopharynx and causes otitis media in young children. At present, there is no licensed vaccine for NTHi.
Rika Nakahashi-Ouchida, Rika Nakahashi-Ouchida, Rika Nakahashi-Ouchida, Hiromi Mori, Hiromi Mori, Yoshikazu Yuki, Yoshikazu Yuki, Yoshikazu Yuki, Shingo Umemoto, Shingo Umemoto, Takashi Hirano, Yohei Uchida, Yohei Uchida, Tomonori Machita, Tomonori Machita, Tomoyuki Yamanoue, Tomoyuki Yamanoue, Shin-ichi Sawada, Masashi Suzuki, Kohtaro Fujihashi, Kohtaro Fujihashi, Kohtaro Fujihashi, Kazunari Akiyoshi, Yuichi Kurono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono   +28 more
doaj   +1 more source

Molecular Epidemiology and Antibiotic Resistance Analysis of Non-Typeable Haemophilus influenzae (NTHi) in Guangzhou: A Representative City of Southern China

Antibiotics, 2023
This study aimed to investigate the molecular epidemiology and antibiotic resistance of Haemophilus influenzae in Guangzhou, China. A total of 80 H. influenzae isolates were collected from the First Affiliated Hospital of Guangzhou Medical University ...
Shuxian Wen, Ying Mai, Xu Chen, Kun Xiao, Yong-Ping Lin, Zhenbo Xu, Ling Yang   +6 more
semanticscholar   +1 more source

Monoclonal antibodies that target extracellular DNABII proteins or the type IV pilus of nontypeable Haemophilus influenzae (NTHI) worked additively to disrupt 2-genera biofilms

Biofilm, 2022
The biofilm state is the preferred lifestyle of bacteria in nature. Within a biofilm, the resident bacteria are protected from environmental stresses, antibiotics and other antimicrobials, including those due to multiple immune effectors of their host ...
Joseph A. Jurcisek, Llwyatt K. Hofer, S. D. Goodman, L. Bakaletz   +3 more
semanticscholar   +1 more source

A detailed analysis of possible efficacy signals of NTHi-Mcat vaccine against severe COPD exacerbations in a previously reported randomised phase 2b trial.

Vaccine, 2022
BACKGROUND An investigational vaccine containing non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) surface proteins did not show vaccine efficacy (VE) against combined moderate and severe (moderate/severe) exacerbations in a ...
A. Arora, K. Chinsky, C. Keller, I. Mayers, Sergi Pascual-Guardia, Mercè Pérez Vera, Christophe Lambert, Stefano Lombardi, S. Rondini, S. Tian, Fernando Ulloa-Montoya, L. Moraschini, D. Casula   +12 more
semanticscholar   +1 more source

Adherence of Nontypeable Haemophilus influenzae to Cells and Substrates of the Airway Is Differentially Regulated by Individual ModA Phasevarions

Microbiology Spectrum, 2023
Adherence of nontypeable Haemophilus influenzae (NTHi) to the host airway is an essential initial step for asymptomatic colonization of the nasopharynx, as well as development of disease.
Preeti Garai, John M. Atack, Brandon M. Wills, Michael P. Jennings, Lauren O. Bakaletz, Kenneth L. Brockman   +5 more
doaj   +1 more source

IL-17C contributes to NTHi-induced inflammation and lung damage in experimental COPD and is present in sputum during acute exacerbations

PLoS ONE, 2021
Neutrophilic inflammation results in loss of lung function in chronic obstructive pulmonary disease (COPD). Gram-negative bacteria, such as nontypeable Haemophilus influenzae (NTHi), trigger acute exacerbations of COPD (AECOPD) and contribute to chronic ...
G. Vella, F. Ritzmann, Lisa Wolf, Andreas Kamyschnikov, H. Stodden, C. Herr, H. Slevogt, R. Bals, C. Beisswenger   +8 more
semanticscholar   +1 more source

NOD2/RICK-dependent β-defensin 2 regulation is protective for nontypeable Haemophilus influenzae-induced middle ear infection. [PDF]

PLoS ONE, 2014
Middle ear infection, otitis media (OM), is clinically important due to the high incidence in children and its impact on the development of language and motor coordination.
Jeong-Im Woo, Sejo Oh, Paul Webster, Yoo Jin Lee, David J Lim, Sung K Moon   +5 more
doaj   +1 more source

Nontypeable Haemophilus influenzae Redox Recycling of Protein Thiols Promotes Resistance to Oxidative Killing and Bacterial Survival in Biofilms in a Smoke-Related Infection Model

mSphere, 2022
Smoke exposure is a risk factor for community-acquired pneumonia, which is typically caused by host-adapted airway opportunists like nontypeable Haemophilus influenzae (NTHi).
Benjamin C. Hunt, Xin Xu, Amit Gaggar, W. Edward Swords   +3 more
doaj   +1 more source