Human Vaccines & Immunotherapeutics, 2023 A candidate AS01-adjuvanted vaccine containing four surface proteins from non-typable Haemophilus influenzae and Moraxella catarrhalis (NTHi-Mcat) has been developed to help prevent exacerbations of chronic obstructive pulmonary disease (COPD ...
Ilaria Galgani +12 more
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Geogenic Particles Induce Bronchial Susceptibility to NTHi
, 2022 Abstract Exposure to geogenic (earth-derived) particulate matter (PM) is linked to an increased prevalence of bronchiectasis and other respiratory infections in Australian Indigenous communities. Experimental studies have shown that the concentration of iron in geogenic PM is associated with the magnitude of respiratory health effects, however,
Lewis J Williams +2 more
openaire +1 more source
The Role of Non-Typeable Haemophilus influenzae Biofilms in Chronic Obstructive Pulmonary Disease
Frontiers in Cellular and Infection Microbiology, 2021 Non-typeable Haemophilus influenzae (NTHi) is an ubiquitous commensal-turned-pathogen that colonises the respiratory mucosa in airways diseases including Chronic Obstructive Pulmonary Disease (COPD).
Jake R. Weeks +9 more
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Intranasal immunization with nontypeable Haemophilus influenzae outer membrane vesicles induces cross-protective immunity in mice. [PDF]
PLoS ONE, 2012 Haemophilus influenzae is a Gram-negative human-restricted bacterium that can act as a commensal and a pathogen of the respiratory tract. Especially nontypeable H.
Sandro Roier +8 more
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Total IgM but not NTHi-specific IgM are increased in the serum of NTHi+ve patients. [PDF]
, 2016 Total IgM in (A) serum or (C) BAL was analysed by MSD multiplex assay. (B) Serum IgM or (D) BAL IgM specific for NTHi was assessed by flow cytometry. Open circles indicate NTHi-ve COPD patients, closed circles indicate NTHi+ve patients.
Stephanie Leung (3368846) +11 more
core +1 more source
Severe Presentation of NontypeableHaemophilus influenzae(NTHi) Infection in a Previously Healthy Toddler [PDF]
Case Reports in Infectious Diseases, 2019 Background. Cellulitis is the inflammation of the skin and subcutaneous tissue. It is usually caused by Gram-positive organisms such asStaphylococcus and Streptococcus pyogenesinfection. NontypeableHaemophilus influenzae(NTHi) is an uncommon cause of cellulitis. Hence, we report on this case.Case Presentation.
Eiman Al Boloushi +3 more
openaire +4 more sources
Total and NTHi-specific IgG1 are decreased in BAL from NTHi+ve patients. [PDF]
, 2016 Total (A) serum IgG1, (B) serum IgG2 (C) serum IgG3 was analysed by MSD multiplex assay. Total (D) IgG1, (E) IgG2 and (F) IgG3 in BAL derived from two lung lobes were analysed by MSD multiplex assay and the average concentration from both lobes is ...
Stephanie Leung (3368846) +11 more
core +1 more source
Adaptive (72 hour) cytokine production to NTHi. [PDF]
, 2014 a) In vitro cytokine production by HC (open circles) and CSLD (filled circles) PBMC following 72 hour challenge with NTHi. Delta concentration (NTHi challenge minus nil challenge) with median and IQR.
John W. Upham (136259) +5 more
core +1 more source
Nontypeable Haemophilus influenzae invasion and persistence in the human respiratory tract
Frontiers in Cellular and Infection Microbiology, 2011 Nontypeable Haemophilus influenzae (NTHI) is an opportunistic bacterial pathogen of the human respiratory tract and is a leading cause of respiratory infections in children and adults.
Cara eClementi, Timothy eMurphy
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NTHi infection induces neutrophilic inflammation in AAD. [PDF]
, 2013 The effect of NTHi infection on BALF neutrophil numbers in AAD was determined (on day 16) and compared to groups with AAD without infection or infection alone without AAD.
Peter G. Gibson (88654) +7 more
core +1 more source