Results 41 to 50 of about 6,848 (195)

Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. [PDF]

PLoS ONE, 2007
Non-typeable Haemophilus influenza (NTHi) is an important human pathogen causing respiratory tract infections in both adults and children. NTHi infections are characterized by inflammation, which is mainly mediated by nuclear transcription factor kappaB (
Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Chang-Hoon Woo, Hajime Ishinaga, Patricia Bourne, Haodong Xu, Un-Hwan Ha, Haidong Xu, Jian-Dong Li   +9 more
doaj   +1 more source

Characterization of a nontypeable Haemophilus influenzae thermonuclease. [PDF]

PLoS ONE, 2018
Nontypeable Haemophilus influenzae (NTHi) has been shown to form biofilms, comprised of extracellular DNA (eDNA), in the middle ear and bronchus during clinical infections.
Christine Cho, Aroon T Chande, Lokesh Gakhar, Jason Hunt, Margaret R Ketterer, Michael A Apicella   +5 more
doaj   +1 more source

A cascade model of dynamic cerebral autoregulation. [PDF]

J Physiol
Abstract figure legend This study examined a two‐component cascade model linking upstream dynamic cerebral autoregulation (dCA) with downstream microvascular function (MF) to explain how blood pressure oscillations influence cortical oxygenation. Transfer function analysis in the frequency domain was applied to quantify H1(f) (MAP→CBFV; dCA), H2(f ...
Kurazumi T, Sharma K, Wennekers RRJ, Tomoto T, Cardim D, Won J, Ashley J, Claassen JAHR, Zhang R.   +8 more
europepmc   +2 more sources

The role of TLR2 and bacterial lipoprotein in enhancing airway inflammation and immunity

Frontiers in Immunology, 2011
Non-typeable Haemophilus influenzae (NTHI) colonizes the lower respiratory tract of patients with chronic obstructive pulmonary disease (COPD) and also causes exacerbations of the disease.
Amit A Lugade, Paul N Bogner, Timothy F Murphy, Yasmin eThanavala   +3 more
doaj   +1 more source

Can non‐typeable Haemophilus influenzae carriage surveillance data infer antimicrobial resistance associated with otitis media?

Pediatric Investigation, 2023
Importance In remote communities of the Northern Territory, Australia, children experience high rates of otitis media (OM), commonly caused by non‐typeable Haemophilus influenzae (NTHi).
Sophia Bowman‐Derrick, Tegan M. Harris, Jemima Beissbarth, Mariana Kleinecke, Katrina Lawrence, Teresa M. Wozniak, Amy Bleakley, Angela Rumaseb, Michael J. Binks, Robyn L. Marsh, Peter S. Morris, Amanda J. Leach, Heidi Smith‐Vaughan   +12 more
doaj   +1 more source

Non-typeable Haemophilus influenzae major outer membrane protein P5 contributes to bacterial membrane stability, and affects the membrane protein composition crucial for interactions with the human host

Frontiers in Cellular and Infection Microbiology, 2023
Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human pathogen that causes a wide range of airway diseases. NTHi has a plethora of mechanisms to colonize while evading the host immune system for the establishment of infection. We previously
Yu-Ching Su, Mahendar Kadari, Megan L. Straw, Martina Janoušková, Sandra Jonsson, Oskar Thofte, Farshid Jalalvand, Erika Matuschek, Linda Sandblad, Ákos Végvári, Roman A. Zubarev, Kristian Riesbeck   +11 more
doaj   +1 more source

Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media

International Journal of Molecular Medicine, 2018
Otitis media is one of the most common bacterial infections in children, contributing to hearing loss. A vital bacterial pathogen leading to otitis media development is the nontypeable Haemophilus influenzae (NTHi).
Yu-Kun Ma, Yu-Bin Chen, Peng Li
semanticscholar   +1 more source

Total IgM but not NTHi-specific IgM are increased in the serum of NTHi+ve patients.

, 2016
Total IgM in (A) serum or (C) BAL was analysed by MSD multiplex assay. (B) Serum IgM or (D) BAL IgM specific for NTHi was assessed by flow cytometry. Open circles indicate NTHi-ve COPD patients, closed circles indicate NTHi+ve patients.
Stephanie Leung (3368846), Tom M. A. Wilkinson (702971), Kristoffer Ostridge (3368855), Stuart C. Clarke (415927), Andrew Gorringe (3368852), Andrew C. Tuck (3368843), Thierry G. Pascal (3368849), Karl J. Staples (457228), Stephen Taylor (81177), Steve Thomas (11698), Karen Cox (67096), Lindsay Welch (3368858)   +11 more
core   +1 more source

Lung Surfactant Lipids Provide Immune Protection Against Haemophilus influenzae Respiratory Infection

Frontiers in Immunology, 2019
Non-typeable Haemophilus influenzae (NTHi) causes persistent respiratory infections in patients with chronic obstructive pulmonary disease (COPD), probably linked to its capacity to invade and reside within pneumocytes.
Belén García-Fojeda, Belén García-Fojeda, Zoe González-Carnicero, Alba de Lorenzo, Carlos M. Minutti, Carlos M. Minutti, Lidia de Tapia, Begoña Euba, Begoña Euba, Alba Iglesias-Ceacero, Sonia Castillo-Lluva, Junkal Garmendia, Junkal Garmendia, Cristina Casals, Cristina Casals   +14 more
doaj   +1 more source

Epithelial immune activation and intracellular invasion by non-typeable Haemophilus influenzae

Frontiers in Cellular and Infection Microbiology, 2023
Type-2 low asthma affects 30-50% of people with severe asthma and includes a phenotype characterized by sputum neutrophilia and resistance to corticosteroids. Airways inflammation in type-2 low asthma or COPD is potentially driven by persistent bacterial
Mary A. Brown, Sophie B. Morgan, Gillian E. Donachie, Katie L. Horton, Ian D. Pavord, Carolina V. Arancibia-Cárcamo, Timothy S. C. Hinks   +6 more
doaj   +1 more source