Results 61 to 70 of about 6,848 (195)
cMat, Volume 3, Issue 3, September 2026.Polyphenol assembly chemistry provides a versatile basis for antibacterial biomaterials. Matching material format and function to the distinct barriers of wound, respiratory, intestinal, and implant‐associated infections is central to effective and translatable design. ABSTRACT Bacterial infections involving multidrug‐resistant pathogens and persistent
Wei Yang +4 more
wiley +1 more source
PLoS ONE, 2016 We have established an in vitro 3D system which recapitulates the human tracheo-bronchial mucosa comprehensive of the pseudostratified epithelium and the underlying stromal tissue. In particular, we reported that the mature model, entirely constituted of
Pasquale Marrazzo +6 more
semanticscholar +1 more source
Allergy, Volume 81, Issue 9, Page 3221-3235, September 2026.This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake +8 more
wiley +1 more source
NTHi-IAV coinfection of macrophages alters infection outcomes and inflammatory responses
, 2022 Nontypeable Haemophilus influenzae (NTHi) chronically colonises the airway of individuals with chronic respiratory disease, with persistence suggested to be facilitated by invasion of airway macrophages. Previous data supports an interaction between NTHi
Christodoulides, Myron +6 more
core +1 more source
Scientific Reports, 2016 Otitis media (OM) is the most common childhood bacterial infection and leading cause of conductive hearing loss. Nontypeable Haemophilus influenzae (NTHi) is a major bacterial pathogen for OM.
Anuhya S. Konduru +2 more
semanticscholar +1 more source
On the Alternative Protonation of Heterocyclic Michler´s Ketone Analogues
ChemistrySelect, Volume 11, Issue 32, 24 August 2026.Bis(5‐aminothionyl)ketones exhibit a significant bathochromic shift in the UV–vis absorption spectrum and form deeply violet proton adducts under acidic conditions. NMR spectroscopy and quantum chemical calculations confirm that O‐protonation occurs. In contrast, protonation of the amino groups in Michler´s ketone and the heterocyclic aza moieties in ...
Evgenia Dmitrieva +2 more
wiley +1 more source
Correlation of NTHi-specific antibody binding with oxidative burst assay.
, 2016 Spearman’s correlation of NTHi-specific (A) total IgG binding with IgG specific oxidative burst assay (OBA) and (B) total IgA binding with IgA specific OBA in serum with rho and p value presented.
Stephanie Leung (3368846) +11 more
core +1 more source
Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria. [PDF]
PLoS ONE, 2013 Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g.
Di Jiang +5 more
doaj +1 more source
Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease
Food Science &Nutrition, Volume 14, Issue 7, July 2026.This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley +1 more source
Distribution of sequenced NTHi isolates.
, 2015 Neighbor joining dendogram of NTHi strains used in this study. The tree is rooted with Eschericia coli MG1655 and is based on sequence comparisons of the concatenated adk, pgi, recA, infB and 16s rRNA gene sequences, with bootstrap values of greater than
Daniel J. Morton (296237) +3 more
core +1 more source