Results 71 to 80 of about 4,073 (199)
PMA synergistically enhances NTHi-induced MUC5AC expression via MKK3/6-p38 MAPK pathway. [PDF]
, 2013 (A) PMA synergistically enhanced NTHi-induced phosphorylation of p38 MAPK and MKK3/6, but not ERK and MEK1. (B) The synergistic induction of MUC5AC transcription by NTHi and PMA was inhibited by overexpressing DN mutant forms of p38α and p38β in human ...
Hirofumi Jono (35203) +3 more
core +1 more source
MicrobiologyOpen, 2018 Biofilms play a central role in the pathobiology of otitis media (OM), bronchitis, sinusitis, conjunctivitis, and pneumonia caused by nontypeable Haemophilus influenzae (NTHI).
Aishwarya Devaraj +4 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2012 Nontypeable Haemophilus influenzae (NTHi) is a common airway commensal and opportunistic pathogen that persists within surface-attached biofilm communities.
Bing ePang +3 more
doaj +1 more source
Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi [PDF]
Proceedings of the National Academy of Sciences, 2015 SignificanceChronic obstructive pulmonary disease (COPD) is the fourth-leading cause of death worldwide. Roflumilast has been approved for COPD. However, its efficacy has been hampered by the development of tolerance, and the underlying mechanism remains unknown but may be attributed to phosphodiesterase (PDE) 4B up-regulation.
Seiko, Susuki-Miyata +6 more
openaire +2 more sources
mBio, 2012 Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative, human-restricted pathogen. Although this bacterium typically colonizes the nasopharynx in the absence of clinical symptoms, it is also one of the major pathogens causing otitis media (OM) in ...
Jeroen D. Langereis +8 more
doaj +1 more source
Human neutrophil elastase degrades SPLUNC1 and impairs airway epithelial defense against bacteria. [PDF]
PLoS ONE, 2013 Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant cause of mortality of COPD patients, and pose a huge burden on healthcare. One of the major causes of AECOPD is airway bacterial (e.g.
Di Jiang +5 more
doaj +1 more source
mSphere, 2019 Biofilms formed by nontypeable Haemophilus influenzae (NTHI) bacteria play an important role in multiple respiratory tract diseases. Visual inspection of the morphology of biofilms formed during chronic infections shows distinct differences from biofilms
Jonathan R. Brown +7 more
doaj +1 more source
APMIS, Volume 134, Issue 4, April 2026.ABSTRACT The emergence of cefotaxime‐resistant Haemophilus influenzae (CRHI) in Norway during the 2000s coincided with increased use of oral aminopenicillins and parenteral third‐generation cephalosporins. This study examined associations between beta‐lactam consumption and CRHI incidence. Surveillance data on antibiotic usage across Norwegian regions (
Dagfinn Skaare, Gunnar Skov Simonsen
wiley +1 more source
A detailed analysis of possible efficacy signals of NTHi-Mcat vaccine against severe COPD exacerbations in a previously reported randomised phase 2b trial [PDF]
, 2022 Background: An investigational vaccine containing non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) surface proteins did not show vaccine efficacy (VE) against combined moderate and severe (moderate/severe) exacerbations in a ...
Arora, Ashwani K. +13 more
core +1 more source
PI3K/Akt mediates EGFR-dependent inflammation induced by NTHi in middle ear epithelial cells. [PDF]
, 2013 (A) Cells were incubated with NTHi with or without wortmannin, and NTHi-induced NF-κB activation was measured by performing luciferase assay. (B) Cells were incubated with NTHi with or without wortmannin, and whole cell protein was collected and blotted ...
Xiangbin Xu (338925) +9 more
core +1 more source