Results 91 to 100 of about 4,073 (199)

Resveratrol suppresses NTHi-induced inflammation via up-regulation of the negative regulator MyD88 short [PDF]

Scientific Reports, 2016
AbstractUpper respiratory tract inflammatory diseases such as asthma and chronic obstructive pulmonary diseases (COPD) affect more than one-half billion people globally and are characterized by chronic inflammation that is often exacerbated by respiratory pathogens such as nontypeable Haemophilus influenzae (NTHi).
Carla S. Andrews, Shingo Matsuyama, Byung-Cheol Lee, Jian-Dong Li   +3 more
openaire   +2 more sources

NTHi biofilms protect against a lethal dose of cefuroxime. [PDF]

, 2014
Biofilms of NTHi strains 2019 and PittGG were formed overnight in the absence of antibiotic (Untreated), or in the presence of 170 ng/mL ampicillin (AMP), 230 ng/mL amoxicillin (AMOX) or 170 ng/mL cefuroxime (CEF).
Charles Wang (242565), Christoph Schaudinn (57882), Kathleen Maguire (595256), Paul Webster (56402), Xiaojin Li (152688), Siva Wu (588646), Debbie Guerrero-Given (588647), Marc M. Baum (471040), Manjula Gunawardana (471035)   +8 more
core   +1 more source

Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae

mBio, 2017
Biofilms formed in the middle ear by nontypeable Haemophilus influenzae (NTHI) are central to the chronicity, recurrence, and refractive nature of otitis media (OM).
Jayajit Das, Elaine Mokrzan, Vinal Lakhani, Lucia Rosas, Joseph A. Jurcisek, William C. Ray, Lauren O. Bakaletz   +6 more
doaj   +1 more source

NTHi induces inflammatory response through TLR2-MyD88-TRAF6/7-NF-κB signaling pathway. [PDF]

, 2013
A & B, Overexpressing dominant-negative (DN) mutants of TLR2, MyD88 and TRAF6/7 inhibited NTHi-induced activation of NF-κB (A) and up-regulation of IL-1β and IL-8 (B) in HMEEC-1 cells ...
Hirofumi Jono (35203), Jian-Dong Li (35211), Haodong Xu (35208), Tomoaki Koga (35204), Jae Hyang Lim (35202), Chang-Hoon Woo (35205), Hajime Ishinaga (35206), Haidong Xu (35210), Patricia Bourne (35207), Un-Hwan Ha (35209)   +9 more
core   +1 more source

Detection of Cell-Dissociated Non-Typeable Haemophilus influenzae in the Airways of Patients with Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2020
Samantha J Thulborn,1,2 Alessandro Ceroni,3 Koirobi Haldar,4 Vijay Mistry,4 Jennifer L Cane,1,2 Christopher E Brightling,4,5 Michael R Barer,4 Mona Bafadhel1 1Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK ...
Thulborn SJ, Ceroni A, Haldar K, Mistry V, Cane JL, Brightling CE, Barer MR, Bafadhel M   +7 more
doaj  

Infectious Triggers and Immune Dynamics in Guillain–Barré Syndrome: Revisiting Campylobacter jejuni and the Silent Role of Haemophilus influenzae

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Schematic representation of the gut‐brain axis and microbial triggers in Guillain–Barré Syndrome. Post‐infectious immune responses, particularly through molecular mimicry by pathogens, such as Campylobacter jejuni and Haemophilus influenzae, lead to demyelination and subsequent neuromuscular paralysis.
Aswathi Ramesh, Rajasekaran Subbarayan, Dhasarathdev Srinivasan, Ranjith Balakrishnan, Rupendra Shrestha, Ankush Chauhan   +5 more
wiley   +1 more source

Developing a nontypeable Haemophilus influenzae (NTHi) vaccine [PDF]

, 2001
There is a current high demand for nontypable Haemophilus influenzae (NTHi) vaccines. Various options for the composition of such vaccines are possible.
A Forsgren (9895859), Cripps, Allan W., Bakaletz, Lauren O., Jennelle Kyd (9811673), Forsgren, Arne., A Cripps (9859400), Kyd, Jennelle M., J Poolman (9895853), Denoel, Philippe A., P Denoel (9895856), Lobet, Yves., L Bakaletz (9881840), Poolman, Jan Theunis., Y Lobet (9895862)   +13 more
core  

Detection of M. catarrhalis and NTHI in biofilms recovered from the chinchilla middle ear. [PDF]

, 2013
Immunofluorescence image of a biofilm incubated with rabbit-anti NTHI outer membrane protein P5 (green), mouse anti-M. catarrhalis PilA (red), and stained with DAPI to label DNA (blue). A) Merged image, B) M.
Martha R. Bowers (317741), Lauren O. Bakaletz (240363), Laura A. Novotny (317739), Glen McGillivary (240361), Joseph A. Jurcisek (317740), M. Elizabeth Brockson (301571)   +5 more
core   +1 more source

Otitis Media Trial Publication After ClinicalTrials.gov Registration

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 4, Page 882-887, October 2025.
Abstract Objective To evaluate the proportion of completed otitis media (OM) clinical trials registered on ClinicalTrials.gov and identify factors associated with nonpublication. Study Design Cross‐sectional observational study. Setting ClinicalTrials.gov registry and peer‐reviewed literature databases.
Michael Oca, Suraj M. Rajan, Z. Jason Qian   +2 more
wiley   +1 more source

PMA synergizes with NTHi to induce MUC5AC expression in human epithelial cell. [PDF]

, 2013
(A) PMA synergistically enhanced NTHi-induced MUC5AC expression at the mRNA level in human epithelial HM3 cell, as assessed by performing RT-PCR (left panel) and real-time quantitative PCR (Q-PCR) analysis (right panel). Cyclophilin was used as a control
Hirofumi Jono (35203), Jian-Dong Li (35211), Jae Hyang Lim (35202), Haidong Xu (35210)   +3 more
core   +1 more source