Proposed model for host-mediated nutritional environment effects on NTHI pathogenesis. [PDF]
, 2013 NTHI (dark green bacteria) asymptomatically colonizes the heme-iron sufficient nasopharynx epithelium (orange cells) (A). Permissive factors promote ascension up the Eustachian tube to the intact middle ear epithelium (brown cells) where NTHI are heme ...
Blake R. Szelestey (469458) +4 more
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mSphere, 2018 Nutrient limitation restricts bacterial growth in privileged sites such as the middle ear. Transient heme-iron restriction of nontypeable Haemophilus influenzae (NTHI), the major causative agent of chronic and recurrent otitis media (OM), promotes new ...
Rachael L. Hardison +8 more
doaj +1 more source
TLR2 is involved in the synergistic enhancement of NTHi-induced MUC5AC expression by PMA. [PDF]
, 2013 (A) Overexpression of a DN mutant form of TLR2 inhibited the synergistic induction of MUC5AC transcription by NTHi and PMA in human epithelial cells, as assessed by MUC5AC-dependent promoter Luciferase assay. Cells were transfected with 0.8 µg of DN TLR2
Hirofumi Jono (35203) +3 more
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NTHi infection suppressed systemic IL-13 and IFN-γ responses in AAD. [PDF]
, 2013 Groups of mice were infected during (d0 NTHi+OVA) or 10 days after (d10 NTHi+OVA) OVA sensitization, and AAD was analyzed (on day 16). The effect of infection on IL-5 (A), IL-13 (B), and IFN-γ (C) release from splenocytes stimulated with OVA was assessed.
Peter G. Gibson (88654) +7 more
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NTHi-induced CYLD is responsible for down-regulation of inflammatory response. [PDF]
, 2013 A & B, NTHi induced CYLD expression at both mRNA (A) and protein levels (B) in HMEEC-1 cells. C, NTHi induced CYLD expression at the mRNA level in the middle ear of WT mice.
Hirofumi Jono (35203) +9 more
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The roles of phosphocholine expressed on NTHi bacteria and host CRP in acute otitis media
, 2022 Otitis Media (OM) is inflammation of the middle ear (ME). Non-typeable Haemophilus influenzae (NTHi) is one of the leading otopathogens causing OM. Phosphocholine (PCho) on the NTHi lipopolysaccharide influences host-pathogen interaction. C-Reactive Protein (CRP), an acute phase protein, recognizes PCho and can mediate bacterial killing.
openaire +2 more sources
NTHi is a potent stimulator of innate inflammatory mediators regardless of susceptibility to OM. [PDF]
, 2018 PBMC from otitis-prone children (cases; black dots) or non-otitis-prone children (controls; grey squares) were challenged with NTHi 86-028NP (NTHi-86), NTHi 289 or SEB and cytokine secretion was measured at 4h (left panel) or 24h (right panel) post ...
Dino Tan (5066372) +6 more
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Heme-iron status influences disease severity of NTHI. [PDF]
, 2013 Middle ear pressure was measured by tympanometry (mean ± S.D.) on each day following transbullar introduction of heme-iron replete (black squares) or restricted (gray circles) NTHI (A).
Blake R. Szelestey (469458) +4 more
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The pomegranate-derived peptide Pug-4 alleviates nontypeable Haemophilus influenzae-induced inflammation by suppressing NF-kB signaling and NLRP3 inflammasome activation [PDF]
PeerJThe respiratory pathogen nontypeable Haemophilus influenzae (NTHi) is the most common cause of exacerbation of chronic obstructive pulmonary disease (COPD), of which an excessive inflammatory response is a hallmark.
Pornpimon Jantaruk +3 more
doaj +2 more sources
EGFR mediates NTHi-induced NF-κB transcriptional activity in a variety of cell types. [PDF]
, 2013 (A–D) The effect of AG1478 on NTHi-induced NF-κB activation was evaluated by performing luciferase assay in HMEEC-1 (A), A549 (B), HeLa (C) and RAW 264.7(D).
Xiangbin Xu (338925) +9 more
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