Strain-dependent effects of Nontypeable Haemophilus influenzae (NTHi) on human macrophage function
, 2019 Nontypeable Haemophilus influenzae (NTHi) is a heterogeneous respiratory tract pathogen implicated in opportunistic infections and exacerbations of chronic respiratory diseases, such as COPD and asthma. In these diseases, airway macrophages have impaired
Jodie Ackland +10 more
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Cytokine secretion in murine macrophages after stimulation with non-viable NTHi.
, 2013 Murine macrophages were stimulated with inactivated NTHi for 24 h. IL-1β concentrations were significantly reduced compared to stimulation with viable NTHi (A).
Peter Kujath (427192) +6 more
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In vitro anti-NTHi activity of haemophilin-producing strains of Haemophilus haemolyticus
, 2020 Nontypeable Haemophilus influenzae (NTHi) is a leading causative organism of opportunistic respiratory tract infections. However, there are currently no effective vaccination strategies, and existing treatments are compromised by antibiotic resistance ...
David Gell (14737321) +4 more
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TLR-TRAF6-dependent synergistic MUC5AC induction by NTHi and PMA is mediated by PKCθ.
, 2013 (A) Rottlerin, a specific PKC™/θ inhibitor, blocked the synergistic induction of MUC5AC transcription by NTHi and PMA in human epithelial cells, as assessed by MUC5AC-dependent promoter Luciferase assay.
Hirofumi Jono (35203) +3 more
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RV infection prolongs lung inflammation caused by NTHi and suppresses initial chemokine response.
, 2012 Mice were infected with sham or RV followed by NTHi as described in Figure 1. (A and B) Hematoxylin and eosin stained lung sections from Sham/NTHi-infected mice at 1 and 3 days post NTHi infection respectively. (C to E) Hematoxylin and eosin stained lung
Benjamin L. Unger (130418) +5 more
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The pomegranate-derived peptide Pug-4 alleviates nontypeable Haemophilus influenzae-induced inflammation by suppressing NF-kB signaling and NLRP3 inflammasome activation [PDF]
PeerJThe respiratory pathogen nontypeable Haemophilus influenzae (NTHi) is the most common cause of exacerbation of chronic obstructive pulmonary disease (COPD), of which an excessive inflammatory response is a hallmark.
Pornpimon Jantaruk +3 more
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NTHi induces inflammatory response through TLR2-MyD88-TRAF6/7-NF-κB signaling pathway.
, 2013 A & B, Overexpressing dominant-negative (DN) mutants of TLR2, MyD88 and TRAF6/7 inhibited NTHi-induced activation of NF-κB (A) and up-regulation of IL-1β and IL-8 (B) in HMEEC-1 cells ...
Hirofumi Jono (35203) +9 more
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Frontiers in MedicineBackgroundNon-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) are major pathogens implicated in bacterial exacerbations of chronic obstructive pulmonary disease (COPD).
Tiankui Shuai +9 more
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Developing a nontypeable Haemophilus influenzae (NTHi) vaccine
, 2001 There is a current high demand for nontypable Haemophilus influenzae (NTHi) vaccines. Various options for the composition of such vaccines are possible.
A Forsgren (9895859) +13 more
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PMA synergizes with NTHi to induce MUC5AC expression in human epithelial cell.
, 2013 (A) PMA synergistically enhanced NTHi-induced MUC5AC expression at the mRNA level in human epithelial HM3 cell, as assessed by performing RT-PCR (left panel) and real-time quantitative PCR (Q-PCR) analysis (right panel). Cyclophilin was used as a control
Hirofumi Jono (35203) +3 more
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