Results 101 to 110 of about 6,848 (195)

Infectious Triggers and Immune Dynamics in Guillain–Barré Syndrome: Revisiting Campylobacter jejuni and the Silent Role of Haemophilus influenzae

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
Schematic representation of the gut‐brain axis and microbial triggers in Guillain–Barré Syndrome. Post‐infectious immune responses, particularly through molecular mimicry by pathogens, such as Campylobacter jejuni and Haemophilus influenzae, lead to demyelination and subsequent neuromuscular paralysis.
Aswathi Ramesh, Rajasekaran Subbarayan, Dhasarathdev Srinivasan, Ranjith Balakrishnan, Rupendra Shrestha, Ankush Chauhan   +5 more
wiley   +1 more source

Otitis Media Trial Publication After ClinicalTrials.gov Registration

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 4, Page 882-887, October 2025.
Abstract Objective To evaluate the proportion of completed otitis media (OM) clinical trials registered on ClinicalTrials.gov and identify factors associated with nonpublication. Study Design Cross‐sectional observational study. Setting ClinicalTrials.gov registry and peer‐reviewed literature databases.
Michael Oca, Suraj M. Rajan, Z. Jason Qian   +2 more
wiley   +1 more source

β‐Lactamase‐Producing Haemophilus influenzae Pneumonia in a 1‐Month‐Old Infant With Respiratory Syncytial Virus Bronchiolitis

Journal of General and Family Medicine, Volume 27, Issue 3, May 2026.
Kazumasa Zensho, Naoki Nojima, Ryoma Hino, Naohi Isse   +3 more
wiley   +1 more source

Microsatellite Instability in the Tumor Microenvironment: The Role of Inflammation and the Microbiome

Cancer Medicine, Volume 14, Issue 8, April 2025.
The microbiome, an environmental factor, can contribute to DNA damage and affect mutation accumulation. Infections with genotoxin‐producing pathobionts can induce inflammation and oxidative stress through reactive nitrogen and oxygen species, which may influence MSI.
Elizabeth Vargas‐Castellanos, Andrés Rincón‐Riveros   +1 more
wiley   +1 more source

Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B

Respiratory Research, 2008
Background Nontypeable Haemophilus influenzae (NTHi) is an important respiratory pathogen implicated as an infectious trigger in chronic obstructive pulmonary disease, but its molecular interaction with human lung epithelial cells remains unclear. Herein,
Koga Tomoaki, Lim Jae-Hyang, Wu Zuqun, Zhang Rong, Xu Zhihao, Xu Feng, Li Jian-Dong, Shen Huahao   +7 more
doaj   +1 more source

Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates

Vaccine, 2009
We designed and tested three PilA-derived vaccine candidates in a chinchilla model of ascending nontypeable Haemophilus influenzae (NTHI)-induced otitis media (OM).
L. Novotny, Leanne D. Adams, D. R. Kang, Gregory J. Wiet, Xue-Ya Cai, S. Sethi, T. Murphy, L. Bakaletz   +7 more
semanticscholar   +1 more source

PMA synergistically enhances TLR-dependent MUC5AC induction by NTHi via TRAF6.

, 2013
(A) PMA synergistically enhanced NTHi-induced polyubiquitination of TRAF6 in human epithelial cells. Cells were transfected with TRAF6, and were treated with NTHi and PMA as indicated.
Hirofumi Jono (35203), Jian-Dong Li (35211), Jae Hyang Lim (35202), Haidong Xu (35210)   +3 more
core   +1 more source

Transient Nutrient Deprivation Promotes Macropinocytosis-Dependent Intracellular Bacterial Community Development

mSphere, 2018
Nutrient limitation restricts bacterial growth in privileged sites such as the middle ear. Transient heme-iron restriction of nontypeable Haemophilus influenzae (NTHI), the major causative agent of chronic and recurrent otitis media (OM), promotes new ...
Rachael L. Hardison, Derek R. Heimlich, Alistair Harrison, Wandy L. Beatty, Sarah Rains, M. Arthur Moseley, J. Will Thompson, Sheryl S. Justice, Kevin M. Mason   +8 more
doaj   +1 more source

PMA synergistically enhances NTHi-induced MUC5AC expression via MKK3/6-p38 MAPK pathway.

, 2013
(A) PMA synergistically enhanced NTHi-induced phosphorylation of p38 MAPK and MKK3/6, but not ERK and MEK1. (B) The synergistic induction of MUC5AC transcription by NTHi and PMA was inhibited by overexpressing DN mutant forms of p38α and p38β in human ...
Hirofumi Jono (35203), Jian-Dong Li (35211), Jae Hyang Lim (35202), Haidong Xu (35210)   +3 more
core   +1 more source

PI3K/Akt mediates EGFR-dependent inflammation induced by NTHi in middle ear epithelial cells.

, 2013
(A) Cells were incubated with NTHi with or without wortmannin, and NTHi-induced NF-κB activation was measured by performing luciferase assay. (B) Cells were incubated with NTHi with or without wortmannin, and whole cell protein was collected and blotted ...
Xiangbin Xu (338925), Jian-Dong Li (35211), Jae Hyang Lim (35202), Sanjay B. Maggirwar (244853), Jinjiang Pang (338931), Christine A. Fedorchuk (338929), Zhixing K. Pan (338932), Haidong Xu (35210), Rachel R. Steere (338927), Ji-Yun Lee (230138)   +9 more
core   +1 more source