Results 11 to 20 of about 4,073 (199)

In Vitro Anti-NTHi Activity of Haemophilin-Producing Strains of Haemophilus haemolyticus [PDF]

Pathogens, 2020
Nontypeable Haemophilus influenzae (NTHi) is a leading causative organism of opportunistic respiratory tract infections. However, there are currently no effective vaccination strategies, and existing treatments are compromised by antibiotic resistance ...
Brianna Atto, Roger Latham, Dale Kunde, David A Gell, Stephen Tristram   +4 more
doaj   +5 more sources

NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome [PDF]

Respiratory Research
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by airway obstruction and inflammation. Non-typeable Haemophilus influenzae (NTHi) lung infections are common in COPD, promoting frequent exacerbations and accelerated ...
Vancheswaran Gopalakrishnan, Ben Sparklin, Jung Hwan Kim, Jerome Bouquet, Margaret Kehl, Tara Kenny, Christopher Morehouse, Carolina Caceres, Paul Warrener, Ventzislava A. Hristova, Susan Wilson, Harini Shandilya, Arnita Barnes, Alexey Ruzin, Junmin Wang, Lisa Oberg, Bastian Angermann, Christopher McCrae, Adam Platt, Daniel Muthas, Sonja Hess, Christine Tkaczyk, Bret R. Sellman, Kristoffer Ostridge, Maria G. Belvisi, Tom M. A. Wilkinson, Karl J. Staples, Antonio DiGiandomenico, on behalf of the MICA II Study Group   +28 more
doaj   +6 more sources

Dual RNASeq unveils NTHi-macrophage transcriptomic changes during intracellular persistence [PDF]

Respiratory infections, 2020
Nontypeable Haemophilus influenzae (NTHi) is a respiratory tract pathogen associated with severe, neutrophilic asthma. Although macrophages are responsible for orchestrating the immune response and pathogen clearance in the lung, NTHi is able to persist within macrophages. The mechanism of NTHi intracellular persistence is not understood, therefore the
Jodie Ackland, Ashley Heinson, David Cleary, Myron Christodoulides, Tom Wilkinson, Karl Staples   +5 more
core   +5 more sources

NTHi-IAV coinfection of macrophages alters infection outcomes and inflammatory responses [PDF]

Respiratory infections and bronchiectasis, 2022
Nontypeable Haemophilus influenzae (NTHi) chronically colonises the airway of individuals with chronic respiratory disease, with persistence suggested to be facilitated by invasion of airway macrophages. Previous data supports an interaction between NTHi
Jodie Ackland, Ashley Heinson, David Cleary, Myron Christodoulides, Tom Wilkinson, Karl Staples   +5 more
openaire   +2 more sources

The Potency of NTHi lic1A Gene as a Biomarker in Determining The Severity of Post-Viral Acute Rhinosinusitis

Indonesian Biomedical Journal, 2021
BACKGROUND: The lic1A gene is an important virulence factor for non-typeable H. influenzae (NTHi), which allows its translocation from the nasopharynx into the sinonasal cavity and modulates more severe inflammatory processes.
Imam Megantara, Ronny Lesmana, Nova Sylviana, Sunarjati Soedigdoadi, Teti Madiadipoera   +4 more
doaj   +3 more sources

Macrophage inflammatory responses to Non-typeable Haemophilus influenzae (NTHi) are strain-dependent [PDF]

Respiratory infections, 2019
The airway macrophage is crucial for immune surveillance and pathogen clearance, however, this function is impaired in chronic respiratory diseases such as COPD and asthma. This may lead to colonization of the airways by Nontypeable Haemophilus influenzae (NTHi).
Jodie Ackland, Karen Osman, C. Mirella Spalluto, David W Cleary, Myron Christodoulides, Tom Wilkinson, Karl J Staples   +6 more
openaire   +2 more sources

Chorioamnionitis in the Second Trimester Secondary to Multidrug-Resistant <i>Haemophilus influenzae</i> Infection. [PDF]

Case Rep Infect Dis
Purpose Nontypeable Haemophilus influenzae (NTHi) is an emerging perinatal pathogen linked to chorioamnionitis, preterm birth, and early pregnancy loss. This case report describes the presentation, microbiologic findings, and management of second‐trimester NTHi‐associated chorioamnionitis, emphasizing diagnostic challenges and antimicrobial ...
Carlson KS, Korthals MB.
europepmc   +2 more sources

Acetate-Linked Energy Metabolism as a Determinant of Early Haemophilus influenzae Infection Fitness. [PDF]

Microbiologyopen
The Pta–AckA pathway is critical for Haemophilus influenzae energy generation, metabolic homeostasis, stress resistance, and intracellular colonization, highlighting its potential as a target for management of H. influenzae infections.
Nasreen M, Hosmer J, Munshi SK, Joshi R, Yamamoto A, Schirra HJ, Sly P, McEwan AG, Kappler U.   +8 more
europepmc   +2 more sources

The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma [PDF]

Respiratory Research, 2020
AbstractAsthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are described as persistent, more severe and corticosteroid-resistant, with higher hospitalization and mortality rates, which seriously affect the lives of asthmatic patients.
Jing Zhang, Zhenxing Zhu, Xu Zuo, He Pan, Yinuo Gu, Yuze Yuan, Guoqiang Wang, Shiji Wang, Ruipeng Zheng, Zhongmin Liu, Fang Wang, Jingtong Zheng   +11 more
openaire   +3 more sources

Induction of Mucosal IgA–Mediated Protective Immunity Against Nontypeable Haemophilus influenzae Infection by a Cationic Nanogel–Based P6 Nasal Vaccine

Frontiers in Immunology, 2022
Nontypeable Haemophilus influenzae (NTHi) strains form a major group of pathogenic bacteria that colonizes the nasopharynx and causes otitis media in young children. At present, there is no licensed vaccine for NTHi.
Rika Nakahashi-Ouchida, Rika Nakahashi-Ouchida, Rika Nakahashi-Ouchida, Hiromi Mori, Hiromi Mori, Yoshikazu Yuki, Yoshikazu Yuki, Yoshikazu Yuki, Shingo Umemoto, Shingo Umemoto, Takashi Hirano, Yohei Uchida, Yohei Uchida, Tomonori Machita, Tomonori Machita, Tomoyuki Yamanoue, Tomoyuki Yamanoue, Shin-ichi Sawada, Masashi Suzuki, Kohtaro Fujihashi, Kohtaro Fujihashi, Kohtaro Fujihashi, Kazunari Akiyoshi, Yuichi Kurono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono   +28 more
doaj   +1 more source