Phasevarion Mediated Epigenetic Gene Regulation in Helicobacter pylori [PDF]
PLoS ONE, 2011 Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression). In Haemophilus influenzae and pathogenic Neisseria, the random
Roy Robins-Browne +2 more
exaly +12 more sources
Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae [PDF]
Infection and Immunity, 2017 ABSTRACT Kingella kingae is a common etiological agent of pediatric osteoarticular infections. While current research has expanded our understanding of K. kingae pathogenesis, there is a paucity of knowledge about host-pathogen interactions and virulence gene regulation.
Georgina Pollock +2 more
exaly +8 more sources
ModA2 Phasevarion Switching in NontypeableHaemophilus influenzaeIncreases the Severity of Experimental Otitis Media [PDF]
Journal of Infectious Diseases, 2016 Several human-adapted bacterial pathogens use a phasevarion (ie, a phase-variable regulon) to rapidly and reversibly regulate the expression of many genes, which include known virulence factors, yet the influence of phasevarion-mediated regulation in pathogenesis remains poorly understood.
Lauren Bakaletz +2 more
exaly +10 more sources
Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies [PDF]
Trends in Microbiology, 2018 A wide variety of bacterial pathogens express phase-variable DNA methyltransferases that control expression of multiple genes via epigenetic mechanisms.
Lauren Bakaletz +2 more
exaly +9 more sources
Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori [PDF]
Scientific Reports, 2017 The Helicobacter pylori phase variable gene modH, typified by gene HP1522 in strain 26695, encodes a N6-adenosine type III DNA methyltransferase. Our previous studies identified multiple strain-specific modH variants (modH1 – modH19) and showed that ...
Michael P Jennings +2 more
exaly +10 more sources
The modA10 phasevarion of nontypeable Haemophilus influenzae R2866 regulates multiple virulence-associated traits [PDF]
Microbial Pathogenesis, 2016 Non-typeable Haemophilus influenzae (NTHi) is a human restricted commensal and pathogen that elicits inflammation by adhering to and invading airway epithelia cells: transcytosis across these cells can result in systemic infection.
Michael P Jennings +2 more
exaly +11 more sources
Phasevarions mediate random switching of gene expression in pathogenic Neisseria. [PDF]
PLoS Pathogens, 2009 Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression).
Yogitha N Srikhanta +13 more
doaj +10 more sources
DNA sequence repeats identify numerous Type I restriction-modification systems that are potential epigenetic regulators controlling phase-variable regulons; phasevarions. [PDF]
FASEB J, 2020 Abstract Over recent years several examples of randomly switching methyltransferases, associated with Type III restriction‐modification (R‐M) systems, have been described in pathogenic bacteria. In every case examined, changes in simple DNA sequence repeats result in variable methyltransferase expression and result in global changes in gene expression,
Atack JM +4 more
europepmc +6 more sources
Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression [PDF]
Nucleic Acids Research, 2007 Phase variably expressed (randomly switching) methyltransferases associated with type III restriction-modification (R-M) systems have been identified in a variety of pathogenic bacteria.
Kate L. Fox +5 more
semanticscholar +8 more sources
ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media [PDF]
The FASEB Journal, 2014 Moraxella catarrhalis is a significant cause of otitis media and exacerbations of chronic obstructive pulmonary disease. Here, we characterize a phase‐variable DNA methyltransferase (ModM), which contains 5′‐CAAC‐3′ repeats in its open reading frame that mediate high‐frequency mutation resulting in reversible on/
Luke V. Blakeway +10 more
semanticscholar +6 more sources