The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development [PDF]
Frontiers in Immunology, 2016 Infectious diseases are a leading cause of morbidity and mortality worldwide, and vaccines are one of the most successful and cost-effective tools for disease prevention.
Aimee Tan +3 more
doaj +4 more sources
Epigenetic Regulation Alters Biofilm Architecture and Composition in Multiple Clinical Isolates of Nontypeable Haemophilus influenzae [PDF]
MBio, 2018 Biofilms play a critical role in the colonization, persistence, and pathogenesis of many human pathogens. Multiple mucosa-associated pathogens have evolved a mechanism of rapid adaptation, termed the phasevarion, which facilitates a coordinated ...
Lauren Bakaletz +2 more
exaly +3 more sources
Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae [PDF]
Infection and Immunity, 2017 Kingella kingae is a common etiological agent of pediatric osteoarticular infections. While current research has expanded our understanding of K. kingae pathogenesis, there is a paucity of knowledge about host-pathogen
Georgina Pollock +2 more
exaly +3 more sources
ModA2 Phasevarion Switching in NontypeableHaemophilus influenzaeIncreases the Severity of Experimental Otitis Media [PDF]
Journal of Infectious Diseases, 2016 Several human-adapted bacterial pathogens use a phasevarion (ie, a phase-variable regulon) to rapidly and reversibly regulate the expression of many genes, which include known virulence factors, yet the influence of phasevarion-mediated regulation in ...
Lauren Bakaletz +2 more
exaly +4 more sources
Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies [PDF]
Trends in Microbiology, 2018 A wide variety of bacterial pathogens express phase-variable DNA methyltransferases that control expression of multiple genes via epigenetic mechanisms.
Lauren Bakaletz +2 more
exaly +3 more sources
Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori [PDF]
Scientific Reports, 2017 The Helicobacter pylori phase variable gene modH, typified by gene HP1522 in strain 26695, encodes a N6-adenosine type III DNA methyltransferase. Our previous studies identified multiple strain-specific modH variants (modH1 – modH19) and showed that ...
Michael P Jennings +2 more
exaly +4 more sources
Phasevarions mediate random switching of gene expression in pathogenic Neisseria. [PDF]
PLoS Pathogens, 2009 Many host-adapted bacterial pathogens contain DNA methyltransferases (mod genes) that are subject to phase-variable expression (high-frequency reversible ON/OFF switching of gene expression).
Yogitha N Srikhanta +13 more
doaj +2 more sources
Broad Conditions Favor the Evolution of Phase-Variable Loci
mBio, 2013 Simple sequence repeat (SSR) tracts produce stochastic on-off switching, or phase variation, in the expression of a panoply of surface molecules in many bacterial commensals and pathogens.
M. E. Palmer +3 more
doaj +3 more sources
DNA sequence repeats identify numerous Type I restriction-modification systems that are potential epigenetic regulators controlling phase-variable regulons; phasevarions. [PDF]
FASEB J, 2020 Abstract Over recent years several examples of randomly switching methyltransferases, associated with Type III restriction‐modification (R‐M) systems, have been described in pathogenic bacteria. In every case examined, changes in simple DNA sequence repeats result in variable methyltransferase expression and result in global changes in gene expression,
Atack JM +4 more
europepmc +2 more sources
Comprehensive Reviews in Food Science and Food Safety, Volume 21, Issue 5, Page 4294-4326, September 2022., 2022 Abstract In complex food systems, bacteria live in heterogeneous microstructures, and the population displays phenotypic heterogeneities at the single‐cell level. This review provides an overview of spatiotemporal drivers of phenotypic heterogeneity of bacterial pathogens in food matrices at three levels.
Cédric Saint Martin +11 more
wiley +1 more source