Results 91 to 100 of about 11,104 (213)
ChemMedChem, Volume 21, Issue 16, 27 August 2026.ST6GAL1 sialylates glycoconjugates in the Golgi, modulating immune recognition and enabling tumor immune evasion. To effectively reach ST6GAL1, inhibitors should demonstrate good membrane permeability. Based on nonpermeable hit JFD 00458, we developed sulfonylurea analogs achieving increased membrane permeability and potency.
Natan Koraj +9 more
wiley +1 more source
Nature Communications, 2016 Some virulent strains of Campylobacter jejuni possess a putative chemotaxis receptor, Tlp11, of unknown function. Here the authors show that Tlp11 specifically interacts with galactose and is required for the chemotaxis response of C. jejunito galactose.
Christopher J. Day +9 more
doaj +1 more source
Viruses, 2018 Arthritogenic alphavirus infections often result in debilitating musculoskeletal disorders that affect the joints, muscle, and bone. In order to evaluate the infection profile of primary human skeletal muscle and chondrocyte cells to Ross River virus ...
Elisa X. Y. Lim +7 more
doaj +1 more source
, 2016 Glycomics is the comprehensive study of glycomes (the entire complement of sugars, whether free or present in more complex molecules of an organism), including genetic, physiologic, pathologic, and other aspects in living organisms.
M. Asif Shahzad +7 more
core +1 more source
GlycoRDF: An ontology to standardize glycomics data in RDF
, 2015 Motivation: Over the last decades several glycomics-based bioinformatics resources and databases have been created and released to the public. Unfortunately, there is no common standard in the representation of the stored information or a common machine ...
Matsubara, Masaaki +12 more
core +2 more sources
Systematic review : glycomics as diagnostic markers for hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the most prevalent primary liver cancer with one of the highest cancer-related mortality rates worldwide.
Meuris, Leander +11 more
core +2 more sources
Frontiers in Oncology, 2019 Aberrant glycosylation is not only a feature of malignant cell transformation, but also plays an important role in metastasis. In the present study, an integrated strategy combining the lectin microarrays and lectin cytochemistry was employed to ...
Hanjie Yu +14 more
doaj +1 more source
, 2022 Glycans expand the structural complexity of proteins by several orders of magnitude, resulting in a tremendous analytical challenge when including them in biomedical research.
Falck, David +24 more
core +1 more source
High-Throughput Analysis and Automation for Glycomics Studies
, 2015 This review covers advances in analytical technologies for high-throughput (HTP) glycomics. Our focus is on structural studies of glycoprotein glycosylation to support biopharmaceutical realization and the discovery of glycan biomarkers for human disease.
Fernandes, D.L. +5 more
core +1 more source
Recent advances in glycoinformatic platforms for glycomics and glycoproteomics
, 2020 Protein glycosylation is the most complex and prevalent post-translation modification in terms of the number of proteins modified and the diversity generated. To understand the functional roles of glycoproteins it is important to gain an insight into the
Abrahams, Jodie L. +6 more
core +1 more source