Results 111 to 120 of about 15,452 (231)

Nine Channel Mid-Power Bipolar Pulse Generator Based on a Field Programmable Gate Array

, 2016
Many channel arbitrary pulse sequence generation is required for the electro-optic reconfiguration of optical waveguide networks in Lithium Niobate. Here we describe a scalable solution to the requirement for mid-power bipolar parallel outputs, based on ...
Fisher, Paul, Haylock, Ben, Kasture, Sachin, Lenzini, Francesco, Lobino, Mirko, Streed, Erik W.   +5 more
core   +1 more source

Numerical modeling of capillary electrophoresis : electrospray mass spectrometry interface design [PDF]

, 2014
Capillary electrophoresis hyphenated with electrospray mass spectrometry (CE-ESI-MS) has emerged in the past decade as one of the most powerful bioanalytical techniques.
Foret, Frantisek, Guttman, András, Jarvas, Gábor   +2 more
core   +1 more source

Global Advances in Hepatocellular Carcinoma Research and Therapy in 2025

Cancer Innovation, Volume 5, Issue 2, April 2026.
This review summarizes key breakthrough advances in hepatocellular carcinoma (HCC) reported in 2025 and presents a multidisciplinary management framework for HCC, integrating early diagnosis, microenvironment insights, and comprehensive therapeutic strategies spanning minimally invasive surgery, locoregional interventions, and systemic pharmacotherapy.
Bo Hu, Qiang Gao
wiley   +1 more source

EUROCarbDB: An open-access platform for glycoinformatics [PDF]

, 2017
The EUROCarbDB project is a design study for a technical framework, which provides sophisticated, freely accessible, open-source informatics tools and databases to support glycobiology and glycomic research. EUROCarbDB is a relational database containing
Blank, Dennis, Campbell, Matthew P., Ceroni, Alessio, Damerell, David R., Dell, Anne, Dwek, Raymond A., Ernst, Beat, Fogh, Rasmus, Frank, Martin, Freire, Ana Ardá, Geyer, Hildegard, Geyer, Rudolf, Harrison, Mathew J., Haslam, Stuart M., Henrick, Kim, Herget, Stefan, Hull, William E., Ionides, John, Joshi, Hiren J., Kamerling, Johannis P., Leeflang, Bas R., Lundborg, Magnus, Lütteke, Thomas, Maass, Kai, Merry, Anthony, Ranzinger, René, Rosen, Jimmy, Royle, Louise, Rudd, Pauline M., Schloissnig, Siegfried, Stenutz, Roland, von der Lieth, Claus-Wilhelm, Vranken, Wim F., Widmalm, Göran   +33 more
core  

Glycomics using mass spectrometry [PDF]

Glycoconjugate Journal, 2012
Mass spectrometry plays an increasingly important role in structural glycomics. This review provides an overview on currently used mass spectrometric approaches such as the characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of proteins and the analysis of glycosphingolipids.
openaire   +3 more sources

Uncovering Immune Niches in Health and Disease Using Spatial Transcriptomics

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Through the lens of spatial transcriptomics and associated tools, novel immune niche constituents can now be resolved. Drawing on gut and tumor contexts, we propose a framework to define immune niches and integrate clonal dynamics, aiming to advance niche‐directed therapies toward precise, context‐specific immune modulation.
Johan Thorsson, Yang Zhao, Eduardo J. Villablanca, Camilla Engblom   +3 more
wiley   +1 more source

Disruption of IL-17-mediated immunosurveillance in the respiratory mucosa results in invasive Streptococcus pyogenes infection

Frontiers in Immunology
IntroductionStreptococcus pyogenes is a Gram-positive pathogen that causes a significant global burden of skin pyoderma and pharyngitis. In some cases, infection can lead to severe invasive streptococcal diseases.
Jamie-Lee Mills, Ailin Lepletier, Victoria Ozberk, Jessica Dooley, Jacqualine Kaden, Ainslie Calcutt, Yongbao Huo, Allan Hicks, Ali Zaid, Michael F. Good, Manisha Pandey   +10 more
doaj   +1 more source

Lipo‐Glc‐1,6‐P2: A Bioprecursor Prodrug for Phosphomannomutase‐2 Congenital Disorder of Glycosylation

IUBMB Life, Volume 78, Issue 4, April 2026.
ABSTRACT Phosphomannomutase‐2 (PMM2) deficiency leads to the prominent Congenital Disorder of Glycosylation (CDG), a rare disease currently lacking effective treatment options. The complete absence of PMM2 activity is incompatible with life, and all patients carry at least one missense destabilising variant that allows residual enzymatic function. This
Federica Sodano, Maria Monticelli, Bruno Hay Mele, Barbara Rolando, Loretta Lazzarato, Angela De Simone, Vincenza Andrisano, Debora Paris, Maria Grazia Rimoli, Maria Vittoria Cubellis, Giuseppina Andreotti   +10 more
wiley   +1 more source

What If Trojan Horse Nanoparticles Could Change the Game for HPV Gene‐Targeted Therapies?

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Human papillomavirus (HPV) is a common sexually transmitted infection linked to various cancers, particularly cervical cancer, primarily driven by high‐risk strains like HPV16 and HPV18. While vaccines are effective in preventing new infections, they do not address existing cases, highlighting the need for innovative therapies.
Trairong Chokwassanasakulkit, Vindya Ranasinghe, Erin Woods, Linh Q. Nguyen, Nigel A. J. McMillan   +4 more
wiley   +1 more source

Pushing Frontiers for Proteoglycans

Proteoglycan Research, Volume 4, Issue 2, April 2026.
ABSTRACT Almost half of proteins have one or more post‐translational glycosylation modifications involving the addition of glycan structures. Proteoglycans are a class of glycosylated proteins with one or more glycosaminoglycan (GAG) chains covalently attached to the core protein.
Marissa L. Maciej‐Hulme
wiley   +1 more source