Results 81 to 90 of about 15,452 (231)

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Glycosylated proteins preserved over millennia: N-glycan analysis of Tyrolean Iceman, Scythian Princess and Warrior. [PDF]

, 2014
An improved understanding of glycosylation will provide new insights into many biological processes. In the analysis of oligosaccharides from biological samples, a strict regime is typically followed to ensure sample integrity.
An, Hyun Joo, Bereuter, Thomas L, Dimapasoc, Lauren, Garrido, Daniel, Grimm, Rudolf, Kim, Bum Jin, Kim, Jae-Han, Lebrilla, Carlito B, Mills, David A, Ozcan, Sureyya, Reiter, Christian, Ro, Grace   +11 more
core   +1 more source

Advancing glycomics: Implementation strategies at the Consortium for Functional Glycomics [PDF]

Glycobiology, 2006
Glycomics-an integrated approach to study structure-function relationships of complex carbohydrates (or glycans)-is an emerging field in this age of post-genomics. Realizing the importance of glycomics, many large scale research initiatives have been established to generate novel resources and technologies to advance glycomics.
Rahul, Raman, Maha, Venkataraman, Subu, Ramakrishnan, Wei, Lang, S, Raguram, Ram, Sasisekharan   +5 more
openaire   +2 more sources

Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances

Mass Spectrometry Reviews, EarlyView.
Abstract With implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation.
Tana V. Palomino, David C. Muddiman
wiley   +1 more source

Analytical and Bioanalytical Chemistry / Determination of true ratios of different N-glycan structures in electrospray ionization mass spectrometry [PDF]

, 2017
Nicht verf\ufcgbarAn ideal method for the analysis of N-glycans would both identify the isomeric structure and deliver a true picture of the relative, if not absolute, amounts of the various structures in one sample.
Altmann, Friedrich, Dalik, Thomas, Gr\ufcnwald-Gruber, Clemens, Maresch, Daniel, Thader, Adreas   +4 more
core   +2 more sources

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Phasevarions in Haemophilus influenzae biogroup aegyptius control expression of multiple proteins

Microbiology Spectrum
Haemophilus influenzae biogroup aegyptius is the causative agent of Brazilian purpuric fever (BPF), an invasive disease with high mortality, that sporadically manifests in children previously suffering conjunctivitis. Though strains of H.
Greg Tram, Freda E.-C. Jen, Zachary N. Phillips, John F. Lancashire, Jamie Timms, Jessica Poole, Michael P. Jennings, John M. Atack   +7 more
doaj   +1 more source

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, EarlyView.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300 [PDF]

, 2016
To characterize the interaction potential of the human vaginal isolate Lactobacillus plantarum CMPG5300, its genome was mined for genes encoding lectin-like proteins.
Balzarini, Jan, Imholz, Nicole CE, Lebeer, Sarah, Liekens, Sandra, Malik, Shweta, Noppen, Sam, Petrova, Mariya I, Schols, Dominique, Van Damme, Els, Vanderleyden, Jos, Verhoeven, Tine LA   +10 more
core   +1 more source

The N‐Glycome to Differentiate Mesenchymal Stem Cells Upon Chondrogenic Differentiation, Dedifferentiation, and Senescence

PROTEOMICS, EarlyView.
ABSTRACT Mesenchymal stem cells (MSCs) are adult stem cells able to self‐renewal or differentiation into different cell types, including chondrocytes. N‐Glycans are post‐translational modifications of glycoproteins that contribute to vital cell functions.
Houda Montacir, Karina Biskup, Michael Sittinger, Rudolf Tauber, Véronique Blanchard   +4 more
wiley   +1 more source