Results 21 to 30 of about 8,738 (176)
The glycointeractome of serogroup B Neisseria meningitidis strain MC58
Scientific Reports, 2017 Neisseria meningitidis express numerous virulence factors that enable it to interact with diverse microenvironments within the host, during both asymptomatic nasopharyngeal colonization and invasive disease.
Tsitsi D. Mubaiwa +7 more
doaj +1 more source
BMC Medicine, 2018 Background The continuing morbidity and mortality associated with infection with malaria parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in clinical trials in malaria-endemic areas has thus far been ...
Danielle I. Stanisic +14 more
doaj +1 more source
The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development
Frontiers in Immunology, 2016 Infectious diseases are a leading cause of morbidity and mortality worldwide, and vaccines are one of the most successful and cost-effective tools for disease prevention.
Aimee Tan +3 more
doaj +1 more source
N-glycolylneuraminic acid as a carbohydrate cancer biomarker
Translational Oncology, 2023 One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). The only known enzyme to biosynthesize Neu5Gc in mammals, cytidine-5′-monophosphate-N-acetylneuraminic acid (CMAH), appears to be ...
Jing Wang +3 more
doaj +1 more source
Advancing glycomics: Implementation strategies at the Consortium for Functional Glycomics [PDF]
Glycobiology, 2006 Glycomics-an integrated approach to study structure-function relationships of complex carbohydrates (or glycans)-is an emerging field in this age of post-genomics. Realizing the importance of glycomics, many large scale research initiatives have been established to generate novel resources and technologies to advance glycomics.
Rahul, Raman +5 more
openaire +2 more sources
Leveraging glycomics data in glycoprotein 3D structure validation with Privateer
Beilstein Journal of Organic Chemistry, 2020 The heterogeneity, mobility and complexity of glycans in glycoproteins have been, and currently remain, significant challenges in structural biology. These aspects present unique problems to the two most prolific techniques: X-ray crystallography and ...
Haroldas Bagdonas +2 more
doaj +1 more source
mBio, 2021 SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.
Christopher J. Day +9 more
doaj +1 more source
Scientific Reports, 2017 Human parainfluenza viruses represent a leading cause of lower respiratory tract disease in children, with currently no available approved drug or vaccine.
Larissa Dirr +4 more
doaj +1 more source
Pneumococcal Phasevarions Control Multiple Virulence Traits, Including Vaccine Candidate Expression
Microbiology Spectrum, 2022 Streptococcus pneumoniae is the most common cause of bacterial illness worldwide. Current vaccines based on the polysaccharide capsule are only effective against a limited number of the >100 capsular serotypes.
Zachary N. Phillips +12 more
doaj +1 more source