Results 11 to 20 of about 11,104 (213)

Marine medicinal glycomics [PDF]

Frontiers in Cellular and Infection Microbiology, 2014
Glycomics is an international initiative aimed to understand the structure and function of the glycans from a given type of cell, tissue, organism, kingdom or even environment, as found under certain conditions.
Vitor Hugo Pomin
doaj   +5 more sources

Glycomics

, 2019
Paramount to our understanding of carbohydrates in biology has been the development of methods for analyzing and characterizing the essential features of glycans.
Struwe, WB, Rudd, PM, Wormald, MR, Kattla, JJ, Cosgrave, EFJ, Campbell, MP   +5 more
core   +4 more sources

Leveraging glycomics data in glycoprotein 3D structure validation with Privateer [PDF]

Beilstein Journal of Organic Chemistry, 2020
The heterogeneity, mobility and complexity of glycans in glycoproteins have been, and currently remain, significant challenges in structural biology. These aspects present unique problems to the two most prolific techniques: X-ray crystallography and ...
Haroldas Bagdonas, Daniel Ungar, Jon Agirre   +2 more
doaj   +2 more sources

Emerging glycomics technologies

Nature Chemical Biology, 2007
The nascent field of glycomics is currently undergoing rapid development, largely as a result of advances in technologies for analyzing glycan structure, unraveling glycan-protein interactions and establishing the functional significance of glycans.
Field, Robert A., Robert A Field, Turnbull, J.E., Turnbull, Jeremy E., Jeremy E Turnbull, Field, R.A.; id_orcid   +5 more
core   +4 more sources

Imaging the glycome [PDF]

Proceedings of the National Academy of Sciences, 2009
Molecular imaging enables visualization of specific molecules in vivo and without substantial perturbation to the target molecule's environment. Glycans are appealing targets for molecular imaging but are inaccessible with conventional approaches.
Scott T, Laughlin, Carolyn R, Bertozzi
openaire   +2 more sources

One Week Exposure to a Somatostatin Receptor 2 Antagonist (SSTR2a) Enhances Glucagon Counterregulation to Insulin-Induced Hypoglycaemia and Does Not Worsen Glycemia in a Male Rat Model of Insulin-Requiring Type 2 Diabetes. [PDF]

Diabetes Obes Metab
ABSTRACT Introduction Administration of a somatostatin receptor 2 antagonist (SSTR2a) increases glucagon responsiveness to hypoglycaemia in insulin‐treated type 2 diabetes (T2D), but the durability of this effect and the impact of repeated SSTR2a dosing on overall glycaemia in T2D are unclear.
D'Souza NC, Hoffman EG, Atherley SC, Champsi S, Aleali N, Liggins RT, Chan O, Riddell MC.   +7 more
europepmc   +2 more sources

Prime-Pull Immunization with a Bivalent M-Protein and Spy-CEP Peptide Vaccine Adjuvanted with CAF®01 Liposomes Induces Both Mucosal and Peripheral Protection from covR/S Mutant Streptococcus pyogenes

mBio, 2021
A vaccine to control S.
Victoria Ozberk, Simone Reynolds, Yongbao Huo, Ainslie Calcutt, Sharareh Eskandari, Jessica Dooley, Jamie-Lee Mills, Ida S. Rasmussen, Jes Dietrich, Manisha Pandey, Michael F. Good   +10 more
doaj   +1 more source

Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection

Parasites & Vectors, 2019
Mosquito-borne diseases are associated with major global health burdens. Aedes spp. and Culex spp. are primarily responsible for the transmission of the most medically important mosquito-borne viruses, including dengue virus, West Nile virus and Zika ...
Wai-Suet Lee, Julie A. Webster, Eugene T. Madzokere, Eloise B. Stephenson, Lara J. Herrero   +4 more
doaj   +1 more source

High-throughput mapping of RNA solvent accessibility at the single-nucleotide resolution by RtcB ligation between a fixed 5′-OH-end linker and unique 3′-P-end fragments from hydroxyl radical cleavage

RNA Biology, 2022
Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights.
Md Solayman, Thomas Litfin, Yaoqi Zhou, Jian Zhan   +3 more
doaj   +1 more source

Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models

mBio, 2023
Mutation within the Streptococcus pyogenes (Streptococcus group A; Strep A) covR/S regulatory system has been associated with a hypervirulent phenotype resulting from the upregulation of several virulence factors, including the pore-forming toxin ...
Emma L. Langshaw, Simone Reynolds, Victoria Ozberk, Jessica Dooley, Ainslie Calcutt, Mehfuz Zaman, Mark J. Walker, Michael R. Batzloff, Mark R. Davies, Michael F. Good, Manisha Pandey   +10 more
doaj   +1 more source