Results 11 to 20 of about 8,797 (182)

Marine medicinal glycomics [PDF]

Frontiers in Cellular and Infection Microbiology, 2014
Glycomics is an international initiative aimed to understand the structure and function of the glycans from a given type of cell, tissue, organism, kingdom or even environment, as found under certain conditions.
Vitor Hugo Pomin
doaj   +3 more sources

Imaging the glycome [PDF]

Proceedings of the National Academy of Sciences, 2009
Molecular imaging enables visualization of specific molecules in vivo and without substantial perturbation to the target molecule's environment. Glycans are appealing targets for molecular imaging but are inaccessible with conventional approaches.
Scott T, Laughlin, Carolyn R, Bertozzi
openaire   +2 more sources

Prime-Pull Immunization with a Bivalent M-Protein and Spy-CEP Peptide Vaccine Adjuvanted with CAF®01 Liposomes Induces Both Mucosal and Peripheral Protection from covR/S Mutant Streptococcus pyogenes

mBio, 2021
A vaccine to control S.
Victoria Ozberk, Simone Reynolds, Yongbao Huo, Ainslie Calcutt, Sharareh Eskandari, Jessica Dooley, Jamie-Lee Mills, Ida S. Rasmussen, Jes Dietrich, Manisha Pandey, Michael F. Good   +10 more
doaj   +1 more source

High-throughput mapping of RNA solvent accessibility at the single-nucleotide resolution by RtcB ligation between a fixed 5′-OH-end linker and unique 3′-P-end fragments from hydroxyl radical cleavage

RNA Biology, 2022
Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights.
Md Solayman, Thomas Litfin, Yaoqi Zhou, Jian Zhan   +3 more
doaj   +1 more source

Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models

mBio, 2023
Mutation within the Streptococcus pyogenes (Streptococcus group A; Strep A) covR/S regulatory system has been associated with a hypervirulent phenotype resulting from the upregulation of several virulence factors, including the pore-forming toxin ...
Emma L. Langshaw, Simone Reynolds, Victoria Ozberk, Jessica Dooley, Ainslie Calcutt, Mehfuz Zaman, Mark J. Walker, Michael R. Batzloff, Mark R. Davies, Michael F. Good, Manisha Pandey   +10 more
doaj   +1 more source

Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection

Parasites & Vectors, 2019
Mosquito-borne diseases are associated with major global health burdens. Aedes spp. and Culex spp. are primarily responsible for the transmission of the most medically important mosquito-borne viruses, including dengue virus, West Nile virus and Zika ...
Wai-Suet Lee, Julie A. Webster, Eugene T. Madzokere, Eloise B. Stephenson, Lara J. Herrero   +4 more
doaj   +1 more source

Streptococcus pyogenes vaccine candidates do not induce autoimmune responses in a rheumatic heart disease model

npj Vaccines, 2023
We have developed a candidate vaccine to protect against multiple strains of Streptococcus pyogenes infections. The candidate vaccine contains two synthetic peptides derived from S. pyogenes proteins: the M-protein epitope, p*17 and the IL-8 degrading S.
Simone Reynolds, Rukshan Ahamed Mohamed Rafeek, Adam Hamlin, Ailin Lepletier, Manisha Pandey, Natkunam Ketheesan, Michael F. Good   +6 more
doaj   +1 more source

The glycointeractome of serogroup B Neisseria meningitidis strain MC58

Scientific Reports, 2017
Neisseria meningitidis express numerous virulence factors that enable it to interact with diverse microenvironments within the host, during both asymptomatic nasopharyngeal colonization and invasive disease.
Tsitsi D. Mubaiwa, Lauren E. Hartley-Tassell, Evgeny A. Semchenko, Freda. E.-C. Jen, Yogitha N. Srikhanta, Christopher J. Day, Michael P. Jennings, Kate L. Seib   +7 more
doaj   +1 more source

Vaccination with chemically attenuated Plasmodium falciparum asexual blood-stage parasites induces parasite-specific cellular immune responses in malaria-naïve volunteers: a pilot study

BMC Medicine, 2018
Background The continuing morbidity and mortality associated with infection with malaria parasites highlights the urgent need for a vaccine. The efficacy of sub-unit vaccines tested in clinical trials in malaria-endemic areas has thus far been ...
Danielle I. Stanisic, James Fink, Johanna Mayer, Sarah Coghill, Letitia Gore, Xue Q. Liu, Ibrahim El-Deeb, Ingrid B. Rodriguez, Jessica Powell, Nicole M. Willemsen, Sai Lata De, Mei-Fong Ho, Stephen L. Hoffman, John Gerrard, Michael F. Good   +14 more
doaj   +1 more source

N-glycolylneuraminic acid as a carbohydrate cancer biomarker

Translational Oncology, 2023
One of the forms of aberrant glycosylation in human tumors is the expression of N-glycolylneuraminic acid (Neu5Gc). The only known enzyme to biosynthesize Neu5Gc in mammals, cytidine-5′-monophosphate-N-acetylneuraminic acid (CMAH), appears to be ...
Jing Wang, Lucy K. Shewell, Christopher J. Day, Michael P. Jennings   +3 more
doaj   +1 more source