Results 11 to 20 of about 8,738 (176)

Preclinical safety and immunogenicity of Streptococcus pyogenes (Strep A) peptide vaccines

Scientific Reports, 2021
We have developed two candidate vaccines to protect against multiple strains of Strep A infections. The candidates are combinatorial synthetic peptide vaccines composed of a M protein epitope (J8 or p*17) and a non-M protein epitope (K4S2).
Simone Reynolds, Manisha Pandey, Jessica Dooley, Ainslie Calcutt, Michael Batzloff, Victoria Ozberk, Jamie-Lee Mills, Michael Good   +7 more
doaj   +1 more source

Introduction to a special issue, “Expanded glycomics: A bridge over future glycomics” [PDF]

BBA Advances
Jun Hirabayashi, Yann Guerardel
doaj   +2 more sources

Discovery of Cofactor Competitive Inhibitors against the Human Methyltransferase Fibrillarin

Pharmaceuticals, 2021
Fibrillarin (FBL) is an essential and evolutionarily highly conserved S-adenosyl methionine (SAM) dependent methyltransferase. It is the catalytic component of a multiprotein complex that facilitates 2′-O-methylation of ribosomal RNAs (rRNAs), a ...
Yun Shi, Ibrahim M. El-Deeb, Veronika Masic, Lauren Hartley-Tassell, Andrea Maggioni, Mark von Itzstein, Thomas Ve   +6 more
doaj   +1 more source

A CAF01-adjuvanted whole asexual blood-stage liposomal malaria vaccine induces a CD4+ T-cell-dependent strain-transcending protective immunity in rodent models

mBio, 2023
Malaria is a leading cause of illness and death in children under 5 years of age in Sub-Saharan Africa. Currently, there is no highly efficacious malaria vaccine capable of inducing long-lasting immunity.
Winter A. Okoth, Mei-Fong Ho, Mehfuz Zaman, Emily Cooper, Priyanka Som, Mark Burgess, Maddison Walton, Reshma J. Nevagi, Lynette Beattie, Declan Murphy, Danielle I. Stanisic, Michael F. Good   +11 more
doaj   +1 more source

New Perspectives on Escherichia coli Signal Peptidase I Substrate Specificity: Investigating Why the TasA Cleavage Site Is Incompatible with LepB Cleavage

Microbiology Spectrum, 2023
Escherichia coli signal peptidase I (LepB) has been shown to inefficiently cleave secreted proteins with aromatic amino acids at the second position after the signal peptidase cleavage site (P2′).
Joanna E. Musik, Jessica Poole, Christopher J. Day, Thomas Haselhorst, Freda E.-C. Jen, Thomas Ve, Veronika Masic, Michael P. Jennings, Yaramah M. Zalucki   +8 more
doaj   +1 more source

Prime-Pull Immunization with a Bivalent M-Protein and Spy-CEP Peptide Vaccine Adjuvanted with CAF®01 Liposomes Induces Both Mucosal and Peripheral Protection from covR/S Mutant Streptococcus pyogenes

mBio, 2021
A vaccine to control S.
Victoria Ozberk, Simone Reynolds, Yongbao Huo, Ainslie Calcutt, Sharareh Eskandari, Jessica Dooley, Jamie-Lee Mills, Ida S. Rasmussen, Jes Dietrich, Manisha Pandey, Michael F. Good   +10 more
doaj   +1 more source

High-throughput mapping of RNA solvent accessibility at the single-nucleotide resolution by RtcB ligation between a fixed 5′-OH-end linker and unique 3′-P-end fragments from hydroxyl radical cleavage

RNA Biology, 2022
Given the challenges for the experimental determination of RNA tertiary structures, probing solvent accessibility has become increasingly important to gain functional insights.
Md Solayman, Thomas Litfin, Yaoqi Zhou, Jian Zhan   +3 more
doaj   +1 more source

Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models

mBio, 2023
Mutation within the Streptococcus pyogenes (Streptococcus group A; Strep A) covR/S regulatory system has been associated with a hypervirulent phenotype resulting from the upregulation of several virulence factors, including the pore-forming toxin ...
Emma L. Langshaw, Simone Reynolds, Victoria Ozberk, Jessica Dooley, Ainslie Calcutt, Mehfuz Zaman, Mark J. Walker, Michael R. Batzloff, Mark R. Davies, Michael F. Good, Manisha Pandey   +10 more
doaj   +1 more source

Streptococcus pyogenes vaccine candidates do not induce autoimmune responses in a rheumatic heart disease model

npj Vaccines, 2023
We have developed a candidate vaccine to protect against multiple strains of Streptococcus pyogenes infections. The candidate vaccine contains two synthetic peptides derived from S. pyogenes proteins: the M-protein epitope, p*17 and the IL-8 degrading S.
Simone Reynolds, Rukshan Ahamed Mohamed Rafeek, Adam Hamlin, Ailin Lepletier, Manisha Pandey, Natkunam Ketheesan, Michael F. Good   +6 more
doaj   +1 more source

Mosquito antiviral defense mechanisms: a delicate balance between innate immunity and persistent viral infection

Parasites & Vectors, 2019
Mosquito-borne diseases are associated with major global health burdens. Aedes spp. and Culex spp. are primarily responsible for the transmission of the most medically important mosquito-borne viruses, including dengue virus, West Nile virus and Zika ...
Wai-Suet Lee, Julie A. Webster, Eugene T. Madzokere, Eloise B. Stephenson, Lara J. Herrero   +4 more
doaj   +1 more source