Results 301 to 310 of about 145,105 (353)

Glycoproteomics of Gastrointestinal Cancers and Its Use in Clinical Diagnostics. [PDF]

J Proteome Res
Bertok T, Pinkeova A, Lorencova L, Datkova A, Hires M, Jane E, Tkac J.   +6 more
europepmc   +1 more source

Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange

Aging Cell, EarlyView.
Therapeutic plasma exchange safely reduces biological age by up to 2.6 years. Multi‐omics analysis reveals coordinated cellular and molecular responses associated with aging rejuvenation. ABSTRACT We conducted a randomized, placebo‐controlled trial to assess the safety and biological age (BA) effects of various therapeutic plasma exchange (TPE ...
Matias Fuentealba, Dobri Kiprov, Kevin Schneider, Wei‐Chieh Mu, Prasanna Ashok Kumaar, Herbert Kasler, Jordan B. Burton, Mark Watson, Heather Halaweh, Christina D. King, Zehra Stara Yüksel, Chelo Roska‐Pamaong, Birgit Schilling, Eric Verdin, David Furman   +14 more
wiley   +1 more source

Multiplexed glycan immunofluorescence identification of pancreatic cancer cell subpopulations in both tumor and blood samples. [PDF]

Sci Adv
Binkowski B, Klamer Z, Gao C, Staal B, Repesh A, Tran HL, Brass DM, Bartlett P, Gallinger S, Blomqvist M, Morrow JB, Allen P, Shi C, Singhi A, Brand R, Huang Y, Hostetter G, Haab BB.   +17 more
europepmc   +1 more source

Vaccine‐Induced Anti‐IgE Antibodies Neutralize Free IgE but Fail to Bind and Activate Mast Cell‐Displayed IgE

Allergy, EarlyView.
We investigated the mechanisms by which a previously established VLP‐based anti‐IgE vaccine protects against allergic anaphylaxis. We show that passively administered vaccine‐induced IgGs into allergic mice protects them from anaphylaxis without side effects.
Zahra Gharailoo, Monique Vogel, Paul Engeroff, Martin F. Bachmann   +3 more
wiley   +1 more source

Expedient Assembly of Multiantennary <i>N</i>-Glycans from Common <i>N</i>-Glycan Cores with Orthogonal Protection for the Profiling of Glycan-Binding Proteins. [PDF]

J Am Chem Soc
Li R, Chen P, Zeng YF, Tseng TH, Gannedi V, Krasnova L, Wong CH.   +6 more
europepmc   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Utilizing non-clonal CHO cell derived materials for preclinical studies of complex molecules. [PDF]

BMC Biotechnol
Pan J, McPhee J, Dow A, Burke D, Gupta B, Rose P, Wang X, Pinto N, Letarte S, Huang Y, Li GB, Agarwal K, Smith K, Liu R.   +13 more
europepmc   +1 more source

High‐throughput screen identifies MAS9 as a novel inhibitor of the C‐type lectin receptor‐2 (CLEC‐2)–podoplanin interaction

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa, Yan Wu, Jan van Groningen, Ying Di, Helma van den Hurk, Johannes A. Eble, Jonathan M. Gibbins, Ángel García, Alice Y. Pollitt   +8 more
wiley   +1 more source

Novel Endo-β-<i>N</i>-Acetylglucosaminidases Derived from Human Fecal Samples Selectively Release <i>N</i>-Glycans from Model Glycoproteins. [PDF]

Foods
Bolino M, Haththotuwe Gamage N, Duman H, Abiodun O, De Mello AS, Karav S, Frese SA.   +6 more
europepmc   +1 more source