Results 121 to 130 of about 88,542 (309)
Glycans of plasma ADAMTS13 [PDF]
Blood, 2016 In this issue of Blood , [Verbij et al][1] identified the sites of glycosylation in plasma ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) and determined the composition of the glycan structures at these sites.[1][2] ADAMTS13 is a blood enzyme ...
openaire +2 more sources
Advanced Science, EarlyView.Genome‐wide CRISPRi and RNA‐seq resolve how B. thetaiotaomicron converts host mucosal glycans into fitness. The study reveals a layered mucin‐utilization architecture in which capsular polysaccharides constrain surface access, extracellular CAZymes and peptidases show functional redundancy, and intracellular catabolic pathways create discrete metabolic
Kangsan Kim +5 more
wiley +1 more source
General Microarray Technique for Immobilization and Screening of Natural Glycans
, 2016 We here present a printed covalent glycan microarray for protein-binding studies, using low-femtomole quantities of glycans. Glycans, either natural glycans, which were released from glycoproteins and glycolipids from natural sources, or synthetic ...
Manfred Wuhrer (200842) +3 more
core +1 more source
Advanced Science, EarlyView.Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana +19 more
wiley +1 more source
The Nature of Cell‐Penetrating Poly(disulfide)s
Angewandte Chemie, EarlyView.The mode of action of cell‐penetrating poly(disulfide)s (CPDs) is elucidated to understand thiol‐mediated uptake (TMU) in general and guide future efforts to control cellular entry for chemicals delivery and pathogen defense. ABSTRACT Cell‐penetrating poly(disulfide)s (CPDs) are the most popular thiol‐mediated uptake (TMU) tools for delivering attached
Saidbakhrom Saidjalolov +7 more
wiley +2 more sources
The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function
Frontiers in Immunology, 2019 Among responders to microbial invasion, neutrophils represent one of the earliest and perhaps most important factors that contribute to initial host defense.
Brian S. Robinson +10 more
doaj +1 more source
Advanced Science, EarlyView.Secreted glycoproteins report on cellular state faster than the cell surface, yet remain hard to measure. The Enzyme‐Linked Cycloaddition Assay (ELCA) combines metabolic azide labeling with click chemistry in an ELISA‐like microplate format, resolving sialylation changes within minutes for 1‐2 EUR per sample.
Jon Lundstrøm +2 more
wiley +1 more source
Angewandte Chemie, EarlyView.A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu +7 more
wiley +2 more sources
Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming
Advanced Science, EarlyView.Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva +18 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.M2BPGi reflects background liver fibrosis and hepatic functional impairment. PET SUVmax reflects tumor metabolic aggressiveness. Their combination identifies a dual‐high subgroup with the poorest recurrence‐free and overall survival. ABSTRACT Aim To evaluate the prognostic significance of preoperative Mac‐2 binding protein glycosylation isomer (M2BPGi)
Kojiro Shirabe +8 more
wiley +1 more source