Results 101 to 110 of about 88,542 (309)

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

The Role of Sialidases in the Development of Bacterial Vaginosis and their Use as Potential Markers in the Diagnosis of Vaginal Infections

Postępy Mikrobiologii
Bacterial vaginosis (BV) is an inflammatory condition of the vagina with a polyetiological origin, most commonly associated with an overgrowth of anaerobic bacteria such as Gardnerella vaginalis or Prevotella spp.
Bodaszewska-Lubaś Małgorzata, Kot Karolina, Brzychczy-Włoch Monika   +2 more
doaj   +1 more source

Enhanced sensitive MS analysis of sulfated glycans [PDF]

, 2014
Sulfated glycans widely exist in cells and tissues of human body. They are involved in many biological activities such as protein folding and degradation, cell growth, cell-cell interaction, and anticoagulation.
Yang, Tianjiao
core  

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Bacterial growth on sialylated glycans.

, 2014
Bacterial growth on sialylated glycans.
Carsten Jers (356447), Dorte M. Larsen (505582), Haiying Li (164527), Anne S. Meyer (505585), Kasper P. Kepp (386868), Yao Guo (505583), Finn Kirpekar (505584), Jørn D. Mikkelsen (505586), Malwina Michalak (505581)   +8 more
core   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Complex N-glycans are essential, but core 1 and 2 mucin O-glycans, O-fucose glycans, and NOTCH1 are dispensable, for mammalian spermatogenesis.

, 2016
To identify roles in spermatogenesis for major subclasses of N- and O-glycans and Notch signaling, male mice carrying floxed C1galt1, Pofut1, Notch1 or Mgat1 alleles and a testis-specific Cre recombinase transgene were generated.

core   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Intracellular Delivery of Hydrophilic Glycans Using Superchaotropic Clusters [PDF]

The intracellular delivery of glycans is a significant challenge. Glycan delivery is typically achieved by per‐acetylation necessitating the use of the cytotoxic carrier solvent DMSO, or complex nanoscale delivery devices, to transit across the cell ...
Qiao Tang, Alexandru Ilie, Matthew I. Gibson   +2 more
core   +2 more sources

Role of glycans in cancer cells undergoing epithelial-mesenchymal transition [PDF]

, 2016
The term cancer refers to a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Epithelial-mesenchymal transition (EMT), a process whereby epithelial cells lose their cell polarity and cell ...
Zengqi eTan, Xin Wang, Feng Guan, Zengqi Tan, Si eChen, Xiang eLi, Xin eWang, Feng eGuan, Xiang Li, Si Chen   +9 more
core   +1 more source