Results 91 to 100 of about 86,469 (209)

8-plex LC-MS/MS Analysis of Permethylated N-glycans Achieved by Using Stable Isotopic Iodomethane

, 2019
Glycosylation is an important post-translational modification of proteins. Many diseases, such as cancer have proved to be related to aberrant glycosylation.
Tang, Haixu, Yu, Chuan-Yih, Mechref, Yehia, Dong, Xue, Zhou, Shiyue, Peng, Wenjing, Donohoo, Kaitlyn B.   +6 more
core  

All major cholesterol-dependent cytolysins use glycans as cellular receptors

, 2020
Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism.
Brouwer, Stephan, Kobe, Bostjan, Gillen, Christine M, Reijneveld, Josephine F, James, David B. A., Paton, James C., Luo, Zhenyao, Atack, John M, Walker, Mark J., Day, Christopher J, Gillen, Christine M., Atack, John M., Day, Christopher J., Shewell, Lucy K., Haselhorst, Thomas, Reijneveld, Josephine F., Boguslawski, Kristina M., von Itzstein, Mark, Jennings, Michael P, Everest-Dass, Arun, Jen, Freda E.-C., Paton, Adrienne W., Torres, Victor J., Jen, Freda E-C, Boguslawski, Kristina M, Jennings, Michael P., Nizet, Victor, Shewell, Lucy K, James, David BA, et al.   +29 more
core   +1 more source

Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

eLife
The spike protein is essential to the SARS-CoV-2 virus life cycle, facilitating virus entry and mediating viral-host membrane fusion. The spike contains a fatty acid (FA) binding site between every two neighbouring receptor-binding domains.
A Sofia F Oliveira, Fiona L Kearns, Mia A Rosenfeld, Lorenzo Casalino, Lorenzo Tulli, Imre Berger, Christiane Schaffitzel, Andrew D Davidson, Rommie E Amaro, Adrian J Mulholland   +9 more
doaj   +1 more source

Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8

Journal of Extracellular Vesicles, 2018
Cancer cells release extracellular vesicles (EVs) that contain functional biomolecules such as RNA and proteins. EVs are transferred to recipient cancer cells and can promote tumour progression and therapy resistance.
Jordi Berenguer, Tonny Lagerweij, Xi Wen Zhao, Sophie Dusoswa, Petra van der Stoop, Bart Westerman, Mark C. de Gooijer, Marloes Zoetemelk, Anoek Zomer, Matheus H. W. Crommentuijn, Laurine E. Wedekind, Àlan López-López, Alberta Giovanazzi, Marina Bruch-Oms, Ida H. van der Meulen-Muileman, Rogier M. Reijmers, Toin H. van Kuppevelt, Juan-Jesús García-Vallejo, Yvette van Kooyk, Bakhos A. Tannous, Pieter Wesseling, Danijela Koppers-Lalic, W. Peter Vandertop, David P. Noske, Victor W. van Beusechem, Jacco van Rheenen, D. Michiel Pegtel, Olaf van Tellingen, Thomas Wurdinger   +28 more
doaj   +1 more source

The Role of Glycans in Human Immunity—A Sweet Code

Molecules
Glycans on the surface of all immune cells are the product of diverse post-translational modifications (glycosylation) that affect almost all proteins and possess enormous structural heterogeneity.
Igor Tvaroška
doaj   +1 more source

Leveraging Glycan–Glycan Interactions to Tune the Conformation of Glycan Hairpins and Build Rigid 3D Architectures

Journal of the American Chemical Society
Glycan folding and aggregation remain poorly understood despite their essential roles in structural and biological functions. We present a reductionist approach leveraging a glycan sequence that spontaneously folds into a hairpin conformation, enabling the systematic analysis of glycan intra- and intermolecular interactions.
Nishu Yadav, Yadiel Vázquez-Mena, Ana Poveda, Dominik Weh, Jesús Jiménez-Barbero, Yu Ogawa, Martina Delbianco   +6 more
openaire   +2 more sources

Streamlined gram-scale natural N-glycan production using reversible tagging after oxidative release of natural glycans

Communications Chemistry
The study of natural glycans is fundamental to modern glycomics; however, the functional analysis of these glycans is limited by their low natural abundance, structural heterogeneity, and the absence of efficient preparative-scale isolation methods. Here,
Qing Zhang, Yi Lasanajak, Menxin Yan, Golden Chen, Xuezheng Song   +4 more
doaj   +1 more source

Relationship of N-glycans to Neuronal Dysfunction

, 2019
N-glycosylation is important in regulating protein activity and serves several vital roles contributing to protein folding, protein assembly, stability, and interactions.
Whitman, Austin A
core   +2 more sources

Profiling of N-linked Glycans from Human Serum with Oxidative Ordered Mesoporous Carbon

, 2009
Glycosylation is one of the most common forms of post-translational modifications on proteins, and glycoproteins account more than 50% in eukaryotic proteins.
秦洪强, 吴仁安, 邹汉法, 潘陈松, 陈锐, 赵梁   +5 more
core  

Chemical Methods for Imaging Glycans during Development [PDF]

, 2011
Glycans are carbohydrate structures that cover the surfaces of all cells and mediate cell-cell interactions essential for the functioning of multicellular organisms.
Dehnert, Karen Worthington
core