Results 71 to 80 of about 116,660 (304)
First Step Towards Glycan Modeling: Charmm-Gui Glycan Reader and Glycan Database [PDF]
Biophysical Journal, 2011 Glycosylation is an important post-translational modification of proteins. Considerable efforts have been made to understand how glycosylation affects the structure, dynamics and function of proteins, yet, in general terms, it remains an unsolved questions due to the diversity and variability in the glycosylation.
Jo, Sunhwan +3 more
openaire +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Frontiers in NanotechnologySurface coatings with polyethylene glycol (PEG) polymers have often been employed to improve nanoparticles (NPs) biocompatibility and extend circulation time by reducing protein adsorption.
Eva Clemente +9 more
doaj +1 more source
Preparation of Complex Glycans From Natural Sources for Functional Study
Frontiers in Chemistry, 2020 One major barrier in glycoscience is the lack of diverse and biomedically relevant complex glycans in sufficient quantities for functional study. Complex glycans from natural sources serve as an important source of these glycans and an alternative to ...
Qing Zhang, Zhonghua Li, Xuezheng Song
doaj +1 more source
Biology, 2021 Neurological difficulties commonly accompany individuals suffering from congenital disorders of glycosylation, resulting from defects in the N-glycosylation pathway.
Fadi A. Issa +5 more
doaj +1 more source
Glycoform Modification of Secreted Recombinant Glycoproteins through Kifunensine Addition during Transient Vacuum Agroinfiltration. [PDF]
, 2018 Kifunensine, a potent and selective inhibitor of class I α-mannosidases, prevents α-mannosidases I from trimming mannose residues on glycoproteins, thus resulting in oligomannose-type glycans.
Kailemia, Muchena J +5 more
core +3 more sources
Fluorescent Glycan Derivatives: Their Use for Natural Glycan Microarrays [PDF]
ACS Chemical Biology, 2009 Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on surfaces.
Sungjin, Park +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Discovery of Serotransferrin Glycoforms: Novel Markers for Diagnosis of Liver Periductal Fibrosis and Prediction of Cholangiocarcinoma. [PDF]
, 2019 Cholangiocarcinoma (CCA) caused by chronic liver fluke infection is a major public health problem in Northeast Thailand. Identification of CCA risk groups is urgently needed for the control of CCA in this region.
Barboza, Mariana +10 more
core +2 more sources
Advanced Functional Materials, EarlyView.This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian +5 more
wiley +1 more source