Results 51 to 60 of about 86,469 (209)

Ion-Mobility Mass Spectrometry of Glycans and Glycopeptides Using Both Intact and Glycan Sequencing Approaches In Positive Ion Mode Facilitates Glycan Isomer and Glycan Motif Identification [PDF]

, 2020
High resolution glycan analysis has become an important part of biopharmaceutical API production and quality control. Liquid chromatography (LC) is now a well-established technique in this field but the resolution of similar isomeric glycan structures is
Sabine, Flitsch, jien nee, tai, Edward, Pallister, Yuansheng, Yang, Say-Kong, Ng, Pauline, Rudd, Shi-Jie, Tay, ian, walsh, Matthew, Choo, Terry, Nguyen-Khuong   +9 more
core   +2 more sources

The cell surface protein MUL_3720 confers binding of the skin pathogen Mycobacterium ulcerans to sulfated glycans and keratin. [PDF]

, 2021
Mycobacterium ulcerans is the causative agent of the chronic, necrotizing skin disease Buruli ulcer. Modes of transmission and molecular mechanisms involved in the establishment of M. ulcerans infections are poorly understood.
Pluschke, G., Gerd Pluschke, Röltgen, K., Jennings, M. P., Day, C. J., Röltgen, Katharina, Jennings, Michael P, Katharina Röltgen, Michael P Jennings, Christopher J Day, Day, Christopher J, Pluschke, Gerd   +11 more
core   +1 more source

Determining the Importance of Carbohydrate-Based Structures in Murine Norovirus Binding to Commensal Bacteria

Viruses
Norovirus–bacterial interactions influence viral replication and immune responses, yet the molecular details that mediate binding of these viruses to commensal bacteria are unknown.
Jasmine L. Madrigal, Joseph P. Sullivan, Feba Mathew, Melanie Bland, Melissa K. Jones   +4 more
doaj   +1 more source

Synthesis and Antibody Binding Studies of Schistosome-Derived Oligo-α-(1-2)-l-Fucosides

Molecules, 2021
Schistosomiasis is caused by blood-dwelling parasitic trematodes of the genus Schistosoma and is classified by the WHO as the second most socioeconomically devastating parasitic disease, second only to malaria.
Michael R. Harvey, Fabrizio Chiodo, Wouter Noest, Cornelis H. Hokke, Gijsbert A. van der Marel, Jeroen D.C. Codée   +5 more
doaj   +1 more source

Fragments of bacterial endoglycosidase S and immunoglobulin G reveal subdomains of each that contribute to deglycosylation [PDF]

, 2014
Endoglycosidase S (EndoS) is a glycoside-hydrolase secreted by the bacterium Streptococcus pyogenes. EndoS preferentially hydrolyzes the N-linked glycans from the Fc region of IgG during infection. This hydrolysis impedes Fc functionality and contributes
Yu, Xiaojie, Crispin, Max, Vesiljevic, Snezana, Pritchard, Laura K., Mattick, Susan, Scanlan, Christopher N., Baruah, Kavitha, Schnell, Jason R., Higgins, Matthew K., Krishna, Benjamin, Harvey, David J., Dixon, Emma V., Claridge, Jolyon K., Zitzmann, Nicole   +13 more
core   +1 more source

Evaluating the Pathogenic Potential of IgE Targeting Cross-Reactive Carbohydrate Determinants in Dogs

Animals
Cross-reactive carbohydrate determinants (CCDs) are complex N-glycans shared among allergens of plant, insect venom, and nematode origin. In allergic humans, IgE anti-CCD often develop and cause discrepancies between serological and skin tests.
Thierry Olivry, Ana Mas Fontao, Laura Widorn, Ralf S. Mueller   +3 more
doaj   +1 more source

Compromised N-Glycosylation Processing of Kv3.1b Correlates with Perturbed Motor Neuron Structure and Locomotor Activity

Biology, 2021
Neurological difficulties commonly accompany individuals suffering from congenital disorders of glycosylation, resulting from defects in the N-glycosylation pathway.
Fadi A. Issa, M. Kristen Hall, Cody J. Hatchett, Douglas A. Weidner, Alexandria C. Fiorenza, Ruth A. Schwalbe   +5 more
doaj   +1 more source

FUT8 Is a Critical Driver of Prostate Tumour Growth and Can Be Targeted Using Fucosylation Inhibitors

Cancer Medicine
Background An unmet clinical need requires the discovery of new treatments for men facing advanced prostate cancer. Aberrant glycosylation is a universal feature of cancer cells and plays a key role in tumour growth, immune evasion and metastasis ...
Kayla Bastian, Margarita Orozco‐Moreno, Huw Thomas, Kirsty Hodgson, Eline A. Visser, Emiel Rossing, Johan F. A. Pijnenborg, Nienke Eerden, Laura Wilson, Hasvini Saravannan, Oliver Hanley, Grace Grimsley, Fiona Frame, Ziqian Peng, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Norman J. Maitland, Rakesh Heer, Ning Wang, Ethan D. Goddard‐Borger, Ramon Hurtado Guerrero, Thomas J. Boltje, Richard R. Drake, Emma Scott, David J. Elliott, Jennifer Munkley   +28 more
doaj   +1 more source

The forecasting power of the mucin-microbiome interplay in livestock respiratory diseases

Veterinary Quarterly
Complex respiratory diseases are a significant challenge for the livestock industry worldwide. These diseases considerably impact animal health and welfare and cause severe economic losses.
Núria Mach
doaj   +1 more source

Clickable Galactose Analogs for Imaging Glycans in Developing Zebrafish [PDF]

, 2019
Galactose is one of only nine monosaccharide precursors used to build complex glycans in vertebrates. Defects in galactose metabolism cause galactosemia and lysosomal storage diseases, and the ability to visualize metabolic flux through these pathways ...
Wendy, Cao, Jeremy, Baskin, Johnny, Ye, Jessica, Daughtry   +3 more
core   +2 more sources