Results 51 to 60 of about 116,660 (304)

Sialylated and sulfated N-Glycans in MDCK and engineered MDCK cells for influenza virus studies

Scientific Reports, 2022
The Madin-Darby canine kidney (MDCK) cell line is an in vitro model for influenza A virus (IAV) infection and propagation. MDCK-SIAT1 (SIAT1) and humanized MDCK (hCK) cell lines are engineered MDCK cells that express N-glycans with elevated levels of ...
Lauren Byrd-Leotis, Nan Jia, Yasuyuki Matsumoto, Dongli Lu, Yoshihiro Kawaoka, David A. Steinhauer, Richard D. Cummings   +6 more
doaj   +1 more source

Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins [PDF]

, 2019
Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the
Adamczyk, Barbara, Chahal, Gurdeep, Ducatelle, Richard, Erhardsson, Mattias, Flahou, Bram, Haesebrouck, Freddy, Jin, Chunsheng, Karlsson, Niclas G, Linden, Sara K, Padra, Medea, Smet, Annemieke, Thorell, Anders   +11 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization [PDF]

, 2019
Author summary The intestinal epithelium is a crucial biological interface, interacting with both commensal and pathogenic microorganisms. It’s lined with heavily glycosylated proteins and glycolipids which can act as both attachment sites and energy ...
Baines, J., Boyle, E., Casadesús, J., Gal-Mor, O., Galeev, A., García Pastor, L., Grassl, G., Hensel, M., Riedel, R., Seeger, K., Sharma, S., Sterzenbach, T., Suwandi, A.   +12 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Three semi-synthetic approaches to a set of curdlan sulfate polysaccharides with different sulfation patterns

Frontiers in Molecular Biosciences
IntroductionCurdlan is a linear homopolysaccharide composed of β-1→3-linked glucose units. It is extracted from some bacteria as an exopolysaccharide and employed in the food industry due to its remarkable rheological and thermal behaviors.
Fabiana Esposito, Agnieszka Zabłocka, Serena Traboni, Alfonso Iadonisi, Sabina Górska, Emiliano Bedini   +5 more
doaj   +1 more source

Impact of structurally diverse polysaccharides on colonic mucin O-glycosylation and gut microbiota

npj Biofilms and Microbiomes, 2023
Understanding how dietary polysaccharides affect mucin O-glycosylation and gut microbiota could provide various nutrition-based treatments. Here, the O-glycan profile of the colonic mucosa and gut microbiome were investigated in C57BL/6J mice fed six ...
Tong Zhao, Yue Zhang, Linhua Nan, Qing Zhu, Shukai Wang, Yutao Xie, Xinling Dong, Cui Cao, Xiaoliang Lin, Yu Lu, Yuxia Liu, Linjuan Huang, Guiping Gong, Zhongfu Wang   +13 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Determining the Importance of Carbohydrate-Based Structures in Murine Norovirus Binding to Commensal Bacteria

Viruses
Norovirus–bacterial interactions influence viral replication and immune responses, yet the molecular details that mediate binding of these viruses to commensal bacteria are unknown.
Jasmine L. Madrigal, Joseph P. Sullivan, Feba Mathew, Melanie Bland, Melissa K. Jones   +4 more
doaj   +1 more source

Analysis of Schistosoma mansoni Extracellular Vesicles Surface Glycans Reveals Potential Immune Evasion Mechanism and New Insights on Their Origins of Biogenesis

Pathogens, 2021
Parasitic helminths are master manipulators of host immunity. Their strategy is complex and involves the release of excreted/secreted products, including extracellular vesicles (EVs). The protein and miRNA contents of EVs have been characterised for many
Maude Dagenais, Jared Q. Gerlach, George R. Wendt, James J. Collins, Louise E. Atkinson, Angela Mousley, Timothy G. Geary, Thavy Long   +7 more
doaj   +1 more source