Results 31 to 40 of about 116,660 (304)

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Frontiers in Microbiology, 2022
Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines. The extensively glycosylated
Soledad Stagnoli, Francesca Peccati, Sean R. Connell, Sean R. Connell, Sean R. Connell, Ane Martinez-Castillo, Diego Charro, Oscar Millet, Chiara Bruzzone, Asis Palazon, Asis Palazon, Ana Ardá, Ana Ardá, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, June Ereño-Orbea, June Ereño-Orbea, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Gonzalo Jiménez-Osés, Gonzalo Jiménez-Osés   +21 more
doaj   +1 more source

Identification and functional characterization of a highly divergent N-acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei [PDF]

, 2014
Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans.
Acosta-Serrano, Angela Mehlert, Atrih, Bangs, Bangs, Bendiak, Chang, Cross, Cross, Cross, Di Wu, Doering, Ferguson, Ferguson, Giraudo, Grab, Güther, Harpaz, Ho, Hwa, Ioffe, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Izquierdo, Joao A. Rodrigues, Jones, Kornfeld, Leal, Lombard, M.Lucia S. Güther, Manthri, Manuela Damerow, Mazhari-Tabrizi, Mehlert, Mehlert, Mehlert, Mehlert, Mehlert, Metzler, Michael A.J. Ferguson, Milne, Nagamune, Narimatsu, Nolan, Paschinger, Paulson, Pays, Rovis, Schachter, Sonnhammer, Tabas, Tazeh, Urbaniak, Vella, Visser, Wiggins, Wirtz, Wiśniewski, Zamze   +60 more
core   +3 more sources

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding [PDF]

, 2016
The surface envelope glycoprotein (SU) of Human immunodeficiency virus type 1 (HIV-1), gp120SU plays an essential role in virus binding to target CD4+ T-cells and is a major vaccine target.
Bess, JW, Binet, D, Bouché, L, Canis, K, Chertova, E, Dell, A, Desrosiers, RC, Haslam, SM, Keele, BF, Lifson, JD, Morris, HR, North, SJ, O'Connor, MJ, Pang, PC, Panico, M, Rahman, D   +15 more
core   +1 more source

Profiling of Glycan Receptors for Minute Virus of Mice in Permissive Cell Lines Towards Understanding the Mechanism of Cell Recognition [PDF]

, 2013
The recognition of sialic acids by two strains of minute virus of mice (MVM), MVMp (prototype) and MVMi (immunosuppressive), is an essential requirement for successful infection.
Agbandje-McKenna, M, Chen, X, Cotmore, S, Cummings, RD, Dell, A, Halder, S, Haslam, SM, Heimburg-Molinaro, J, McKenna, R, North, SJ, Smith, DF, Tattersall, P, Trollope, AJ   +12 more
core   +1 more source

Imaging single glycans

Nature, 2020
Imaging of biomolecules guides our understanding of their diverse structures and functions1,2. Real-space imaging at sub-nanometre resolution using cryo-electron microscopy has provided key insights into proteins and their assemblies3,4. Direct molecular imaging of glycans-the predominant biopolymers on Earth, with a plethora of structural and ...
Wu, X, Delbianco, M, Anggara, K, Michnowicz, T, Pardo-Vargas, A, Bharate, P, Sen, S, Pristl, M, Rauschenbach, S, Schlickum, U, Abb, S, Seeberger, PH, Kern, K   +12 more
openaire   +3 more sources

Glycan signatures for the identification of cisplatin‐resistant testicular cancer cell lines: Specific glycoprofiling of human chorionic gonadotropin (hCG)

Cancer Medicine, 2022
Background Testicular cancer (TC) is the most frequent type of cancer among young men aged between 15 and 34 years. TC is treated using cisplatin, but 3%–5% of TC patients fail to respond to cisplatin, with a very bad to fatal prognosis.
Michal Hires, Eduard Jane, Katarina Kalavska, Michal Chovanec, Michal Mego, Peter Kasak, Tomas Bertok, Jan Tkac   +7 more
doaj   +1 more source

A theoretical estimate for nucleotide sugar demand towards Chinese Hamster Ovary cellular glycosylation [PDF]

, 2016
Glycosylation greatly influences the safety and efficacy of many of the highest-selling recombinant therapeutic proteins (rTPs). In order to define optimal cell culture feeding strategies that control rTP glycosylation, it is necessary to know how ...
Jimenez del Val, I, Kontoravdi, C, Polizzi, K   +2 more
core   +1 more source

Glycans for good [PDF]

Science Immunology, 2018
The gut commensal bacterium Bifidobacterium bifidum promotes immune tolerance by facilitating the induction of colonic regulatory T cells. See related Research Article by Verma et al .
Katherine A. Kaiser, Nicholas Arpaia
openaire   +2 more sources

Studying Lactoferrin N-Glycosylation. [PDF]

, 2017
Lactoferrin is a multifunctional glycoprotein found in the milk of most mammals. In addition to its well-known role of binding iron, lactoferrin carries many important biological functions, including the promotion of cell proliferation and ...
Barile, Daniela, German, J Bruce, Karav, Sercan, Le Parc, Annabelle, Rouquié, Camille   +4 more
core   +3 more sources

Recognition of specific sialoglycan structures by oral streptococci impacts the severity of endocardial infection. [PDF]

, 2019
Streptococcus gordonii and Streptococcus sanguinis are primary colonizers of the tooth surface. Although generally non-pathogenic in the oral environment, they are a frequent cause of infective endocarditis.
Barnard, Karen N, Bensing, Barbara A, Iverson, TM, Lebrilla, Carlito B, Li, Liang, Parrish, Colin R, Sullam, Paul M, Thomas, Wendy E, Wong, Maurice, Xiong, Yan, Yakovenko, Olga   +10 more
core   +3 more sources