Results 31 to 40 of about 88,542 (309)
Frontiers in Microbiology, 2022 Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines. The extensively glycosylated
Soledad Stagnoli +21 more
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The exploitation of human glycans by Group A Streptococcus
, 2022 Host carbohydrates, or glycans, have been implicated in the pathogenesis of many bacterial infections. Group A Streptococcus (GAS) is a Gram-positive bacterium that readily colonises the skin and oropharynx, and is a significant cause of mortality in ...
Sanderson-Smith, Martina +7 more
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Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the Virion Glycome [PDF]
, 2014 Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins.
Crispin, Max +14 more
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Ion-Mobility Mass Spectrometry of Glycans and Glycopeptides Using Both Intact and Glycan Sequencing Approaches In Positive Ion Mode Facilitates Glycan Isomer and Glycan Motif Identification [PDF]
, 2020 High resolution glycan analysis has become an important part of biopharmaceutical API production and quality control. Liquid chromatography (LC) is now a well-established technique in this field but the resolution of similar isomeric glycan structures is
Sabine, Flitsch +9 more
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Cancer Medicine, 2022 Background Testicular cancer (TC) is the most frequent type of cancer among young men aged between 15 and 34 years. TC is treated using cisplatin, but 3%–5% of TC patients fail to respond to cisplatin, with a very bad to fatal prognosis.
Michal Hires +7 more
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Fluorescent Glycan Derivatives: Their Use for Natural Glycan Microarrays [PDF]
ACS Chemical Biology, 2009 Glycan microarrays have become powerful tools in the investigation of biological systems because they enable fast, quantitative, and simultaneous analysis of glycan-protein interactions with small quantities of samples. One hurdle in the construction of glycan microarrays is to obtain a diverse set of glycans for immobilization on surfaces.
Sungjin, Park +2 more
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Investigating virus–glycan interactions using glycan microarrays [PDF]
Current Opinion in Virology, 2014 While all viruses must transit the plasma membrane of mammalian cells to initiate infection, we know little about the complex processes involved in viral attachment, which commonly involve recognition of glycans by viral proteins. Glycan microarrays derived from both synthetic glycans and natural glycans isolated through shotgun glycomics approaches ...
David F, Smith, Richard D, Cummings
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Glycan Microarrays as Chemical Tools for Identifying Glycan Recognition by Immune Proteins
Frontiers in Chemistry, 2019 Glycans and glycan binding proteins (GBPs or lectins) are essential components in almost every aspect of immunology. Investigations of the interactions between glycans and GBPs have greatly advanced our understanding of the molecular basis of these ...
Chao Gao +5 more
doaj +1 more source
Identification of Isomeric N-glycans by Conformer Distribution Fingerprinting using Ion Mobility-Mass Spectrometry [PDF]
, 2020 Glycans possess unparalleled structural complexity arising from chemically similar monosaccharide building blocks, configurations of anomeric linkages and different branching patterns, potentially giving rise to many isomers.
Corzana, Francisco [0000-0001-5597-8127] +34 more
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Approaching the secrets of N-glycosylation in Aspergillus fumigatus [PDF]
, 2010 The mannosyltransferase Och1 is the key enzyme for synthesis of elaborated protein N-glycans in yeast. In filamentous fungi genes implicated in outer chain formation are present, but their function is unclear.
Engel Jakob +25 more
core +2 more sources