Results 21 to 30 of about 86,469 (209)

Precursor ion scanning for detection and structural characterization of heterogeneous glycopeptide mixtures [PDF]

, 2002
The structure of N-linked glycans is determined by a complex, anabolic, intracellular pathway but the exact role of individual glycans is not always clear.
Gill, A C, Lilley, Kathryn, Ritchie, Mark A, Deery, Michael J, Lilley, K, Gill, Andrew C, Ritchie, M A, Deery, M J   +7 more
core   +1 more source

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Frontiers in Immunology, 2018
Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains.
Fleur S. van de Bovenkamp, Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Steven W. de Taeye, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Rogier W. Sanders, Theo Rispens, Theo Rispens   +13 more
doaj   +1 more source

A brief history of galectin evolution

Frontiers in Immunology, 2023
Galectins are a family of carbohydrate-binding proteins found in vertebrates in great abundance and diversity in terms of both structure and ligand-binding properties as well as physiological function.
Juliane Günther, Sebastian Peter Galuska   +1 more
doaj   +1 more source

Characterization of the single-chain Fv-Fc antibody MBP10 produced in Arabidopsis alg3 mutant seeds [PDF]

, 2010
ER resident glycoproteins, including ectopically expressed recombinant glycoproteins, carry so-called high-mannose type N-glycans, which can be at different stages of processing.
Maurice Henquet, Alexander van der Krol, Mariëlle Schreuder, Schreuder, M., Dirk Bosch, Cordewener, J., Schreuder, M.E.L., Depicker, A., Eigenhuijsen, Jochem, Jan Cordewener, Hesselink, T., Depicker, Anna, Bosch, D., Ann Depicker, Henquet, M.G.L., Spiegel, Holger, Henquet, M., Thamara Hesselink, Spiegel, H., Depicker, AnnaWE098010003776500000-0003-0105-7407F3E47A04-F0ED-11E1-A9DE-61C894A0A6B4, Henquet, Maurice, Jochem Eigenhuijsen, Cordewener, J.H.G., Schreuder, Mariëlle, van der Krol, Alexander, Bosch, H.J., Duijn, E., van, van Duijn, E., Krol, A.R., van der, Hesselink, Thamara, van Duijn, Esther, Cordewener, Jan, Eigenhuijsen, J., Bosch, Dirk, Esther van Duijn, Holger Spiegel, van der Krol, A.R.   +36 more
core   +1 more source

Targeting Galectins With Glycomimetics

Frontiers in Chemistry, 2020
Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation.
Sara Bertuzzi, Jon I. Quintana, Ana Ardá, Ana Gimeno, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero   +6 more
doaj   +1 more source

Anaplasma marginale Infection of Dermacentor andersoni Primary Midgut Cell Culture Is Dependent on Fucosylated Glycans

Frontiers in Cellular and Infection Microbiology, 2022
Tick midgut is the primary infection site required by tick-borne pathogens to initiate their development for transmission. Despite the biological significance of this organ, cell cultures derived exclusively from tick midgut tissues are unavailable and ...
Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell C. Johnson, Hala E. Hussein, Hala E. Hussein, Naomi S. Taus, Kelly A. Brayton, Ulrike G. Munderloh, Susan M. Noh, Susan M. Noh, Massaro W. Ueti, Massaro W. Ueti, Massaro W. Ueti   +12 more
doaj   +1 more source

The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae

Microbiology Spectrum, 2022
Human norovirus (HuNoV) is the major agent for viral gastroenteritis, causing >700 million infections yearly. Fucose-containing carbohydrates named histo-blood group antigens (HBGAs) are known (co)receptors for HuNoV.
Arno Cuvry, Roberto Gozalbo-Rovira, Dufie Strubbe, Johan Neyts, Peter de Witte, Jésus Rodríguez-Díaz, Joana Rocha-Pereira   +6 more
doaj   +1 more source

The Role of Host Cell Glycans on Virus Infectivity: The SARS‐CoV‐2 Case

Advanced Science, 2023
Glycans are ubiquitously expressed sugars, coating the cell and protein surfaces. They are found on many proteins as either short and branched chains or long chains sticking out from special membrane proteins, known as proteoglycans.
Silvia Acosta‐Gutiérrez, Joseph Buckley, Giuseppe Battaglia   +2 more
doaj   +1 more source

Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Frontiers in Microbiology, 2022
Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines. The extensively glycosylated
Soledad Stagnoli, Francesca Peccati, Sean R. Connell, Sean R. Connell, Sean R. Connell, Ane Martinez-Castillo, Diego Charro, Oscar Millet, Chiara Bruzzone, Asis Palazon, Asis Palazon, Ana Ardá, Ana Ardá, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, June Ereño-Orbea, June Ereño-Orbea, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Gonzalo Jiménez-Osés, Gonzalo Jiménez-Osés   +21 more
doaj   +1 more source

From structural to functional glycomics: core substitutions as molecular switches for shape and lectin affinity of N-glycans [PDF]

, 2009
Glycan epitopes of cellular glycoconjugates act as versatile biochemical signals (sugar coding). Here, we test the hypothesis that the common N-glycan modifications by core fucosylation and introduction of the bisecting N-acetylglucosamine moiety have ...
André, Sabine, Kozar, Tibor, Kojima, Shuji, Gabius, Hans-Joachim, Unverzagt, Carlo   +4 more
core   +1 more source