Results 21 to 30 of about 116,660 (304)

Biosynthetic Glycan Labeling [PDF]

Journal of the American Chemical Society, 2021
ABSTRACTGlycans are ubiquitous and play important biological roles, yet chemical methods for probing their structure and function within cells remain limited. Strategies for studying other biomacromolecules, such as proteins, often exploit chemoselective reactions for covalent modification, capture, or imaging.
Victoria M. Marando, Daria E. Kim, Phillip J. Calabretta, Matthew B. Kraft, Bryan D. Bryson, Laura L. Kiessling   +5 more
openaire   +3 more sources

A brief history of galectin evolution

Frontiers in Immunology, 2023
Galectins are a family of carbohydrate-binding proteins found in vertebrates in great abundance and diversity in terms of both structure and ligand-binding properties as well as physiological function.
Juliane Günther, Sebastian Peter Galuska   +1 more
doaj   +1 more source

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Frontiers in Immunology, 2018
Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains.
Fleur S. van de Bovenkamp, Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Steven W. de Taeye, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Rogier W. Sanders, Theo Rispens, Theo Rispens   +13 more
doaj   +1 more source

Probing Virus–Glycan Interactions Using Glycan Microarrays [PDF]

, 2011
Glycan microarrays are surfaces that contain immobilized oligosaccharides or glycoconjugates and have proven useful in probing the interactions between glycan-binding proteins (GBPs) and individual glycans. Such glycan microarrays have been especially important in studying virus-glycan interactions, as most viruses express one or more GBPs important ...
Jamie, Heimburg-Molinaro, Mary, Tappert, Xuezheng, Song, Yi, Lasanajak, Gillian, Air, David F, Smith, Richard D, Cummings   +6 more
openaire   +2 more sources

Anaplasma marginale Infection of Dermacentor andersoni Primary Midgut Cell Culture Is Dependent on Fucosylated Glycans

Frontiers in Cellular and Infection Microbiology, 2022
Tick midgut is the primary infection site required by tick-borne pathogens to initiate their development for transmission. Despite the biological significance of this organ, cell cultures derived exclusively from tick midgut tissues are unavailable and ...
Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell C. Johnson, Hala E. Hussein, Hala E. Hussein, Naomi S. Taus, Kelly A. Brayton, Ulrike G. Munderloh, Susan M. Noh, Susan M. Noh, Massaro W. Ueti, Massaro W. Ueti, Massaro W. Ueti   +12 more
doaj   +1 more source

Cellular O-Glycome Reporter/Amplification to explore O-glycans of living cells [PDF]

, 2015
Protein O-glycosylation has key roles in many biological processes, but the repertoire of O-glycans synthesized by cells is difficult to determine. Here we describe an approach termed Cellular O-Glycome Reporter/Amplification (CORA), a sensitive method ...
Antonopoulos, A, Cummings, RD, Dell, A, Duong, DM, Haslam, SM, Ju, T, Kudelka, MR, Seyfried, NT, Song, X, Wang, Y   +9 more
core   +1 more source

The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae

Microbiology Spectrum, 2022
Human norovirus (HuNoV) is the major agent for viral gastroenteritis, causing >700 million infections yearly. Fucose-containing carbohydrates named histo-blood group antigens (HBGAs) are known (co)receptors for HuNoV.
Arno Cuvry, Roberto Gozalbo-Rovira, Dufie Strubbe, Johan Neyts, Peter de Witte, Jésus Rodríguez-Díaz, Joana Rocha-Pereira   +6 more
doaj   +1 more source

Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]

, 2019
The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B, Li, Qiongyu, Wong, Maurice, Xie, Yixuan   +3 more
core   +2 more sources

Targeting Galectins With Glycomimetics

Frontiers in Chemistry, 2020
Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation.
Sara Bertuzzi, Jon I. Quintana, Ana Ardá, Ana Gimeno, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero   +6 more
doaj   +1 more source

The Role of Host Cell Glycans on Virus Infectivity: The SARS‐CoV‐2 Case

Advanced Science, 2023
Glycans are ubiquitously expressed sugars, coating the cell and protein surfaces. They are found on many proteins as either short and branched chains or long chains sticking out from special membrane proteins, known as proteoglycans.
Silvia Acosta‐Gutiérrez, Joseph Buckley, Giuseppe Battaglia   +2 more
doaj   +1 more source