Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans
, 2023 Background: Pig-derived tissues could overcome the shortage of human donor organs in transplantation. However, the glycans with terminal α-Gal and Neu5Gc, which are synthesized by enzymes, encoded by the genes GGTA1 and CMAH, are known to play a major ...
Dietmar Böthig (21606075) +14 more
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Glycan Fingerprints: Calculating Diversity in Glycan Libraries [PDF]
ACS Chemical Biology, 2012 Carbohydrate libraries printed in glycan micorarray format have had a great impact on the high-throughput analysis of the specificity of a wide range of mammalian, plant, and bacterial lectins. Chemical and chemo-enzymatic synthesis allows the construction of diverse glycan libraries but requires substantial effort and resources.
Rademacher, C., Paulson, J.
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Novel Prostate Cancer Biomarkers: Aetiology, Clinical Performance and Sensing Applications
Chemosensors, 2021 The review initially provides a short introduction to prostate cancer (PCa) incidence, mortality, and diagnostics. Next, the need for novel biomarkers for PCa diagnostics is briefly discussed.
Tomas Bertok +7 more
doaj +1 more source
Progesterone-Induced Sperm Release from the Oviduct Sperm Reservoir
Cells, 2022 In mammalian females, after sperm are deposited in the reproductive tract, a fraction of sperm migrates to the lower oviduct (isthmus) and forms a sperm storage site known as the functional sperm reservoir.
Supipi Mirihagalle +2 more
doaj +1 more source
Glycan microarrays of fluorescently-tagged natural glycans [PDF]
Glycoconjugate Journal, 2015 This review discusses the challenges facing research in 'functional glycomics' and the novel technologies that are being developed to advance the field. The structural complexity of glycans and glycoconjugates makes studies of both their structures and recognition difficult. However, these intricate structures can be captured from their natural sources,
Xuezheng, Song +3 more
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Cell-based glycan arrays for probing glycan–glycan binding protein interactions [PDF]
Nature Communications, 2018 AbstractGlycan microarrays provide a high-throughput means of profiling the interactions of glycan-binding proteins with their ligands. However, the construction of current glycan microarray platforms is time consuming and expensive. Here, we report a fast and cost-effective method for the assembly of cell-based glycan arrays to probe glycan–glycan ...
Jennie Grace Briard +4 more
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Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]
, 2009 We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Huet, Guillemette +8 more
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Viruses, 2018 Glycans are, with nucleic acids, proteins and lipids, one of the four founding structures of cellular life. Due to their non-template synthesis, they are inherently heterogeneous and difficult to study with regards to their structure and function.
Thilo Stehle +3 more
doaj +1 more source
TbGT8 is a bifunctional glycosyltransferase that elaborates N-linked glycans on a protein phosphatase AcP115 and a GPI-anchor modifying glycan in Trypanosoma brucei [PDF]
, 2014 The procyclic form of Trypanosoma brucei expresses procyclin surface glycoproteins with unusual glycosylphosphatidylinositol-anchor side chain structures that contain branched N-acetyllactosamine and lacto-N-biose units.
Hashida, Kazunori +7 more
core +1 more source
Are glycan biosensors an alternative to glycan microarrays? [PDF]
Anal. Methods, 2014 Complex carbohydrates (glycans) play an important role in nature and study of their interaction with proteins or intact cells can be useful for understanding many physiological and pathological processes.
A. Hushegyi, J. Tkac
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