Results 11 to 20 of about 3,532 (161)

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Frontiers in Immunology, 2018
Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains.
Fleur S. van de Bovenkamp, Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Steven W. de Taeye, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Rogier W. Sanders, Theo Rispens, Theo Rispens   +13 more
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Anaplasma marginale Infection of Dermacentor andersoni Primary Midgut Cell Culture Is Dependent on Fucosylated Glycans

Frontiers in Cellular and Infection Microbiology, 2022
Tick midgut is the primary infection site required by tick-borne pathogens to initiate their development for transmission. Despite the biological significance of this organ, cell cultures derived exclusively from tick midgut tissues are unavailable and ...
Rubikah Vimonish, Janaina Capelli-Peixoto, Wendell C. Johnson, Hala E. Hussein, Hala E. Hussein, Naomi S. Taus, Kelly A. Brayton, Ulrike G. Munderloh, Susan M. Noh, Susan M. Noh, Massaro W. Ueti, Massaro W. Ueti, Massaro W. Ueti   +12 more
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The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae

Microbiology Spectrum, 2022
Human norovirus (HuNoV) is the major agent for viral gastroenteritis, causing >700 million infections yearly. Fucose-containing carbohydrates named histo-blood group antigens (HBGAs) are known (co)receptors for HuNoV.
Arno Cuvry, Roberto Gozalbo-Rovira, Dufie Strubbe, Johan Neyts, Peter de Witte, Jésus Rodríguez-Díaz, Joana Rocha-Pereira   +6 more
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Targeting Galectins With Glycomimetics

Frontiers in Chemistry, 2020
Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation.
Sara Bertuzzi, Jon I. Quintana, Ana Ardá, Ana Gimeno, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero   +6 more
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The Role of Host Cell Glycans on Virus Infectivity: The SARS‐CoV‐2 Case

Advanced Science, 2023
Glycans are ubiquitously expressed sugars, coating the cell and protein surfaces. They are found on many proteins as either short and branched chains or long chains sticking out from special membrane proteins, known as proteoglycans.
Silvia Acosta‐Gutiérrez, Joseph Buckley, Giuseppe Battaglia   +2 more
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Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods

Frontiers in Microbiology, 2022
Two years after its emergence, the coronavirus disease-2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains difficult to control despite the availability of several vaccines. The extensively glycosylated
Soledad Stagnoli, Francesca Peccati, Sean R. Connell, Sean R. Connell, Sean R. Connell, Ane Martinez-Castillo, Diego Charro, Oscar Millet, Chiara Bruzzone, Asis Palazon, Asis Palazon, Ana Ardá, Ana Ardá, Jesús Jiménez-Barbero, Jesús Jiménez-Barbero, June Ereño-Orbea, June Ereño-Orbea, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Nicola G. A. Abrescia, Gonzalo Jiménez-Osés, Gonzalo Jiménez-Osés   +21 more
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Glycan signatures for the identification of cisplatin‐resistant testicular cancer cell lines: Specific glycoprofiling of human chorionic gonadotropin (hCG)

Cancer Medicine, 2022
Background Testicular cancer (TC) is the most frequent type of cancer among young men aged between 15 and 34 years. TC is treated using cisplatin, but 3%–5% of TC patients fail to respond to cisplatin, with a very bad to fatal prognosis.
Michal Hires, Eduard Jane, Katarina Kalavska, Michal Chovanec, Michal Mego, Peter Kasak, Tomas Bertok, Jan Tkac   +7 more
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Glycan Microarrays as Chemical Tools for Identifying Glycan Recognition by Immune Proteins

Frontiers in Chemistry, 2019
Glycans and glycan binding proteins (GBPs or lectins) are essential components in almost every aspect of immunology. Investigations of the interactions between glycans and GBPs have greatly advanced our understanding of the molecular basis of these ...
Chao Gao, Mohui Wei, Tanya R. McKitrick, Alyssa M. McQuillan, Jamie Heimburg-Molinaro, Richard D. Cummings   +5 more
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Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis

Frontiers in Molecular Biosciences, 2020
TorsinA is a AAA+ ATPase involved in the severe neurological disease Early Onset Torsion Dystonia. Despite the impressive progress in the field in the recent years, the structural organization and function of this intriguing molecule is still not clear ...
Christian Fercher, Lucía F. Zacchi
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Sialylated and sulfated N-Glycans in MDCK and engineered MDCK cells for influenza virus studies

Scientific Reports, 2022
The Madin-Darby canine kidney (MDCK) cell line is an in vitro model for influenza A virus (IAV) infection and propagation. MDCK-SIAT1 (SIAT1) and humanized MDCK (hCK) cell lines are engineered MDCK cells that express N-glycans with elevated levels of ...
Lauren Byrd-Leotis, Nan Jia, Yasuyuki Matsumoto, Dongli Lu, Yoshihiro Kawaoka, David A. Steinhauer, Richard D. Cummings   +6 more
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