Results 151 to 160 of about 93,224 (271)

Loss of Beta‐Cell Identity and Function as a Mechanism of Secondary Failure of Sulfonylurea Therapy in Diabetes

MedComm, Volume 7, Issue 2, February 2026.
ABSTRACT Sulfonylureas, commonly used to treat type 2 diabetes (T2D), often lose effectiveness over time when used as monotherapy; however, the underlying mechanisms remain unclear. To investigate the mechanisms of sulfonylurea failure, glibenclamide‐releasing pellets were implanted in KK mice, a polygenic model that spontaneously develops T2D. KK mice
Sumit Patel, Zihan Yan, Maria S. Remedi
wiley   +1 more source

Bovine Milk Extracellular Vesicles Modulate Alveolar Bone Microarchitecture and Mitigate Hepatic Steatosis in Obese Mice Fed a High‐Fat Diet

Molecular Nutrition &Food Research, Volume 70, Issue 3, 13 February 2026.
Obesity induced by an HF diet led to increased adiposity, bone loss in the femur and maxilla, metabolic changes, and fatty liver in mice. Treatment with MEVs did not alter adiposity, metabolic changes, or femoral bone loss, but reduced alveolar bone loss and fat deposition in the liver of obese mice. Created in BioRender. Ferreira, A.
Francine R. F. Silva, Joyce E. Heredia, Bruna C. Oliveira, Onno J. Arntz, Talita Martins, Eduardo H. M. Nunes, Mauro M. Teixeira, Tarcilia A. Silva, Fons A. J. van de Loo, Soraia Macari, Adaliene V. M. Ferreira, Marina C. Oliveira   +11 more
wiley   +1 more source

Diabetes mellitus and coronary atherosclerosis

Атеросклероз, 2011
Diabetic patients have the excess risk of developing atherosclerotic coronary artery disease (CAD), which is the most common cause of death in diabetes. The major contributor to the increased CAD risk in patients with type 2 diabetes is dyslipidemia. The
V. I. Volkov, S. A. Serik
doaj  

Preventive Effect of Powder Bergamot Juice (Citrus bergamia Risso & Poiteau) on Pathophysiological Processes of Renal Disease in an Experimental Western Diet Model

Molecular Nutrition &Food Research, Volume 70, Issue 3, 13 February 2026.
Excessive intake of sugars and fats contributes to obesity and renal dysfunction. Natural bioactive compounds, such as those found in bergamot (Citrus bergamia), have been studied for their protective potential. In an experimental rat model, bergamot supplementation reduced weight gain, improved kidney function, and decreased oxidative stress markers ...
Marina de Paula Salomé dos Santos, Juliana Silva Siqueira, Erika Tiemi Nakandakare‐Maia, Taynara Aparecida Vieira, Núbia Alves Grandini, Thiago Luiz Novaga Palacio, Luís Eduardo Sormani, Caíque Manentti Caccia, Jordanna Cruzeiro, Fabiane Valentini Francisqueti‐Ferron, Camila Renata Corrêa   +10 more
wiley   +1 more source

Metabolic Outcomes in Patients With Type 2 Diabetes Prescribed Incretin‐Based Therapy and Referred or Not to a Weight Management Clinic: A Single‐Center Retrospective Analyses

Obesity Science &Practice, Volume 12, Issue 1, February 2026.
ABSTRACT Background Incretin therapies yield strong metabolic improvements, but whether adding a weight‐management (WM) clinic confers additional benefit beyond pharmacotherapy alone in routine care is unclear. Objective Evaluate whether referral to WM clinic, alongside standard diabetes care, provides additional benefit for adults with type 2 diabetes
Kathleen M. Robinson, Stephanie H. Rodriguez, Cyril Pedagarla, Patrick Ten Eyck, Marcelo Correia, Ayotunde Dokun   +5 more
wiley   +1 more source

Penile vascular status in young men living with HIV experiencing erectile dysfunction: A comparative cross‐sectional pilot study

Andrology, Volume 14, Issue 2, Page 377-384, February 2026.
Abstract Background Erectile dysfunction in people living with HIV is a multifactorial disease, but the role of penile vascular status assessed by dynamic penile color Doppler echography is underexplored. Objectives This study assessed penile vascular status in young males living with HIV experiencing erectile dysfunction, comparing them to HIV ...
Giorgio Tiecco, Andrea Delbarba, Cosimo Colangelo, Marco Di Gregorio, Paolo Facondo, Matteo Riva, Carlo Cappelli, Emanuele Focà, Francesco Castelli, Eugenia Quiros‐Roldan   +9 more
wiley   +1 more source

Continuous glucose monitoring and microvascular complications in diabetes: Bridging glycemic metrics with clinical outcomes

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 840-849, February 2026.
Abstract Continuous glucose monitoring (CGM) has emerged as a complementary and more dynamic method for evaluating glycemic control in people with diabetes. Relevant studies examining the association between CGM parameters, including time in range (TIR), glycemic variability (GV), and time in tight range (TITR), and diabetic nephropathy, retinopathy ...
Lilian Anagnostopoulou, Alexandros L. Liarakos, Ioannis Ntanasis‐Stathopoulos, Alexandros Briasoulis, Anastasios Tentolouris   +4 more
wiley   +1 more source

Heart matters: How glucose‐ and lipid‐modulating drugs remodel epicardial adipose tissue accumulation, inflammatory patterns and browning

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 878-894, February 2026.
Abstract Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot located between the myocardium and the visceral pericardium, exerting direct paracrine and vasocrine effects on the heart and coronary vessels. Under physiological conditions, EAT supports myocardial energy metabolism and thermoregulation through fatty acid supply and
Elisabeth Heuboeck, Charnkamal Singh Bhogal, Markus Mandl   +2 more
wiley   +1 more source

[Sugary drinks and glycemia].

Acta medica portuguesa, 2010
Obesity prevalence is increasing all over the world. Most affected are people changing from a traditional lifestyle to an environment with both availability of high energy diet and less physical activity. Glycemic index (GI) is a measure of dietary glycemic carbohydrates, representing their ability to raise blood glucose concentrations.
Susana, Guerreiro, Manuel, Alçada, Isabel, Azevedo   +2 more
openaire   +1 more source

Unintentional periconceptional exposure to glucagon‐like peptide‐1 receptor agonists and adverse pregnancy outcomes: A nationwide cohort study in Taiwan

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1420-1430, February 2026.
Abstract Aims To assess whether periconceptional exposure to glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) is associated with adverse outcomes in women with pregestational type 2 diabetes. Materials and Methods We linked Taiwan's Birth Certificate Application and National Health Insurance claims (2013–2022) to assemble a nationwide cohort of ...
Yi‐Chang Chou, Shih‐Han Weng, Feng‐Shiang Cheng, Chih‐Hao Tseng, Hsiao‐Yun Hu, Chieh‐Hsing Liu   +5 more
wiley   +1 more source