Results 61 to 70 of about 93,224 (271)

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Does lambing season affect mother-young relationships and lamb vigor in D’man sheep reared in oases?

Animal, 2020
Although sheep are known to be seasonal breeders and give birth in winter, not all of them follow this trend. A few breeds can be mated and give birth all year round, meaning that mothers and neonates will have to face contrasting climatic conditions ...
A. Dhaoui, M. Chniter, F. Lévy, R. Nowak, M. Hammadi   +4 more
doaj   +1 more source

Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]

, 2014
Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying, Dang, Hoa, Kaufman, Daniel L, Nguyen, An Viet, Tian, Jide   +4 more
core   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

What's in a Name? Classification of Diabetes Mellitus in Veterinary Medicine and Why It Matters [PDF]

, 2016
Diabetes Mellitus (DM) is a syndrome caused by various etiologies. The clinical manifestations of DM are not indicative of the cause of the disease, but might be indicative of the stage and severity of the disease process.
Abdul-Rasoul, Agarwal, Ahlgren, Alejandro, American Diabetes Association, Anderson, Appleton, Atkins, Atkins, Batchelor, Belle, Bostrom, Brackeva, Brenner, Butler, Catchpole, Catchpole, Chiang, Concannon, Coppieters, Cui, Das, Davison, Davison, Davison, De Cock, Eigenmann, Fajans, Fall, Forcada, Forcada, Forsberg, Furrer, Gepts, Gilor, Gilor, Gilor, Girman, Goossens, Gostelow, Gottlieb, Guptill, Haines, Hall, Herold, Hess, Hewson-Hughes, Hoenig, Hoenig, Hoffmann, Holst, Hume, Imamura, Jensen, Kappe, Kennedy, Kenny, Kilpatrick, Kim, Kitamura, Klupa, Kramer, Kramer, Lem, Ling, Link, Lutz, Mattin, McDonald, Miceli, Michels, Neiger, Nelson, Nelson, Niessen, Niessen, Nishii, Orban, Panciera, Papa, Pietropaolo, Porte, Porte, Prahl, Prasad, Rand, Ranta, Reaven, Russell-Jones, Safra, Scudder, Shields, Slingerland, Solanki, Strage, Sun, Temple, Thomas, Vegiopoulos, Verkest, Watson, Watson, Williams, Xenoulis, Yang, Zini, Zini, Zini, Zini, Zini, Zini   +110 more
core   +3 more sources

Fibers as Oleogelators: Innovations, Applications, and Future Prospects in Structured Lipid Systems

Journal of the American Oil Chemists' Society, EarlyView.
Schematic overview of fiber‐based oleogelation mechanisms, processing routes, and food applications highlighting particulate/capillary structuring, polymer entanglement, and emulsion‐templated approaches. ABSTRACT Oleogels, structured oil systems created with low levels of gelators‐enables solid fat functionality while preserving the underlying liquid ...
P. Abdul Wahid, Rajni Chopra, Nitin Kumar, Monika Chand, Aishwarya Dhiman, Rajat Singh   +5 more
wiley   +1 more source

Severe brain injury management [PDF]

Romanian Journal of Neurology, 2009
Management of severe brain injury, the main cause of death in young population, has now standardized principles that lead to the improving of the outcome. The treatment of this traumatic illness is directly connected to cerebral physiopathology.
Eva Gheorghita, Cristina Bucur, Luminita Neagoe, Jean Ciurea, Jemna Constantin   +4 more
doaj   +1 more source

Comparison of glycemic excursion in patients with new onset type 2 diabetes mellitus before and after treatment with repaglinide [PDF]

, 2013
Due to industrialization and sedentary life, incidence of type 2 diabetes (DM2) is increasing seriously. Repaglinide is a glucose reducing agent that predominantly reduces post-prandial glucose.
Bonakdaran, S., Hezarkhani, S., Marjani, A., Rajabian, R., Shahini, N.   +4 more
core   +1 more source

Emulating Six Cardiovascular Outcome Trials of Antidiabetic Drugs in Individuals with Type 2 Diabetes: Analyses Based on Real‐World Databases from Korea and Taiwan

Clinical Pharmacology &Therapeutics, EarlyView.
With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko, Philip C. M. Au, Michael Chun‐Yuan Cheng, Ching‐Lung Cheung, Ahhyung Choi, Miyuki Hsing‐Chun Hsieh, Han Eol Jeong, Edward Chia‐Cheng Lai, Brian Meng‐Hsun Li, Kenneth K. C. Man, Jeremy A. Rassen, Daniel Hsiang‐Te Tsai, Shirley V. Wang, Ian C. K. Wong, Ju‐Young Shin, Sohee Park   +15 more
wiley   +1 more source

Dietary Behaviors Among Patients with Type 2 Diabetes Mellitus in YOGYAKARTA, Indonesia [PDF]

, 2011
Purpose: To describe dietary behaviors and examine relationships between selected factors and dietary behaviors among type 2 diabetes mellitus (T2DM) patients in Yogyakarta, Indonesia.Method: Seventy T2DM patients from a hospital in Yogyakarta who met ...
Kritpracha, C. (Charuwan), Primanda, Y. (Yanuar), Thaniwattananon, P. (Ploenpit)   +2 more
core   +2 more sources