Results 251 to 260 of about 307,887 (342)

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN‐2‐Mediated Changes

open access: yesAging Cell, EarlyView.
Changes in mitochondrial structure and dynamics during aging provide a mechanism for the development of age‐related sarcopenia, a condition characterized by muscle mass loss. Through the creation of three‐dimensional models of mitochondria from quadriceps muscle tissue taken from old and young humans, a loss in mitochondrial complexity was observed to ...
Estevão Scudese   +52 more
wiley   +1 more source

How to take action beyond ambulatory glucose profile: Latin American expert recommendations on CGM data interpretation. [PDF]

open access: yesDiabetol Metab Syndr
Calliari LE   +8 more
europepmc   +1 more source

Assessing gout risk associated with GLP‐1 therapy in obese patients with type 2 diabetes: A retrospective cohort study

open access: yes
Rheumatology &Autoimmunity, EarlyView.
Justin Riley Lam   +6 more
wiley   +1 more source

SGLT2 Inhibition by Enavogliflozin Significantly Reduces Aβ Pathology and Restores Cognitive Function via Upregulation of Microglial AMPK Signaling in 5XFAD Mouse Model of Alzheimer's Disease

open access: yesAging Cell, EarlyView.
SGLT2 inhibition with Enavogliflozin significantly improves cognitive function and reduces Aβ pathology in the 5XFAD mouse model of Alzheimer's disease. Through AMPK activation, Enavogliflozin enhances microglial mitochondrial function and Aβ phagocytosis while reducing neuroinflammation.
Jihui Han   +5 more
wiley   +1 more source

Accuracy and Safety of a Novel Intravenous Continuous Glucose Monitoring System in Patients Admitted to a Cardiothoracic ICU: A Pilot Trial. [PDF]

open access: yesJ Diabetes Sci Technol
Hochfellner D   +11 more
europepmc   +1 more source

Short‐Term Severe Energy Restriction Promotes Molecular Health and Reverses Aging Signatures in Adults With Prediabetes in the PREVIEW Study

open access: yesAging Cell, EarlyView.
Severe short‐term energy restriction in adults with prediabetes led to a significant reduction in circulating proteins linked to inflammation, senescence, and protein turnover. These changes, partly mediated by extracellular vesicles, suggest systemic dietary‐induced benefits beyond glycemic control, including improved aging biomarkers.
Maria Lastra Cagigas   +16 more
wiley   +1 more source

Management of xylazine toxicity, overdose, dependence, and withdrawal: A systematic review

open access: yesThe American Journal on Addictions, EarlyView.
Abstract Background and Objectives Xylazine, an alpha‐2‐adrenergic agonist, has been increasingly implicated in substance use and overdose crises. However, little is known about its effects on humans. With the growing public health crisis surrounding xylazine, it has become important to recognize and promptly manage symptoms of xylazine toxicity ...
Philipa Owusu‐Antwi   +4 more
wiley   +1 more source

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