Results 91 to 100 of about 42,399 (293)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Ueber die Art, wie das Glycerin Hämoglobinurie macht
, 1879 UEBER DIE ART, WIE DAS GLYCERIN HÄMOGLOBINURIE MACHT Ueber die Art, wie das Glycerin Hämoglobinurie macht (8) (-
Schwahn
core
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Increased urinary losses in piglets fed diets containing high levels of glycerin
Revista Brasileira de Zootecnia, 2019 This study evaluated the nutritional value of glycerin added to diets of weaned piglets and its effects on animal performance and urinary losses. Weaned piglets were individually housed in metabolic cages and fed diets in which a basal diet containing ...
Manuela Marques Fischer +3 more
doaj +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
Crude glycerin levels in pearl millet-based diets for Nellore young bulls in feedlot
Revista Brasileira de Zootecnia, 2016 - The objective of this study was to find the best level of inclusion of crude glycerin (0, 60, 120, and 240 g kg−1 of dry matter of diet) in substitution of pearl millet in a feedlot diet.
Werney da Silva Moreira +5 more
doaj +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Derivate von Aminosäuren. I. Mitteilung. 1. Verbindungen mit Glycerin
, 1910 DERIVATE VON AMINOSÄUREN. I. MITTEILUNG. 1. VERBINDUNGEN MIT GLYCERIN Details: Zeitschrift für physiologische Chemie: 1.1877-20.1895 Hoppe-Seyler's Zeitschrift für physiologische Chemie: 21.1895- 112.1921 (-) Hoppe-Seyler's Zeitschrift für ...
Abderhalden, Emil Markus Guggenheim
core +1 more source