Results 231 to 240 of about 42,399 (293)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Assessment of dentinal fluid flow reduction following simulated brushing with desensitizing toothpastes using sub-nanoliter fluid flow measurement system. [PDF]

BMC Oral Health
Kim S, Lee IB, Truong VM, Lee W, Park YS.   +4 more
europepmc   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Development and Mechanical Characterization of Novel Gelatin-Fish Oil Composite Hydrogel for 3D Bioprinting. [PDF]

Biomimetics (Basel)
Milosevic D, Brankovic M, Virijevic K, Kotorcevic N, Milojevic D, Mihailovic N, Grujovic N, Zivic F.   +7 more
europepmc   +1 more source

Space Jam‐Ming: Generating Interstitial Space Using Fragmented Granular GelMA to Investigate Novel Paradigms of Cancer Metastasis

Advanced Science, EarlyView.
Microgels enable independent control of stiffness and interstitial space, overcoming limitations of conventional 3D hydrogels. Using fragmented gelatin methacryloyl microgels, we show that stiffness does not restrict non‐metastatic breast cancer growth, contrary to bulk hydrogels, and reveal the role of adherent‐to‐suspension transition in cancer ...
Danielle Vahala, Zhuang Min Lee, Sebastian E. Amos, Dong Woo Son, Jong Hwa Byun, Farzan Navaeipour, Jiayue Li, Kai L. Metzner, Ji Hoon Jeong, Juyeon Kim, Yongsung Hwang, Brendan F. Kennedy, Khoon S. Lim, Hee Seung Lee, Hyun Woo Park, Yu Suk Choi   +15 more
wiley   +1 more source

Analysis of the Elnady Technique on Cadaveric Tissues: A Low Barrier-to-Entry to Increase Tissue Handling Comfort, Longevity, and Safety. [PDF]

Cureus
Harris GG, Jones JM, McNary TG.
europepmc   +1 more source

The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells

Advanced Science, EarlyView.
Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato, Jesús A. Andrés‐San Román, Juan Garrido‐García, Carmen Gordillo‐Vázquez, Ana M. Palacios, Elisabeth Lidueña‐Fernández, Katie McDole, Pedro Gómez‐Gálvez, Valentina Annese, Luis M. Escudero   +9 more
wiley   +1 more source

The Effect of Brushing and Post-Processing Procedures on the Optical Properties of Printed Dental Resin. [PDF]

Polymers (Basel)
Vasiliu RD, Porojan L, Bejan FR, Porojan SD, Matichescu A.   +4 more
europepmc   +1 more source

Investigation of Antioxidant Properties of Propolis Products Collected from Different Regions. [PDF]

Int J Mol Sci
Cetin A, Bakir S, Ozdal T, Capanoglu E.
europepmc   +1 more source

Micro Blood Flow-Resolved Rheometry. [PDF]

Micromachines (Basel)
Kang YJ.
europepmc   +1 more source