Results 51 to 60 of about 667,395 (258)

Induced encystment improves resistance to preservation and storage of Acanthamoeba castellanii [PDF]

, 2008
Several conditions that allow the preservation, storage and rapid, efficient recovery of viable Acanthamoeba castellanii organisms were investigated. The viability of trophozoites (as determined by time to confluence) significantly declined over a period
Campbell, S. J., Roberts, C. W., Ingram, P. R., Henriquez, F. L.   +3 more
core   +3 more sources

Glycerol contained in vaping liquids affects the liver and aspects of energy homeostasis in a sex‐dependent manner

Physiological Reports, 2022
Vaping is increasingly popular among the young and adult population. Vaping liquids contained in electronic cigarettes (e‐cigarettes) are mainly composed of propylene glycol and glycerol, to which nicotine and flavors are added.
Ariane Lechasseur, Mathilde Mouchiroud, Félix Tremblay, Gabrielle Bouffard, Nadia Milad, Marie Pineault, Michaël Maranda‐Robitaille, Joanie Routhier, Marie‐Josée Beaulieu, Sophie Aubin, Mathieu Laplante, Mathieu C. Morissette   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Biochemical studies on plant glycerol-3- phosphate acyltransferase [PDF]

, 2003
sn-Glycerol-3-phosphate acyltransferase [G3PAT, PlsB (E.coli), EC 2.3.1.15] is an enzyme involved in glycerolipid biosynthesis, catalysing the acylation of glycerol-3-phosphate (G3P) to produce lysophosphatidic acid (LPA). Chilling tolerance in plants is
Hayman, Matthew William
core  

RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]

, 2014
Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry, Curry, Edward, Myrsini Kaforou, Cinti, S, Cinti, Saverio, Saverio Cinti, Lemonia Chatzeli, Parker, MG, Kiskinis, E, Kiskinis, Evangelos, Kaforou, M, Frontini, A, Chatzeli, Lemonia, Montana, G, Chatzeli, L, Curry, E, Kaforou, Myrsini, Evangelos Kiskinis, Montana, Giovanni, Christian, Mark, Giovanni Montana, Frontini, Andrea, Mark Christian, Parker, Malcolm G., Christian, M, Malcolm G. Parker   +25 more
core   +1 more source

Simplified fluorometric method for the determination of plasma glycerol

Journal of Lipid Research, 1970
A simplified method for determining plasma glycerol is described. This assay utilizes the fluorometric measurement of the reduced adenine dinucleotide, NADH2 which is formed when glycerol is oxidized by glycerol dehydrogenase.
Mayer B. Davidson, Robert Karjala
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Saccharomyces cerevisiae exhibiting a modified route for uptake and catabolism of glycerol forms significant amounts of ethanol from this carbon source considered as ‘non-fermentable’

Biotechnology for Biofuels, 2019
Background Due to its inevitable formation during biodiesel production and its relatively high degree of reduction, glycerol is an attractive carbon source for microbial fermentation processes.
Maximilian R. Aßkamp, Mathias Klein, Elke Nevoigt   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source