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Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial
The Lancet, 2019 Summary Background High blood pressure is common in acute stroke and is a predictor of poor outcome; however, large trials of lowering blood pressure have given variable results, and the management of high blood pressure in ultra-acute stroke remains ...Philip M Polly Craig S Jason P Evind Lesley Mark Timothy Bath Scutt Anderson Appleton Berge Cala Dixon Engl, P. Bath, Polly Scutt, C. Anderson, J. Appleton, E. Berge, L. Cala, M. Dixon, T. England, P. Godolphin, D. Havard, Lee J Haywood, T. Hepburn, K. Krishnan, Grant Mair, A. Montgomery, K. Muir, S. Phillips, S. Pocock, John Potter, C. Price, M. Randall, T. Robinson, C. Roffe, P. Rothwell, E. Sandset, N. Sanossian, J. Saver, A. Shone, A. Siriwardena, J. Wardlaw, L. Woodhouse, G. Venables, N. Sprigg, P. Amarenco, S. Amoils, M. Jarvis, P. Sandercock, K. Asplund, C. Baigent, Sandeep Ankolekar, Harriet Howard, C. Lysons, G. Walker, H. Gregory, James Kirby, J. Smithson, J. Keeling, N. Frowd, R. Gray, R. Dooley, Wim Clarke, P. Robinson, Z. Law, S. Hodgson, A. Millington, E. Sakka, David Buchanan, Jeb Palmer, D. Shaw, H. Cobb, R. Johnson, T. Payne, R. Spaight, A. Spaight, M. Sajid, A. Whileman, E. Hall, H. Cripps, J. Toms, R. Gascoyne, S. Wright, M. Cooper, A. Palfreman, A. Rajapakse, I. Wynter, K. Musarrat, A. Mistri, C. Patel, C. Stephens, S. Khan, S. Patras, M. Soliman, A. Elmarimi, C. Hewitt, E. Watson, I. Wahishi, J. Hindle, L. Perkin, M. Wills, S. Arif, S. Leach, S. Butler, D. O’Kane, C. Smith, J. O’Callaghan, W. Sunman, A. Buck, B. Jackson, C. Richardson, G. Wilkes, J. Clarke, L. Ryan, O. Matias, D. Mangion, A. Hardwick, C. Constantin, I. Thomas, K. Netherton, S. Markova, A. Hedstrom, B. Rushton, C. Hyde, J. Scott, M. Blair, M. Maddula, R. Donnelly, S. Keane, S. Johnson, H. McKenzie, A. Banerjee, D. Hutchinson, H. Goodhand, J. Hill, K. Mellows, M. Cheeseman, V. McTaggart, T. Foster, L. Prothero, P. Saksena, A. O'Kelly, H. Wyllie, C. Hacon, H. Nutt, J. North, K. Goffin, J. Potter, A. Wiltshire, G. Ravenhill, K. Metcalf, L. Ford, M. Langley, W. Davison, S. Subramonian, F. Magezi, I. Obi, N. Temple, N. Butterworth-Cowin, P. Oqwusu-Agyei, A. Azim, A. Nicolson, J. Imam, J. White, L. Wood, R. Fothergill, N. Thompson, J. Lazarus, H. Werts, L. Sztriha, C. Ho, E. Mckenzie, E. Owoyele, J. Lim, J. Aeron-Thomas, M. Dockey, N. Sylvester, P. Rao, B. Bloom, E. Erumere, G. Norman, I. Skene, L. Cuenoud, L. Howaniec, O. Boulton, P. Daboo, R. Michael, S. Alsaadi, T. Harrison, H. Syed, L. Argandoña, S. Amiani, R. Perry, A. Ashton, A. Banaras, C. Hogan, C. Watchurst, E. Elliott, N. Francia, N. Oji, R. Erande, S. Obarey, S. Feerick, S. Tshuma, E. England, H. Pocock, K. Poole, S. Manchanda, I. Burn, S. Dayal, K. McNee, M. Robinson, R. Hancock, A. South, C. Holmes, A. Steele, L. Guthrie, M. Oborn, A. Nor, B. Hyams, C. Eglinton, D. Waugh, E. Cann, N. Wilmhurst, S. Piesley, S. Shave, D. Dutta, M. Obeid, D. Ward, J. Turfrey, J. Glass, K. Bowstead, L. Hill, P. Brown, S. Beames, S. O'Connell, V. Hughes, R. Whiting, J. Gagg, M. Hussain, M. Harvey, D. Karunatilake, B. Pusuluri, A. Witcher, C. Pawley, J. Allen, J. Foot, J. Rowe, C. Lane, S. Ragab, B. Wadams, J. Dube, B. Jupp, A. Ljubez, C. Bagnall, G. Hann, L. Tucker, M. Kelton, S. Orr, F. Harrington, A. James, A. Lydon, G. Courtauld, K. Bond, L. Lucas, T. Nisbett, J. Kubie, A. Bowring, G. Jennings, K. Thorpe, N. Mason, S. Keenan, L. Gbadomishi, D. Howcroft, H. Newton, J. Choulerton, J. Avis, L. Shaw, P. Paterson, P. Kaye, S. Hierons, S. Lucas, P. Clatworthy, B. Faulkner, L. Rannigan, R. Worner, B. Bhaskaran, A. Saulat, H. Bearne, J. Garfield-Smith, K. Horan, P. Fitzell, S. Szabo, M. Haley, D. Simmons, D. Cotterill, G. Saunders, H. Dymond, S. Beech, K. Rashed, A. Tanate, C. Buckley, D. Wood, L. Matthews, S. Board, T. Pitt-Kirby, N. Rees, C. Convery, P. Jones, C. Bryant, H. Tench, M. Dixon, R. Loosley, S. Coetzee, S. Jones, T. Sims, M. Krishnan, C. Davies, L. Quinn, L. Connor, M. Wani, S. Storton, S. Treadwell, T. Anjum, C. Somashekar, A. Chandler, C. Triscott, L. Bevan, M. Sander, S. Buckle, W. Sayed, K. Andrews, L. Hughes, R. Hughes, M. Ward, A. Pretty, A. Rosser, B. Davidson, G. Price, I. Gunson, J. Lumley-Holmes, J. Miller, M. Lardén, M. Jhamat, P. Horwood, R. Boldy, C. Jenkins, F. Price, M. Harrison, T. Martin, N. Ahmad, A. Willberry, A. Stevens, K. Fotherby, A. Barry, A. Remegoso, F. Alipio, H. Maquire, J. Hiden, K. Finney, R. Varquez, S. Ispoglou, A. Hayes, D. Gull, R. Evans, E. Epstein, S. Hurdowar, J. Crossley, J. Miles, K. Hird, R. Pilbery, C. Patterson, H. Ramadan, K. Stewart, O. Quinn, R. Bellfield, S. Macquire, W. Gaba, A. Nair, A. Wilson, C. Hawksworth, I. Alam, J. Greig, P. Gomes, P. Rana, Z. Ahmed, P. Anderston, A. Neal, D. Walstow, R. Fong, S. Brotheridge, A. Bwalya, A. Gillespie, C. Midgley, C. Hare, H. Lyon, L. Stephenson, M. Broome, R. Worton, S. Jackson, R. Rayessa, A. Abdul-Hamid, C. Naylor, E. Clarkson, A. Hassan, E. Veraque, L. Finch, L. Makawa, M. Carpenter, P. Datta, A. Needle, L. Jackson, H. Brooke, J. Ball, T. Lowry, S. Punnoose, R. Walker, V. Murray, A. Ali, C. Kamara, C. Doyle, E. Richards, J. Howe, K. Dakin, K. Harkness, R. Lindert, P. Wanklyn, P. Willcoxson, P. Clark-Brown, R. Mir +418 moresemanticscholar +1 more sourceA non-operative management of chronic anal fissure.
Journal of Gandhara Medical and Dental Sciences, 2018
OBJECTIVES
Assessment of efficacy of topical 0.2% glyceryl trinitrate ointment in the treatment of chronic anal fissure.
PATIENTS AND METHODS
A prospective study was carried out at surgical outpatient department Town Teaching Hospital from January 2017 ...Azhar Shahdoaj +1 more sourceTRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice
Brain : a journal of neurology, 2018 Glyceryl trinitrate administration causes prolonged mechanical allodynia in rodents, which correlates temporally with delayed migraine attacks in patients. Marone et al. show that the allodynia is mediated by TRPA1 activation in cell bodies of trigeminal I. Marone, Francesco De Logu, R. Nassini, M. de Carvalho Gonçalves, S. Benemei, J. Ferreira, P. Jain, Simone Li Puma, N. Bunnett, P. Geppetti, Serena Materazzi +10 moresemanticscholar +1 more sourcePrehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage
Stroke, 2019 Supplemental Digital Content is available in the text.P. Bath, L. Woodhouse, K. Krishnan, J. Appleton, C. Anderson, E. Berge, L. Cala, M. Dixon, T. England, P. Godolphin, T. Hepburn, Grant Mair, Alan A. Montgomery, Stephen J. Phillips, J. Potter, Chris I. Price, M. Randall, Thompson G. Robinson, C. Roffe, Peter M. Rothwell, E. Sandset, N. Sanossian, Jeffrey Saver, A. N. Siriwardena, G. Venables, Joanna M. Wardlaw, N. Sprigg +26 moresemanticscholar +1 more sourceReduced perfusion in systemic sclerosis digital ulcers (both fingertip and extensor) can be increased by topical application of glyceryl trinitrate
Microvascular Research, 2017 Objectives In patients with systemic sclerosis (SSc), fingertip digital ulcers (DUs) are believed to be ischaemic, and extensor surface DUs a result of mechanical factors/microtrauma.Michael Hughes, T. Moore, T. Moore, J. Manning, Jack Wilkinson, G. Dinsdale, C. Roberts, A. Murray, A. Murray, A. Herrick +9 moresemanticscholar +1 more source