Results 41 to 50 of about 16,833 (197)

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source

Efficacy of glyceryl trinitrate in reducing cardiac events when given concomitantly with capecitabine for at least 3 months in various tumors

Pakistan Journal of Pharmaceutical Sciences
Capecitabine is an oral pro-drug of 5-flourouracil used in treatment of different cancers. It has cardiotoxicity incidence of 3-35%, which can be significant enough to cause myocardial infarction.
Zeeshan Ahmed Khan Niazi, Amjad Zafar, Zaigham Ismail, Harris Siddiqi, Hafsa Naseer, Asma Abdul Rashid   +5 more
doaj   +1 more source

Ictal lack of binding to brain parenchyma suggests integrity of the blood–brain barrier for 11 C-dihydroergotamine during glyceryl trinitrate-induced migraine

Brain : a journal of neurology, 2016
See Dreier (doi: 10.1093/aww112 ) for a scientific commentary on this article. Breakdown of the blood–brain barrier has long been postulated to occur in migraine. Schankin et al. explore this possibility using PET with [ 11 C]-dihydroergotamine.
C. Schankin, F. Maniyar, Youngho Seo, S. Kori, M. Eller, D. Chou, J. Blecha, S. Murphy, R. Hawkins, T. Sprenger, H. VanBrocklin, P. Goadsby   +11 more
semanticscholar   +1 more source

Impact of Heated Versus Unheated Cooking Oil on Postprandial Vascular Function and Metabolism

Lipids, EarlyView.
ABSTRACT The impact of repeated heating of seed‐based culinary oils on cardiometabolic health has not been well established. Heating oils to high temperatures (> 150°C) causes lipid peroxidation, thus generating potentially harmful compounds that may impair vascular function. This randomized, single‐blind, crossover study investigated the acute effects
Rosiered Brownson‐Smith, Jo Bruce, Esmat Abbas, Sarah Fissler, Wendy Hall, Sarah Berry   +5 more
wiley   +1 more source

Therapeutic Potential of Transdermal Glyceryl Trinitrate in the Management of Acute Stroke

CNS Drugs, 2016
The nitric oxide donor, glyceryl trinitrate (GTN), is a candidate treatment for the management of acute stroke with haemodynamic and potential reperfusion and neuroprotective effects. When administered as a transdermal patch during the acute and subacute
J. Appleton, N. Sprigg, P. Bath
semanticscholar   +1 more source

Methaemoglobinaemia: From pathophysiology to contemporary clinical management

British Journal of Haematology, EarlyView.
Summary Methaemoglobin (MetHb) is an oxidised form of haemoglobin (Hb) unable to bind oxygen. Raised levels of MetHb reduce the blood's oxygen‐carrying capacity, causing potentially severe hypoxaemia and possible death. The condition arises from three main pathologies: mutations in globin genes causing Haemoglobin‐M, inherited deficiency of the enzyme ...
Alexander J. Twine, David C. Rees
wiley   +1 more source

Glyceryl trinitrate ointment in angina pectoris [PDF]

Postgraduate Medical Journal, 1979
Skin absorption of glyceryl trinitrate (GTN) has been recognized for a long time. The effect of GTN and a placebo ointment in prevention of chest pain has been assessed and compared by studying the exercise capacity in 17 patients with angina pectoris. The placebo cream was ineffective but the GTN ointment was found to have beneficial effect in relief ...
H H, Salem, S P, Singh
openaire   +2 more sources

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

Effect of Hyperacute Administration (Within 6 Hours) of Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome After Stroke: Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke (ENOS) Trial

Stroke, 2015
Background and Purpose— Nitric oxide donors are candidate treatments for acute stroke, potentially through hemodynamic, reperfusion, and neuroprotectant effects, especially if given early.
L. Woodhouse, Polly Scutt, K. Krishnan, E. Berge, J. Gommans, G. Ntaios, J. Wardlaw, N. Sprigg, P. Bath   +8 more
semanticscholar   +1 more source

Potential association of cluster headache with certain COVID‐19 vaccines: An assessment from the pharmacovigilance databases

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background The main objective of our study was to assess the potential association between coronavirus disease 2019 (COVID‐19) vaccination and cluster headache (CH) using a pharmacovigilance approach. A secondary objective was to determine whether COVID‐19 vaccines predominantly triggered onset or worsening of the disease.
Elise K. Van Obberghen, Laura Parigny, Nouha Ben‐Othman, Elliot Ewig, Milou‐Daniel Drici, Alexandre O. Gérard, Sophie Gautier, Michel Lanteri‐Minet   +7 more
wiley   +1 more source