Results 101 to 110 of about 1,184,099 (376)

Diastereoselective Three-Component Reactions of Chiral Nickel(II) Glycinate for Convenient Synthesis of Novel α-Amino-β-Substituted-γ,γ-Disubstituted Butyric Acids

Molecules, 2014
The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine.
Rui Zhou, Li Guo, Cheng Peng, Gu He, Liang Ouyang, Wei Huang   +5 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

The Multi-Voxel MRS of Glioma: Glycine is a Suitable Biomarker for Tumor Grading

Advanced Biomedical Research
Background: The goal of this study was to evaluate the role of different metabolites such as glycine, choline (Cho), NAA, and creatinine (Cr) in the grading of glioma in the multi-voxel MRS.
Hossein Taheri, Simin Hemati, Reza Moghareabed, Mohammadbagher Tavakoli, Ali Forouzmehr, Safura Mozafari, Negar Abdi, Yasaman Nilie, Hamed Taheri   +8 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

On the differential hydration of various forms of glycine in diluted aqueous solutions: a Monte Carlo study

Macedonian Journal of Chemistry and Chemical Engineering, 2012
Rigid-body Monte Carlo simulations were carried out to study the differential hydration of zwitterionic and neutral forms of glycine in water. To account for the solute polarization by the rather polar liquid environment, initial geometries were chosen ...
Biljana Bujaroska, Kiro Stojanoski, Ljupco Pejov   +2 more
doaj   +1 more source

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors

Nature Communications, 2018
GluN3A and GluN3B are glycine-binding subunits belonging to the NMDA receptor (NMDAR) family that can assemble with the GluN1 subunit to form unconventional receptors activated by glycine alone.
Teddy Grand, S. Abi Gerges, Mélissa David, Marco A. Diana, P. Paoletti   +4 more
semanticscholar   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Supplementation of Glycine and Glucose into Egg Yolk Lactated Ringer Diluent on The Quality of Local Chicken Semen Stored at 5oC for 120 Hours

Jurnal Medik Veteriner
The impact of supplementing glucose, glycine, or a combination of both in Ringer’s lactate egg yolk base extender to preserve the quality of semen from local Indonesian chickens has not been previously investigated.
Junaedi Junaedi, Nurul Isnaini, Muhammad Halim Natsir, Trinil Susilawati   +3 more
doaj   +1 more source

High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis

Amino Acids, 2018
Collagen synthesis is severely diminished in osteoarthritis; thus, enhancing it may help the regeneration of cartilage. This requires large amounts of glycine, proline and lysine.
Patricia de Paz-Lugo, J. A. Lupiáñez, E. Meléndez-Hevia   +2 more
semanticscholar   +1 more source