Results 71 to 80 of about 3,903 (108)
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Archives of Biochemistry and Biophysics, 1982
Abstract Two glycine-requiring Chinese hamster ovary (CHO) auxotrophs (GLYB and AUXB2) representative of the Gly − mutant classes B and C are shown to have defects in folate metabolism. These defects result in 10-fold lower rates of whole cell l -[U- 14 C]serine-to-[ 14 C]glycine conversion relative to the parental CHO lines (2 vs 20 nmol/h/10 6 ...
R T, Taylor, M L, Hanna
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Abstract Two glycine-requiring Chinese hamster ovary (CHO) auxotrophs (GLYB and AUXB2) representative of the Gly − mutant classes B and C are shown to have defects in folate metabolism. These defects result in 10-fold lower rates of whole cell l -[U- 14 C]serine-to-[ 14 C]glycine conversion relative to the parental CHO lines (2 vs 20 nmol/h/10 6 ...
R T, Taylor, M L, Hanna
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Biophysical Chemistry, 2005
Cytosolic Plasmodium falciparum serine hydroxymethyltransferase (pfSHMT) is a potential target for antimalarial chemotherapy. Contrasting with the other enzymes involved in the parasite folate cycle, little information is available about this enzyme, and its crystallographic structure is unknown yet.
Tanos C C, França +3 more
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Cytosolic Plasmodium falciparum serine hydroxymethyltransferase (pfSHMT) is a potential target for antimalarial chemotherapy. Contrasting with the other enzymes involved in the parasite folate cycle, little information is available about this enzyme, and its crystallographic structure is unknown yet.
Tanos C C, França +3 more
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Journal of Fermentation and Bioengineering, 1989
Abstract Fermentative production of l -serine from glycine by Corynebacterium glycinophilum AJ-3413, an auxotrophic mutant of Leu and Met with increased productivity of l -serine using a one liter jar fermentor was carried out and the properties of serine hydroxymethyltransferase (SHMT), a key enzyme in l -serine synthesis, of the parental ...
Koji Kubota, Kenzo Yokozeki
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Abstract Fermentative production of l -serine from glycine by Corynebacterium glycinophilum AJ-3413, an auxotrophic mutant of Leu and Met with increased productivity of l -serine using a one liter jar fermentor was carried out and the properties of serine hydroxymethyltransferase (SHMT), a key enzyme in l -serine synthesis, of the parental ...
Koji Kubota, Kenzo Yokozeki
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The FEBS Journal
Serine hydroxymethyltransferase (SHMT) is a critical enzyme in the one‐carbon (1C) metabolism pathway catalyzing the reversible conversion of L‐Ser into Gly and concurrent transfer of 1C unit to tetrahydrofolate (THF) to give 5,10‐methylene‐THF (5,10‐MTHF), which is used in the downstream syntheses of biomolecules critical for cell
Victoria N. Drago +3 more
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Serine hydroxymethyltransferase (SHMT) is a critical enzyme in the one‐carbon (1C) metabolism pathway catalyzing the reversible conversion of L‐Ser into Gly and concurrent transfer of 1C unit to tetrahydrofolate (THF) to give 5,10‐methylene‐THF (5,10‐MTHF), which is used in the downstream syntheses of biomolecules critical for cell
Victoria N. Drago +3 more
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Planta, 1993
The cell-specific distribution of the four subunit proteins (P, L, T and H) of glycine decarboxylase (GDC) and of serine hydroxymethyltransferase (SHMT) has been studied in the leaves of C3-C4 intermediate and C4 species of three genera (Flaveria, Moricandia and Panicum) using immunogold localization.
C.L. Morgan, S.R. Turner, S. Rawsthorne
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The cell-specific distribution of the four subunit proteins (P, L, T and H) of glycine decarboxylase (GDC) and of serine hydroxymethyltransferase (SHMT) has been studied in the leaves of C3-C4 intermediate and C4 species of three genera (Flaveria, Moricandia and Panicum) using immunogold localization.
C.L. Morgan, S.R. Turner, S. Rawsthorne
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Plant physiology, 1998
In C3 plants large amounts of photorespiratory glycine (Gly) are converted to serine by the tetrahydrofolate (THF)-dependent activities of the Gly decarboxylase complex (GDC) and serine hydroxymethyltransferase (SHMT). Using 13C nuclear magnetic resonance, we monitored the flux of carbon through the GDC/SHMT enzyme system in Arabidopsis thaliana (L ...
V, Prabhu +4 more
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In C3 plants large amounts of photorespiratory glycine (Gly) are converted to serine by the tetrahydrofolate (THF)-dependent activities of the Gly decarboxylase complex (GDC) and serine hydroxymethyltransferase (SHMT). Using 13C nuclear magnetic resonance, we monitored the flux of carbon through the GDC/SHMT enzyme system in Arabidopsis thaliana (L ...
V, Prabhu +4 more
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Glycine synthesis in a Neurospora mutant deficient in serine hydroxymethyltransferase
Plant and Cell Physiology, 1980Edwin A. Cossins +2 more
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Journal of molecular biology, 2000
Serine hydroxymethyltransferase (EC 2.1.2.1), a member of the alpha-class of pyridoxal phosphate enzymes, catalyzes the reversible interconversion of serine and glycine, changing the chemical bonding at the C(alpha)-C(beta) bond of the serine side-chain mediated by the pyridoxal phosphate cofactor.
J N, Scarsdale +4 more
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Serine hydroxymethyltransferase (EC 2.1.2.1), a member of the alpha-class of pyridoxal phosphate enzymes, catalyzes the reversible interconversion of serine and glycine, changing the chemical bonding at the C(alpha)-C(beta) bond of the serine side-chain mediated by the pyridoxal phosphate cofactor.
J N, Scarsdale +4 more
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Mechanism of gating and partial agonist action in the glycine receptor
Cell, 2021Hongtao Zhu +2 more
exaly
Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth
Cell Metabolism, 2022Dzmitry Mukha +2 more
exaly