Results 121 to 130 of about 128,331 (190)

Comprehensive evaluation of lifespan‐extending molecules in C. elegans

Aging Cell, Volume 24, Issue 4, April 2025.
We evaluated 16 of the most frequently reported lifespan‐extending molecules in C. elegans, examining their effects on lifespan with live and UV‐killed OP50. We assessed the compounds' impact on bacterial growth, and their effects on various nematode strains.
Grace B. Phelps, Jonas Morin, Carla Pinto, Lucas Schoenfeldt, Sebastien Guilmot, Alejandro Ocampo, Kevin Perez   +6 more
wiley   +1 more source

A non‐hormonal reversible contraceptive targeting GSK3α, a protein kinase, essential for epididymal sperm maturation

Andrology, EarlyView.
Abstract Background and objectives Epididymal transit renders key competence to mammalian spermatozoa for fertilizing eggs. Generally, the two paralogs of glycogen synthase kinase 3, GSK3α and GSK3β, functionally overlap except in testis and sperm. We showed that GSK3α is essential for epididymal sperm maturation and fertilization.
Mustfa Kabi, Aditi Khamamkar, Kwaku Kyei‐Baffour, Michel Weïwer, Srinivasan Vijayaraghavan, Souvik Dey   +5 more
wiley   +1 more source

In Vitro Assessment of the Potential Effect of Vertical Peri‐Implant Soft Tissue Thickness on Nonsurgical and Surgical Implant Surface Decontamination Methods

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives In vitro analysis of the influence of vertical peri‐implant soft tissue thickness (STT) on nonsurgical and surgical implant surface decontamination efficacy. Material and Methods A total of 360 implants were dipped in indelible color to imitate biofilm contamination, distributed to 30°, 60° or 90° angulated bone defect models and in
Annika Rahner, Peter Eickholz, Jan‐Frederik Gueth, Tuǧba Zahn, Iulia Dahmer, Hari Petsos   +5 more
wiley   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

Are honey bees altering wild plant–bee interactions in reconstructed native habitats? An investigation of summer season effects in row‐crop agroecosystems with prairie strips

Ecological Entomology, EarlyView.
We investigated the compatibility of beekeeping with pollinator conservation in ‘prairie strips’ a conservation practice integrating native prairie habitat into agricultural environments. At prairie strip sites with and without a honey bee apiary, we analysed plant–bee interactions and bumble bee body conditions to determine the effect of apiaries on ...
Kate E. Borchardt, Morgan Moore, Randall Cass, Matthew O'Neal, Amy L. Toth   +4 more
wiley   +1 more source

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

The FEBS Journal, EarlyView.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio, Max Holzknecht, Michèle Petit, Anne Heberle, Yana Rytchenko, Athanasios Seretis, Ciro L. Pierri, Hubert Gstach, Pidder Jansen‐Dürr, Alexander K. H. Weiss   +9 more
wiley   +1 more source

Conversion of pyridoxal to pyridoxamine with NH3 and H2 on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions

The FEBS Journal, EarlyView.
Recent studies show that Ni0 catalyzes amino acid synthesis from 2‐oxoacids via reductive amination. We show that the cofactor pyridoxal is reductively aminated to pyridoxamine, the NH2‐transferring intermediate of transaminations, with NH3 (~ 5 mm) and H2 (5 bar) on Ni0 catalysts within hours in water under serpentinizing hydrothermal vent conditions (
Manon Laura Schlikker, Max Brabender, Loraine Schwander, Carolina Garcia Garcia, Maximillian Burmeister, Sabine Metzger, Joseph Moran, William F. Martin   +7 more
wiley   +1 more source

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

The FEBS Journal, Volume 292, Issue 8, Page 2017-2050, April 2025.
SUCNR1, activated by succinate, is a Gi‐ and Gq‐coupled receptor present at the plasma membrane and in endosomes. There are conflicting reports about the pro‐/anti‐inflammatory effects of the succinate‐SUCNR1 signaling axis, and these are likely due to localization‐dependent signaling.
Aenne‐Dorothea Liebing, Philipp Rabe, Petra Krumbholz, Christian Zieschang, Franziska Bischof, Angela Schulz, Susan Billig, Claudia Birkemeyer, Thanigaimalai Pillaiyar, Mikel Garcia‐Marcos, Robert Kraft, Claudia Stäubert   +11 more
wiley   +1 more source

The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25

The FEBS Journal, EarlyView.
Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found that the small GTPase Rab25 promoted the expression of ADAMTS5 in ovarian cancer cells through the activation of the NF‐κB signalling pathway.
Shengnan Yuan, Rachele Bacchetti, Jamie Adams, Doretta Cuffaro, Armando Rossello, Elisa Nuti, Salvatore Santamaria, Elena Rainero   +7 more
wiley   +1 more source

DmdA‐independent lag phase shortening in Phaeobacter inhibens bacteria under stress conditions

The FEBS Journal, EarlyView.
The lag phase is crucial for resuming bacterial growth and can be shortened by fueling the methionine cycle with methyl groups from DMSP or other methylated compounds. While DmdA is the primary DMSP demethylase in Phaeobacter inhibens, stress activates additional enzymes like Bmt. This enzymatic flexibility allows bacteria to exit the lag phase rapidly,
Delia A. Narváez‐Barragán, Martin Sperfeld, Einat Segev   +2 more
wiley   +1 more source