Results 141 to 150 of about 128,331 (190)

The Human‐Specific miR‐6762‐5p Is an Activator of RhoA GTPase Enhancing Shigella flexneri Intercellular Spreading

open access: yesMolecular Microbiology, Volume 123, Issue 5, Page 420-432, May 2025.
Proposed model in which human miR‐6762‐5p expression activates RhoA to promote Shigella flexneri dissemination: During the late phase of infection, miR‐6762‐5p is expressed from its host gene TPCN1. This leads to RhoA activation and thus stress fiber formation.
Caroline Reisacher   +6 more
wiley   +1 more source

UV PROTECTIVE ACTIVITY OF GLYCINE MAX SEEDS

open access: yesIndian Research Journal of Pharmacy and Science, 2017
Ashok Kumar   +3 more
openaire   +1 more source

Genome‐Wide Analysis of DtxR and HrrA Regulons Reveals Novel Targets and a High Level of Interconnectivity Between Iron and Heme Regulatory Networks in Corynebacterium glutamicum

open access: yesMolecular Microbiology, EarlyView.
Iron is essential for life, yet excessive levels can quickly lead to cellular damage via oxidative stress, underscoring the need for global regulators of iron and heme homeostasis. In this study, we present a genome‐wide analysis of the binding patterns of DtxR and HrrA in Corynebacterium glutamicum.
Aileen Krüger   +2 more
wiley   +1 more source

Sex Specific Effects of Environmental Toxin‐Derived Alpha Synuclein on Enteric Neuronal‐Epithelial Interactions

open access: yesNeurogastroenterology &Motility, EarlyView.
Sex‐specific alterations in intestinal neuronal‐epithelial interactions between calcitonin gene related peptide (CGRP) and goblet cells secondary to elevated enteric alpha synuclein (aSyn) potentially contribute to gastrointestinal dysfunction in Parkinson's Disease (PD). ABSTRACT Background Parkinson's Disease (PD) is a neurodegenerative disorder with
Hayley N. Templeton   +5 more
wiley   +1 more source

Changing Gastrointestinal Transit Time Alters Microbiome Composition and Bile Acid Metabolism: A Cross‐Over Study in Healthy Volunteers

open access: yesNeurogastroenterology &Motility, EarlyView.
Alterations in whole gut transit time (WGTT) significantly impact microbiome composition and bile acid metabolism. Using senna and loperamide, we show that WGTT changes influence bacterial diversity, bile acid profiles, and fibroblast growth factor 19, with effects reversing after 16 days—highlighting the dynamic gut‐microbiome‐bile acid interplay ...
Evette B. M. Hillman   +11 more
wiley   +1 more source

Evolutionary‐conserved RLF, a cytochrome b5‐like heme‐binding protein, regulates organ development in Marchantia polymorpha

open access: yesNew Phytologist, EarlyView.
Summary In Arabidopsis thaliana, REDUCED LATERAL ROOT FORMATION (RLF), a cytochrome b5‐like heme‐binding domain (Cytb5‐HBD) protein, is necessary for proper lateral root (LR) formation. Whereas the other Cytb5‐HBD proteins in A. thaliana regulate different metabolic reactions, RLF is unique as it specifically regulates organ development.
Kentaro P. Iwata   +8 more
wiley   +1 more source

Wild Cicer species exhibit superior leaf photosynthetic phosphorus‐ and water‐use efficiencies compared with cultivated chickpea under low‐phosphorus conditions

open access: yesNew Phytologist, EarlyView.
Summary Domesticated chickpea cultivars exhibit limited genetic diversity. This study evaluated the effects of chickpea domestication on phosphorus (P)‐use efficiency (PUE) under low‐P conditions, using a diverse Cicer collection, including wild species. Two wild Cicer species – 54 C. reticulatum accessions and 15 C. echinospermum accessions, and seven
Jiayin Pang   +8 more
wiley   +1 more source

PlantLncBoost: key features for plant lncRNA identification and significant improvement in accuracy and generalization

open access: yesNew Phytologist, EarlyView.
Summary Long noncoding RNAs (lncRNAs) are critical regulators of numerous biological processes in plants. Nevertheless, their identification is challenging due to the low sequence conservation across various species. Existing computational methods for lncRNA identification often face difficulties in generalizing across diverse plant species ...
Xue‐Chan Tian   +5 more
wiley   +1 more source

Receptor‐like kinases BIR1 and BIR3 modulate antiviral resistance by different mechanisms

open access: yesNew Phytologist, EarlyView.
Summary BRASSINOSTEROID INSENSITIVE1‐ASSOCIATED RECEPTOR KINASE 1 (BAK1)‐INTERACTING RECEPTOR‐LIKE KINASE (BIR) proteins are negative regulators of cell death and defense against microbes in Arabidopsis thaliana. Here, we demonstrate that the members of the BIR family function as negative regulators of antiviral resistance in Arabidopsis.
Carmen Robinson   +8 more
wiley   +1 more source

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