Results 71 to 80 of about 90,043 (297)
Angewandte Chemie, EarlyView.To monitor small molecule‐induced changes in protein polyubiquitination in an unbiased manner, we employ enrichment through tandem ubiquitin binding entities coupled to LC‐MS/MS analysis (TUBE‐MS). By applying the workflow to PROTAC, p97‐ and deubiquitinase‐inhibitor treatment of cells, we demonstrate its broad applicability and reveal the induction of
Siska Führer +6 more
wiley +2 more sources
Molecular Analysis of Lipoxygenases Associated with Nodule Development in Soybean
Molecular Plant-Microbe Interactions, 2008 We utilized transcriptional profiling to identify genes associated with nodule development in soybean. Many of the candidate genes were predicted to be involved in processes such as defense, metabolism, transcriptional regulation, oxidation, or iron ...
Satomi Hayashi +2 more
doaj +1 more source
Advanced Science, EarlyView.PRO‐LDM is a modular latent diffusion framework that learns hierarchical biological representations to enable efficient and high‐fidelity protein design. PRO‐LDM can design species that resemble natural sequences with enhanced diversity or optimize protein functions.
Sitao Zhang +15 more
wiley +1 more source
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Advanced Science, EarlyView.Breast cancer cells undergo metabolic and transcriptomic reprogramming to support aberrant cell proliferation. Their mitochondria rely on the transfer of phosphatidylcholine from the endoplasmic reticulum to their membranes by STARD7, a candidate upregulated in breast cancer, to be functional.
Ewelina Dondajewska +18 more
wiley +1 more source
Structural Variations Associated with Adaptation and Coat Color in Qinghai‐Tibetan Plateau Cattle
Advanced Science, EarlyView.This study reveals the landscape of structural variants in Qinghai‐Tibetan Plateau cattle through long‐read sequencing. Discoveries include metabolic and oxygen‐regulation gene variants, along with a 2‐Mb KIT‐containing inversion and translocations responsible for cattle gray coat. These findings highlight the significant role of structural variants in
Xiaoting Xia +39 more
wiley +1 more source
Acta Scientiarum: Agronomy, 2008 Foram analisados os efeitos da interação entre genótipos e ambientes (GxE) sobre a adaptabilidade e a estabilidade do rendimento de 9 linhagens elite de soja (Glycine Max (L.) Merrill) e uma testemunha (IAS 5), observadas em 11 locais em 2000/01 e 2001 ...
Dorival Vicente +2 more
doaj +1 more source
RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics
Advanced Science, EarlyView.RAB5A‐mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellular organization relying on nanoscale integrin clustering, and the formation of a stiff and collective actin cable; and c) softening of the spheroid core ...
Grégoire Lemahieu +19 more
wiley +1 more source
Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis
Advanced Science, EarlyView.Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves +17 more
wiley +1 more source
Ciência e Agrotecnologia, 2008 Objetivou-se no presente trabalho, estudar os efeitos da combinação entre teores de água do solo e cargas aplicadas pela roda compactadora da semeadora-adubadora sobre a emergência de plântulas de soja, em sistema plantio direto.
Alcir José Modolo +3 more
doaj +1 more source
GmSop20 Functions as a Key Coordinator of the Oil‐To‐Protein Ratio in Soybean Seeds
Advanced Science, EarlyView.This study investigates the seed oil‐to‐protein ratio as a comprehensive quality metric and identifies GmSop20 as a crucial regulatory gene through forward genetics methodologies. By integrating GmSop20 with superior haplotypes and using gene editing/overexpression, new strategies are provided for precisely tuning the seed oil‐to‐protein ratio, thereby
Haowei Zheng +17 more
wiley +1 more source