Results 161 to 170 of about 359,192 (401)
A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands
ChemMedChem, EarlyView.A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova +15 more
wiley +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Photosynthesis and Productivity of Soybean (Glycine max (L.) Merr.]
, 2010 The peculiarities of leaf carbon dioxide gas exchange in soybean genotypes grown in field over a largearea and contrasting in duration of vegetation, photosynthetie traits and productivity were studied.Varietal differences in the daily and ontogenetic changes in photosynthesis and photorespiration wereidentified.
Jalal A. Aliyev, Rufat S. Mirzoyev
openaire +1 more source
Metal‐Directed Self‐Assembly in a Beta‐Sheet Miniprotein Scaffold
European Journal of Inorganic Chemistry, EarlyView.A rationally engineered miniprotein, V14C, which is based on the beta β‐sheet Foldon domain, self‐assembles via a metal‐binding site to form well‐defined oligomers in the presence of Zn2+, Hg2+, and Cd2+. This modular design expands the toolbox for creating custom metalloproteins, enabling studies of metal–protein interactions for biochemical functions
Chandan Muni Reddy +3 more
wiley +1 more source
Ribosomal RNA operon copy number: A trait‐informed framework to close the microbial cultivation gap
iMetaOmics, EarlyView.The vast majority of microbes remain uncultured, constraining functional validation and limiting microbiome‐based applications. We show that ribosomal RNA operon (rrn) copy number—a stable, phylogenetically conserved genomic trait—is strongly correlated with cultivation outcomes across ecosystems.
Yuxiao Huang +8 more
wiley +1 more source
Genetic analysis of yield and yield components in soybean [Glycine max(L.) Merrill]
, 2014 T. J. Bhor +2 more
openalex +1 more source
Selenium biofortification: integrating one health and sustainability
Journal of the Science of Food and Agriculture, EarlyView.Abstract Selenium (Se) biofortification in crops has emerged as a promising strategy to address global Se deficiencies and enhance both agricultural productivity and human health. Increasing the Se content of crops through biofortification improves their resilience to abiotic and biotic stresses and boosts their nutritional value.
Silvia Estarriaga‐Navarro +3 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
Laser &Photonics Reviews, EarlyView.A high‐speed, multi‐color light‐sheet microscope, named quad‐SPIM, enables rapid three dimensional (3D) imaging of large cleared human brain samples with simultaneous four‐channel acquisition. This custom‐built system achieves subcellular resolution across centimeter‐scale volumes, maintaining high image quality.
Laura Perego +11 more
wiley +1 more source