Results 101 to 110 of about 1,587,740 (262)
Frontiers in Molecular Neuroscience, 2018 Glycine receptors (GlyRs) are important mediators of fast inhibitory neurotransmission in the mammalian central nervous system. Their function is controlled by multiple cellular mechanisms, including intracellular regulatory processes. Modulation of GlyR
Ulrike Breitinger +6 more
doaj +1 more source
The persistence and genetic support of genes encoding antibiotic resistance in oral bacteria. [PDF]
, 2005 Antibiotic-resistant bacteria present a serious public health threat and studies investigating the prevalence of antibiotic-resistant bacteria and the genes encoding for antibiotic resistance (GEAR) are essential.
Lancaster, Holli Louise, Lancaster, H.L.
core
New synthetic bile acid analogue agonists of FXR and TGR5 receptors: Analytical methodologies for the study of their physico-chemical properties, pharmacokinetic activity and metabolism. [PDF]
, 2013 This thesis reports an integrated analytical approach for the study of physicochemical and biological properties of new synthetic bile acid (BA) analogues agonists of FXR and TGR5 receptors.
Colliva, Carolina <1981>
core +1 more source
3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress
Advanced Materials Technologies, EarlyView.Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi +4 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2018 Mutations in GlyR α1 or β subunit genes in humans and rodents lead to severe startle disease characterized by rigidity, massive stiffness and excessive startle responses upon unexpected tactile or acoustic stimuli.
Natascha Schaefer +10 more
doaj +1 more source
Fabrication and use of D-serine biosensors for characterising D-serine signalling in rat brain [PDF]
D-serine is a co-agonist at NMDA receptors in the brain but the study of this amino acid is restricted by current techniques. I have designed highly sensitive D-serine biosensors that permit accurate real-time recordings of D-serine in the brain in a ...
Bibi, Shakila
core
Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo [PDF]
, 2013 N-methyl-d-aspartate receptor (NMDAR) activation can initiate changes in synaptic strength, evident as long-term potentiation (LTP), and is a key molecular correlate of memory formation.
Kerry L. Spear +15 more
core +1 more source
Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2018 Inhibitory glycine receptors (GlyRs) are pentameric ligand-gated anion channels with major roles in startle disease/hyperekplexia (GlyR α1), cortical neuronal migration/autism spectrum disorder (GlyR α2), and inflammatory pain sensitization/rhythmic ...
Sophie Leacock +10 more
doaj +1 more source
Probing the Pharmacophore of Ginkgolides as Glycine Receptor Antagonists
, 2016 Ginkgolides are antagonists of the inhibitory ligand-gated ion channels for the neurotransmitters glycine and γ-aminobutyric acid (GABA). In this study the ginkgolide structure was modified in order to investigate the minimum structural requirements for ...
Kristian Strømgaard (412489) +9 more
core +1 more source