Results 81 to 90 of about 258,627 (303)
Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors
, 2007 Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D. +3 more
core
Mechanism of glycine protection in hypoxic injury: Analogies with glycine receptor
, 1992 Mechanism of glycine protection in hypoxic injury: Analogies with glycine receptor. Addition of glycine to the recirculating perfusate of isolated perfused rat kidneys protects against hypoxic injury to the medullary thick ascending limb and slows ...
Heyman, Samuel +3 more
core +1 more source
Advanced Materials, EarlyView.Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa +6 more
wiley +1 more source
The GlyR Extracellular β8–β9 Loop – A Functional Determinant of Agonist Potency
Frontiers in Molecular Neuroscience, 2017 Ligand-binding of Cys-loop receptors results in rearrangements of extracellular loop structures which are further translated into the tilting of membrane spanning helices, and finally opening of the ion channels.
Dieter Janzen +4 more
doaj +1 more source
Recombinant glycine receptors: stoichiometry and kinetics
, 2009 Glycine receptors (GlyR) are anion-permeable channels that belong to the pentameric ligand-gated ion channel family. Different GlyR subtypes are known. The main synaptic form is thought to be α1β heteropentamers which mediate fast synaptic inhibition in ...
Krashia, P.
core
Dexime: A Selectively Enzyme‐Degradable Hydrogel for Protein Therapeutic Release
Advanced Materials, EarlyView.A dextrin‐oxime hydrogel (dexime) is produced using ketone or aldehyde modified dextrin and tetra‐oxyamine modified poly(ethylene glycol). The rheological and mechanical properties of dexime are tunable. Dexime is injectable, cytocompatible, hydrolytically stable, and selectively degradable by α‐amylase.
Quinton E. A. Sirianni +5 more
wiley +1 more source
, 2004 The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Burzomato, V. +4 more
core
Ratiometric Mycotoxin Detection in Living Plants With Dual‐Emissive Nanosensors
Advanced Materials, EarlyView.A minimally invasive microneedle patch integrates carbon dot‐embedded metal–organic frameworks as nanosensors to detect a key fungal toxin in living plants. The nanosensor produces a ratiometric fluorescence signal that enables early, non‐destructive diagnosis of fungal infection before visible symptoms, offering a new biomaterials‐based strategy for ...
Yuliang Li +9 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2014 In the developing cerebral cortex, the marginal zone (MZ), consisting of early-generated neurons such as Cajal-Retzius cells, plays an important role in cell migration and lamination.
Taizhe eQian +10 more
doaj +1 more source
The activation mechanism of alpha 1 homomeric glycine receptors
, 2004 The glycine receptor mediates fast synaptic inhibition in the spinal cord and brainstem. Its activation mechanism is not known, despite the physiological importance of this receptor and the fact that it can serve as a prototype for other homopentameric ...
Sivilotti, LG +3 more
core