Results 251 to 260 of about 258,627 (303)
Advanced NanoBiomed Research, EarlyView.Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo +7 more
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Pharmacology & Therapeutics, 1997 The inhibitory glycine receptor (GlyR) is a member of the ligand-gated ion channel receptor superfamily. The GlyR comprises a pentameric complex that forms a chloride-selective transmembrane channel, which is predominantly expressed in the spinal cord and brain stem. We review the pharmacological and physiological properties of the GlyR and relate this
Joseph W Lynch +2 more
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General Pharmacology: The Vascular System, 1978
Abstract 1. Recent studies aimed at elucidating synaptic glycine-receptors have been reviewed. 2. Biochemical and iontophoretic findings have revealed that such receptors exist in several regions of the vertebrate CNS. 3. Subcellular studies with labelled strychnine and glycine have revealed that strychnine does not interact directly with glycine ...
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Abstract 1. Recent studies aimed at elucidating synaptic glycine-receptors have been reviewed. 2. Biochemical and iontophoretic findings have revealed that such receptors exist in several regions of the vertebrate CNS. 3. Subcellular studies with labelled strychnine and glycine have revealed that strychnine does not interact directly with glycine ...
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Modulators of the Inhibitory Glycine Receptor
ACS Chemical Neuroscience, 2020The inhibitory glycine receptor is a member of the Cys-loop superfamily of ligand-gated ion channels. It is the principal mediator of rapid synaptic inhibition in the spinal cord and brainstem and plays an important role in the modulation of higher brain functions including vision, hearing, and pain signaling. Glycine receptor function is controlled by
Ulrike Breitinger, Hans-Georg Breitinger
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The inhibitory neuronal glycine receptor
BioEssays, 1994AbstractGlycine is a major inhibitory neurotransmitter in the spinal cord and in the brain stem, where it acts by activating a chloride conductance. The postsynaptic glycine receptor has been purified and contains two transmembrane subunits of 48 kDa (α) and 58 kDa (β), and a peripheral membrane protein of 93 kDa.
C, Béchade, C, Sur, A, Triller
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1985
In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
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In the vertebrate CNS, many different compounds including acetylcholine, catecholamines, peptides, and amino acids have been identified as bona fide or candidate neurotransmitter substances. Amongst these the amino acids glycine and GABA have been particularly well characterized.
H. Betz +4 more
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Functional reconstitution of the glycine receptor
Biochemistry, 1989The functional reconstitution of the chloride channel coupled glycine receptor is described. Glycine receptors were purified from the cholate extract of rat spinal cord membranes by affinity chromatography and incorporated into phospholipid vesicles by the addition of phosphatidylcholine and removal of detergent by gel filtration.
M, García-Calvo +5 more
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Biology of the Postsynaptic Glycine Receptor
1997Glycine is one of the major inhibitory neurotransmitters, and upon binding to its receptor it activates chloride conductances. Receptors are accumulated immediately opposite release sites, at the postsynaptic differentiations, where they form functional microdomains.
C, Vannier, A, Triller
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In vitro interaction of the glycine receptor with the leptin receptor
Physiology & Behavior, 2002The coordination and regulation of electrical signals across excitable cells is a complex, dynamic phenomenon requiring, in part, the interaction of ion channels with cellular constituents. The intracellular loops or domains of many ion channel subunits have been shown to specifically bind other cellular components that act in receptor targeting ...
John F, Leite +3 more
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Journal of Neurophysiology, 2005
Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
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Glycinergic and GABAergic inhibition are juxtaposed at one retinal synaptic layer yet likely perform different functions. These functions have usually been evaluated using receptor antagonists. In examining retinal glycine receptors, we were surprised to find that commonly used concentrations of GABA antagonists blocked significant fractions of the ...
Peiyuan, Wang, Malcolm M, Slaughter
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