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Gathering Glycine Receptors at Synapses
Science, 1998Neurons send their signals to the next neuron by shooting neurotransmitters across the intracellular gulf to a cluster of receptors on the downstream neuron. As discussed by Froehner in his Perspective, these receptors are held in place by so-called scaffolding proteins on the inside of the cell. A new example of such proteins is reported on page [1321]
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Hijacking of GABAA Receptors by Mutant Glycine Receptors
Trends in Molecular Medicine, 2019Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al.
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Regulation of Excitation by Glycine Receptors
2007Our knowledge of glycine receptor (GlyR) regulation of excitation has advanced significantly in recent years. GlyRs are widespread in the CNS, are heterogeneous, and undergo developmental changes. Activation of GlyRs of immature neurons induces outflow of Cl( - ), membrane depolarization, neuronal excitation, calcium influx, and transmitter release, in
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Science Signaling, 2003
Semiconductor quantum dots (QDs) have recently emerged as probes with the potential to revolutionize fluorescence imaging. Dahan et al. have now detected single QD-tagged glycine receptors in living cultured spinal neurons.
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Semiconductor quantum dots (QDs) have recently emerged as probes with the potential to revolutionize fluorescence imaging. Dahan et al. have now detected single QD-tagged glycine receptors in living cultured spinal neurons.
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