Results 71 to 80 of about 175,730 (291)
Principles of agonist recognition in Cys-loop receptors
Frontiers in Physiology, 2014 Cys-loop receptors are ligand-gated ion channels that are activated by a structurally diverse array of neurotransmitters, including acetylcholine, serotonin, glycine and GABA.
Timothy eLynagh, Stephan Alexander Pless
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source
Recombinant glycine receptors: stoichiometry and kinetics
, 2009 Glycine receptors (GlyR) are anion-permeable channels that belong to the pentameric ligand-gated ion channel family. Different GlyR subtypes are known. The main synaptic form is thought to be α1β heteropentamers which mediate fast synaptic inhibition in ...
Krashia, P.
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Nature Communications, 2016 Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic ...
Jessica T. Y. Yue +8 more
doaj +1 more source
Natural Biomaterials for Osteochondral Repair: From Source to Strategy
Advanced Healthcare Materials, EarlyView.Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu +5 more
wiley +1 more source
An electrophysiological study of the interaction between fenamate NSAIDs and the GABA(_A) receptor [PDF]
, 1999 The effects of certain NSAIDs were determined on agonist-evoked responses recorded from rat neurones maintained in vitro using electrophysiological techniques. Initially, the rat isolated vagus and optic nerves were employed. Alphaxalone, pentobarbitone,
Patten, Debra
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Advanced Healthcare Materials, EarlyView.Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He +9 more
wiley +1 more source
Single channel study of the spasmodic mutation α1A52S in recombinant rat glycine receptors
, 2007 Inherited defects in glycine receptors lead to hyperekplexia, or startle disease. A mutant mouse, spasmodic, that has a startle phenotype, has a point mutation (A52S) in the glycine receptor α1 subunit.
Colquhoun, D. +3 more
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Advanced Healthcare Materials, EarlyView.Gellan gum fluid gel (FG) enables controlled ocular delivery of mesenchymal stromal cell (MSC)‐derived extracellular vesicles (EV). Its shear‐thinning, solid‐liquid‐solid rheology ensures prolonged ocular retention. Sustained MSC‐EV release (∼18% in 6 hrs) supports effective EV ocular delivery.
Seyedmohammad Moosavizadeh +7 more
wiley +1 more source
, 2004 The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Burzomato, V. +4 more
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