Results 111 to 120 of about 260,438 (309)

Toward 3D‐Bioprinted Models of the Liver to Boost Drug Development

Macromolecular Bioscience, Volume 22, Issue 12, December 2022., 2022
During preclinical studies, bidimensional in vitro models and animal models are synergically exploited to forecast safety and efficacy. 3D‐bioprinting is exploited to produce complex in vitro models, able to mimic physiological and pathological conditions, thus aiming to overcome the conventional paradigm.
Giuseppe Guagliano, Cristina Volpini, Francesco Briatico‐Vangosa, Antonia Icaro Cornaglia, Livia Visai, Paola Petrini   +5 more
wiley   +1 more source

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Molecular cloning and expression of glycogen synthase kinase‐3/factor A.

EMBO Journal, 1990
Glycogen synthase kinase‐3 (GSK‐3) is a protein‐serine kinase implicated in the hormonal control of several regulatory proteins including glycogen synthase and the transcription factor c‐jun.
J. Woodgett
semanticscholar   +1 more source

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Antioxidants and Antidiabetic Potential of Polyphenolic Fractions and Crude Extracts of Rhus coriaria L. Fruit, Punica granatum L. Peel, and Terminalia catappa L. Leaves: In Vitro and In Vivo Evaluation

Chemistry &Biodiversity, EarlyView.
This graphical abstract represents the extraction, characterization, and biological evaluation of bioactive compounds derived from specific plant sources. The top section illustrates Rhus coriaria (sumac) fruit, Punica granatum (pomegranate) peel and Terminalia catappa (Indian almond) leaves', which are known for their rich phytochemical composition ...
Mudassir Nazir, Muhammad Abdul Haq, Syed Arsalan Ali, Syed Muhammad Ghufran Saeed, Muhammad Ali Ajmal, Muhammad Nisar, Taseer Ahmed Khan, Alexandros Tsoupras, Shahina Naz   +8 more
wiley   +1 more source

Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

New England Journal of Medicine, 1990
To examine the extent to which the defect in insulin action in subjects with non-insulin-dependent diabetes mellitus (NIDDM) can be accounted for by impairment of muscle glycogen synthesis, we performed combined hyperglycemic-hyperinsulinemic clamp ...
G. Shulman, D. Rothman, T. Jue, P. Stein, R. DeFronzo, R. Shulman   +5 more
semanticscholar   +1 more source

Lamellarin D Acts as an Inhibitor of Type I Collagen Production

ChemMedChem, EarlyView.
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno, Noriho Sakamoto, Hideki Hayashi, Tsutomu Fukuda, Yoshiko Akiyama, Chiaki Iketani, Ritsuko Murakami, Takatomo Tokito, Takuto Miyamura, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Shinnosuke Takemoto, Takahiro Takazono, Tomoya Nishino, Yuji Ishimatsu, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae   +19 more
wiley   +1 more source

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

β‐Catenin localization in the ctenophore Mnemiopsis leidyi suggests an ancestral role in cell adhesion and nuclear function

Developmental Dynamics, EarlyView.
Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters, Lucas J. Guttieres, Mayline Goëb, Stanley J. Marjenberg, Mark Q. Martindale, Athula H. Wikramanayake   +5 more
wiley   +1 more source

Enzymes concerned in the synthesis of glycogen from glucose in the brown adipose tissue [PDF]

, 1951
N. H. Creasey, C. H. GRAY
openalex   +1 more source