Deficiency of glycogen synthase promotes lipid accumulation through ChREBP and AKT-mTOR1-SREBP1 axis activation in mice [PDF]
Journal of Lipid ResearchMetabolic dysfunction-associated steatotic liver disease (MASLD) has become highly prevalent worldwide, largely as a consequence of the global obesity epidemic.
Liangkui Li +3 more
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Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease [PDF]
Clinical and Translational MedicinePompe disease (PD) is a progressive myopathy caused by the aberrant accumulation of glycogen in skeletal and cardiac muscle resulting from the deficiency of the enzyme acid alpha‐glucosidase (GAA).
Lan Weiss +18 more
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Intermittent Fasting Modulates the Glycogen Level in Zebrafish (Danio rerio) and their Next Generation [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Zebrafish (Danio rerio) has become the best model organism to study the evolutionary biological process and human developmental studies.
ShanmugaSundaram Tamilarasan +2 more
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Glycogen synthase GYS1 overactivation contributes to glycogen insolubility and malto-oligoglucan-associated neurodegenerative disease [PDF]
The EMBO JournalPolyglucosans are glycogen molecules with overlong chains, which are hyperphosphorylated in the neurodegenerative Lafora disease (LD). Brain polyglucosan bodies (PBs) cause fatal neurodegenerative diseases including Lafora disease and adult polyglucosan ...
Silvia Nitschke +12 more
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Gsk-3$ \beta $ aggravates depression symptoms in a chronic stress mouse model [PDF]
Journal of Integrative Neuroscience, 2018 Depression caused by genetic and environmental factors is acomplicated disease. Here, it is demonstrated that glycogen synthase kinase-3$\beta$ is highly expressed and phosphorylated in the brain of a chronic stress mouse. Inhibition of glycogen synthase
Hong Peng, Hong-bin Wang, Ling Wang, Bing Zhou, Xiao-yong Li, Jian Tan
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Biology, 2021 Glycogen synthase kinase-3 beta is a ubiquitously and constitutively expressed molecule with pleiotropic function. It acts as a protooncogene in the development of several solid tumors including pancreatic cancer through its involvement in various ...
Robin Park +3 more
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Regulatory Functions of Nilaparvata lugens GSK-3 in Energy and Chitin Metabolism
Frontiers in Physiology, 2020 Glucose metabolism is a biologically important metabolic process. Glycogen synthase kinase (GSK-3) is a key enzyme located in the middle of the sugar metabolism pathway that can regulate the energy metabolism process in the body through insulin signaling.
Yan-Juan Ding +7 more
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Glycogen synthase isoforms in Synechocystis sp. PCC6803: identification of different roles to produce glycogen by targeted mutagenesis. [PDF]
PLoS ONE, 2014 Synechocystis sp. PCC6803 belongs to cyanobacteria which carry out photosynthesis and has recently become of interest due to the evolutionary link between bacteria and plant species.
Sang-Ho Yoo +4 more
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Mechanism of glycogen synthase inactivation and interaction with glycogenin
Nature Communications, 2022 Glycogen is a major energy reserve in eukaryotes and is synthesised in part by glycogenin (GN) and glycogen synthase (GS). Here, authors describe the structural basis of GS regulation, specifically the mechanism of inactivation by phosphorylation.
Laura Marr +13 more
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Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. [PDF]
PLoS ONE, 2010 When oxygen becomes limiting, cells reduce mitochondrial respiration and increase ATP production through anaerobic fermentation of glucose. The Hypoxia Inducible Factors (HIFs) play a key role in this metabolic shift by regulating the transcription of ...
Nuria Pescador +12 more
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