Results 21 to 30 of about 82,991 (164)

Islet Transplantation under the Kidney Capsule Corrects the Defects in Glycogen Metabolism in Both Liver and Muscle of Streptozocin-Diabetic Rats

Cell Transplantation, 2002
Insulin-deficient rats are characterized by multiple defects in the pathway of glycogen synthesis and breakdown in both liver and skeletal muscle. The aim of this study was to clarify whether islet transplantation under the kidney capsule, which is ...
Margherita Matarazzo, Maria Grazia Giardina, Vincenzo Guardasole, Alberto M. Davalli, Edward S. Horton, Gordon C. Weir, Luigi Saccà, Raffaele Napoli   +7 more
doaj   +1 more source

Hexokinase 2, glycogen synthase and phosphorylase play a key role in muscle glycogen supercompensation. [PDF]

PLoS ONE, 2012
BackgroundGlycogen-depleting exercise can lead to supercompensation of muscle glycogen stores, but the biochemical mechanisms of this phenomenon are still not completely understood.MethodsUsing chronic low-frequency stimulation (CLFS) as an exercise ...
José M Irimia, Jordi Rovira, Jakob N Nielsen, Mario Guerrero, Jørgen F P Wojtaszewski, Roser Cussó   +5 more
doaj   +1 more source

Antisense Oligonucleotide-mediated Suppression of Muscle Glycogen Synthase 1 Synthesis as an Approach for Substrate Reduction Therapy of Pompe Disease

Molecular Therapy: Nucleic Acids, 2014
Pompe disease is an autosomal recessive disorder caused by a deficiency of acid α-glucosidase (GAA; EC 3.2.1.20) and the resultant progressive lysosomal accumulation of glycogen in skeletal and cardiac muscles.
Nicholas P Clayton, Carol A Nelson, Timothy Weeden, Kristin M Taylor, Rodney J Moreland, Ronald K Scheule, Lucy Phillips, Andrew J Leger, Seng H Cheng, Bruce M Wentworth   +9 more
doaj   +1 more source

Glycogen storage disease type 0 due to a novel frameshift mutation in glycogen synthase 2 (GYS2) gene in a child presenting with fasting hypoglycemia and postprandial hyperglycemia

The Turkish Journal of Pediatrics, 2018
Glycogen storage disease type 0 (GSD0) has been considered a rare disorder, it is characterized with ketotic hypoglycemia after prolonged fasting and postprandial hyperglycemia.
Bülent Hacıhamdioğlu, Gamze Özgürhan, Bahar Çaran, Evrim Meydan-Aksanlı, Ece Keskin   +4 more
doaj   +1 more source

Vitamin C deficiency induces hypoglycemia and cognitive disorder through S-nitrosylation-mediated activation of glycogen synthase kinase 3β

Redox Biology, 2022
Vitamin C (VC, l-ascorbic acid) is an essential nutrient that plays a key role in metabolism and functions as a potent antioxidant in regulating the S-nitrosylation and denitrosylation of target proteins. The precise function of VC deprivation in glucose
Yingying Shu, Chaochun Zou, Yuqing Cai, Qiangqiang He, Xiaowei Wu, Haibin Zhu, Meiyu Qv, Yunqi Chao, Chengyun Xu, Lanfang Tang, Ximei Wu   +10 more
doaj   +1 more source

Molecular basis of impaired glycogen metabolism during ischemic stroke and hypoxia. [PDF]

PLoS ONE, 2014
BACKGROUND: Ischemic stroke is the combinatorial effect of many pathological processes including the loss of energy supplies, excessive intracellular calcium accumulation, oxidative stress, and inflammatory responses.
Mohammed Iqbal Hossain, Carli Lorraine Roulston, David Ian Stapleton   +2 more
doaj   +1 more source

Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States. [PDF]

PLoS ONE, 2015
Human pluripotent stem cells (hPSCs) represent very promising resources for cell-based regenerative medicine. It is essential to determine the biological implications of some fundamental physiological processes (such as glycogen metabolism) in these stem
Richard J Chen, Guofeng Zhang, Susan H Garfield, Yi-Jun Shi, Kevin G Chen, Pamela G Robey, Richard D Leapman   +6 more
doaj   +1 more source

Activated Protein C Induces Endoplasmic Reticulum Stress and Attenuates Lipopolysaccharide-Induced Apoptosis Mediated by Glycogen Synthase Kinase-3β

Mediators of Inflammation, 2012
This study investigated the relationship between antiapoptotic activities induced by activated protein C and endoplasmic reticulum stress. In this study, it was observed that activated protein C elicited a rise in glucose-regulated protein 78 and ...
Liang Luo, Tangfeng Lv, Qian Wang, Ting Zhang, Xiaoling Gu, Feng Xu, Yong Song   +6 more
doaj   +1 more source

A whole-body model for glycogen regulation reveals a critical role for substrate cycling in maintaining blood glucose homeostasis.

PLoS Computational Biology, 2011
Timely, and sometimes rapid, metabolic adaptation to changes in food supply is critical for survival as an organism moves from the fasted to the fed state, and vice versa.
Ke Xu, Kevin T Morgan, Abby Todd Gehris, Timothy C Elston, Shawn M Gomez   +4 more
doaj   +1 more source

Glucoregulatory effect of butyrate is associated with elevated circulating VEGF and reduced cardiac lactate in high fructose fed rats

Heliyon, 2023
Background: High fructose diet has been linked with impaired body metabolism and cardiovascular diseases. Sodium butyrate (NaB) was documented to improve glucoregulation and cardiometabolic problems associated with high fructose diet (HFrD) but the ...
Adewumi Oluwafemi Oyabambi, Olubayode Bamidele, Aindero Blessing Boluwatife, Lawrence Dayo Adedayo   +3 more
doaj   +1 more source